Zobrazeno 1 - 10
of 39
pro vyhledávání: '"William J, Faller"'
Autor:
Jaskaren Kohli, Chen Ge, Eleni Fitsiou, Miriam Doepner, Simone M. Brandenburg, William J. Faller, Todd W. Ridky, Marco Demaria
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Cutaneous hyperpigmented lesions, including nevi, are populated by senescent melanocytes. Here the authors provide evidence for a novel strategy based on combining inhibition of the BCL-2 and MCL1 anti-apoptotic pathways that selectively eliminates s
Externí odkaz:
https://doaj.org/article/8202b04d72ce4f228b04c8c3764d037c
Autor:
Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and infla
Externí odkaz:
https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c67
Autor:
Tânia Martins Garcia, Manon van Roest, Jacqueline L.M. Vermeulen, Sander Meisner, Wouter L. Smit, Joana Silva, Pim J. Koelink, Jan Koster, William J. Faller, Manon E. Wildenberg, Ruurd M. van Elburg, Vanesa Muncan, Ingrid B. Renes
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 943-981 (2021)
Background & Aims: The use of antibiotics (ABs) is a common practice during the first months of life. ABs can perturb the intestinal microbiota, indirectly influencing the intestinal epithelial cells (IECs), but can also directly affect IECs independ
Externí odkaz:
https://doaj.org/article/afed24ff78e34bfc84d8b50808a76145
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
All supplemental figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee3a26e547749f005f869f86f6004e
https://doi.org/10.1158/2159-8290.22540555
https://doi.org/10.1158/2159-8290.22540555
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56670615fce027f717d8d9f47081b8
https://doi.org/10.1158/2159-8290.c.6549409
https://doi.org/10.1158/2159-8290.c.6549409
Autor:
Ferhat Alkan, Oscar G Wilkins, Santiago Hernández-Pérez, Sofia Ramalho, Joana Silva, Jernej Ule, William J Faller
Publikováno v:
Alkan, F, Wilkins, O G, Hernández-Pérez, S, Ramalho, S, Silva, J, Ule, J & Faller, W J 2022, ' Identifying ribosome heterogeneity using ribosome profiling ', Nucleic Acids Research, vol. 50, no. 16, pp. e95 . https://doi.org/10.1093/nar/gkac484
Recent studies have revealed multiple mechanisms that can lead to heterogeneity in ribosomal composition. This heterogeneity can lead to preferential translation of specific panels of mRNAs, and is defined in large part by the ribosomal protein (RP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d302d8bf12113a0038b671c3bca954a2
https://kclpure.kcl.ac.uk/en/publications/69391a34-d84b-47e0-9cd8-3163c5f0da0f
https://kclpure.kcl.ac.uk/en/publications/69391a34-d84b-47e0-9cd8-3163c5f0da0f
Publikováno v:
Bioinformatics
Motivation Ribosome Profiling (Ribo-seq) has revolutionized the study of RNA translation by providing information on ribosome positions across all translated RNAs with nucleotide-resolution. Yet several technical limitations restrict the sequencing d
Autor:
Emma Minnee, William J. Faller
Publikováno v:
The FEBS Journal. 288:6635-6651
Protein synthesis is one of the most essential processes in every kingdom of life, and its dysregulation is a known driving force in cancer development. Multiple signaling pathways converge on the translation initiation machinery, and this plays a cr
Autor:
Jan Koster, Pim J. Koelink, Manon van Roest, Sander Meisner, Ingrid B. Renes, William J. Faller, Joana Silva, Wouter L. Smit, Jacqueline L.M. Vermeulen, Manon E. Wildenberg, Vanesa Muncan, Ruurd M. van Elburg, Tânia Martins Garcia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 943-981 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 12(3), 943-981. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 12(3), 943-981. Elsevier Inc.
Background & Aims The use of antibiotics (ABs) is a common practice during the first months of life. ABs can perturb the intestinal microbiota, indirectly influencing the intestinal epithelial cells (IECs), but can also directly affect IECs independe
Autor:
Thom M. Molenaar, Eliza Mari Kwesi-Maliepaard, Joana Silva, Muddassir Malik, William J. Faller, Fred van Leeuwen
Cell size varies between cell types but is tightly regulated by cell-intrinsic and extrinsic mechanisms. Cell-size control is important for cell function and changes in cell size are frequently observed in cancer cells. Here we uncover a non-canonica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c2de764f9b2a2c7988413b9fb683cc
https://doi.org/10.1101/2021.10.31.465891
https://doi.org/10.1101/2021.10.31.465891