Zobrazeno 1 - 10
of 32
pro vyhledávání: '"William J, Egan"'
Autor:
William J. Egan
Publikováno v:
SSRN Electronic Journal.
This analysis sought to determine an upper limit for the S&P 500 price-to-earnings ratio (P/E) under normal market and economic conditions considering interest rates. Data covered the period from Jan 1962 to Jan 2021. Time series were the weekly S&P
Autor:
William J. Egan, Timothy L. Schofield
Publikováno v:
Biologicals. 37:379-386
An understanding of the principles of degradation, as well as the statistical tools for measuring product stability, is essential to management of product quality. Key to this is management of vaccine potency. Vaccine shelf life is best managed throu
Publikováno v:
Drug Discovery Today: Technologies. 1:381-387
Predictive models for drug safety are crucial for helping to avoid costly late-stage failures. We review recent work on models for genotoxicity, liver toxicity, CYP450 inhibition and cardiotoxicity. These models have improved somewhat in recent years
Autor:
Edward G. Bartick, Randolph C. Galipo, Mark L. Miller, Stephen L. Morgan, Brian K. Kochanowski, Robert F. Mothershead, William J. Egan, Dennis C. Ward
Publikováno v:
Analytical and Bioanalytical Chemistry. 376:1286-1297
Copy toner samples were analyzed using scanning electron microscopy with X-ray dispersive analysis (SEM-EDX) and pyrolysis gas chromatography/mass spectrometry (Py-GC/MS). Principal component and cluster analysis of SEM data for 166 copy toner sample
Autor:
William J. Egan, Georgio Lauri
Publikováno v:
Advanced Drug Delivery Reviews. 54:273-289
This review focuses on computational methods for the prediction of passive intestinal permeability. Existing computational models are surveyed and assessed in terms of descriptors, model type/complexity, speed of computation, predictive performance,
Autor:
William J. Egan, George Lauri, Ailan Cheng, Steven L. Dixon, David J. Diller, Kenneth M. Merz
Publikováno v:
Journal of Computational Chemistry. 23:172-183
Very large data sets of molecules screened against a broad range of targets have become available due to the advent of combinatorial chemistry. This information has led to the realization that ADME (absorption, distribution, metabolism, and excretion
Autor:
Roland E. Dolle, Linda O’Brien, Marc Orlowski, John C. Reader, Cullen L. Cavallaro, Ying Jin, William J. Egan, Wenni Li, Mark Piznik, Joan Guo, Biji Jacob-Samuel, Carolyn DiIanni Carroll, Andrew Laird Roughton, Kevin J. Bowman, Qian Zhao
Publikováno v:
Journal of Combinatorial Chemistry. 2:716-731
A statistical sampling protocol is described to assess the fidelity of libraries encoded with molecular tags. The methodology, termed library QA, is based on the combined application of tag decode analysis and single bead LC/MS. The physical existenc
Publikováno v:
Journal of Medicinal Chemistry. 43:3867-3877
Literature data on compounds both well- and poorly-absorbed in humans were used to build a statistical pattern recognition model of passive intestinal absorption. Robust outlier detection was utilized to analyze the well-absorbed compounds, some of w
Publikováno v:
Journal of Chemometrics. 15:29-48
Improvements in the computational neural network modeling process are described with the goals of enhancing the optimization process and reducing NN model complexity. Improvements to the optimization process not only speed computation, but also can e
Publikováno v:
Applied Spectroscopy. 53:439-447
Luminescence and Raman measurements of metal (Er3+, Tb3+, Sm3+, Eu3+, UO22+, and Na+) nitrates from multiple spectral windows are combined and analyzed to determine whether this multispectral approach provides any benefit over the best single-measure