Zobrazeno 1 - 6 of 6 pro vyhledávání: '"William Issa"'
1
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
Autor: Xiao Feng, Changjiang Yu, Katherine Macfarlane, Giang Thanh Le, Eric Dale Jones, John Deadman, David Ian Rhodes, Neeranat Thienthong, Nick Vandegraaff, Long Lu, Xinming Li, Lisa Jane Winfield, Jonathan Coates, Neil Choi, William Issa
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:5913-5917
HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71f90d1f2b9956a6092f9c40795a171
https://doi.org/10.1016/j.bmcl.2010.07.079
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2
Synthesis of 11C labelled methyl esters: transesterification of enol esters versus BF3 catalysed esterification—a comparative study
Autor: Cheryl L. Falzon, Henri Tochon-Danguy, Paul Blanc, Andrew M. Scott, John I. Sachinidis, Uwe Ackermann, William Issa, Jonathan M. White
Publikováno v: Radiation Physics and Chemistry. 75:48-52
C-11 labelled methyl esters have been synthesized via the transesterification of enol esters in the presence of C-11 methanol and 1,3 dichlorodibutylstannoxane as catalyst. This method leaves functional groups intact and allows access to a wider vari
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a415d11b69874c34f8e92daa3c434a7e
https://doi.org/10.1016/j.radphyschem.2005.05.019
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3
Silicon-directed acid ring-opening of allyltrimethylsilane oxide. X-ray structures of 3-triisopropylsilyl-2-(2,4-dinitrobenzoyloxy)-1-propanol and 3-triisopropylsilyl-2-(2,4,6-trinitrobenzoyloxy)-1-propanol
Autor: Brett R. Pool, William Issa, Fatmir Badali, Jonathan M. White
Publikováno v: Journal of Organometallic Chemistry. 575:251-260
Allyltrimethylsilane oxide 5 undergoes regiospecific ring-opening with carboxylic acids in chloroform to give the hydroxy esters 6a–e. In polar solvents competing elimination results in the formation of allyl alcohol. Allyltriisopropylsilane oxide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::687d1923e987130206f4e0ea286ae702
https://doi.org/10.1016/s0022-328x(98)01002-x
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6
Influence of Trimethylsilyl Substituents on Primary C - O Bond Lengths at the b-Position: Results from Low-Temperature X-Ray Structural Studies
Autor: Alison J. Green, William Issa, Jonathan M. White
Publikováno v: Australian Journal of Chemistry. 50:927
The β-trimethylsilyl substituent in 2-trimethylsilylethyl p-nitrobenzoate (12b) and 2-trimethylsilylethyl 2,4-dinitrobenzenesulfenate (12c) leads to significant lengthening of the C(alkyl)–O(ester) bond. Lengthening of the Si-CH2 distance in the m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c8cd896bee1bfdb20290fcadea456a5
https://doi.org/10.1071/c97056
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