Zobrazeno 1 - 10
of 67
pro vyhledávání: '"William I. Wood"'
Publikováno v:
Nucleic Acids Research
GeneHub-GEPIS is a web application that performs digital expression analysis in human and mouse tissues based on an integrated gene database. Using aggregated expressed sequence tag (EST) library information and EST counts, the application calculates
Autor:
Racquel Corpuz, James Lee, Daryl T. Baldwin, Austin L. Gurney, Richard Vandlen, Wei-Hsien Ho, Miko Maruoka, Jessica Foster, Daniel G. Yansura, William I. Wood, Audrey Goddard
Publikováno v:
Journal of Biological Chemistry. 276:1660-1664
We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple
Autor:
Jeremy Stinson, Zemin Zhang, Austin L. Gurney, Sudeepta Aggarwal, Wei-Hsien Ho, William I. Wood, Audrey Goddard, Ming-Hong Xie, Jessica Foster
Publikováno v:
Journal of Biological Chemistry. 275:31335-31339
We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22. IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family. No high af
Autor:
Jian Chen, Sherry Heldens, Arthur J Huang, Austin L. Gurney, Jessica Foster, Patrick Dowd, Jeremy Stinson, Hanzhong Li, William I. Wood
Publikováno v:
Proceedings of the National Academy of Sciences. 97:773-778
IL-17 is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Whereas expression of IL-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a
Autor:
A. Gurney, R.M. Pitti, Melanie R. Mark, Arthur J Huang, Alane M. Gray, Patrick Dowd, Paulj. Godowski, S. Marsters, K.P. Baker, Daryl T. Baldwin, A.D. Goddard, Jennifer Brush, Peter Schow, Sherry Heldens, Avi Ashkenazi, William I. Wood
Publikováno v:
Current Biology. 9(4):215-218
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation, differentiation, and survival [1] [2] [3]. We have identified a new TNF-related ligand, designated human G
Autor:
James P. Sheridan, Kevin P. Baker, Scot A. Marsters, Audrey Goddard, Paul J. Godowski, Daryl T. Baldwin, Austin L. Gurney, Christa L. Gray, William I. Wood, Maya Skubatch, Robert M. Pitti, Avi Ashkenazi, Lakshmi Ramakrishnan
Publikováno v:
Science. 277:818-821
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (
Autor:
Yi-Ding Wang, Andrew C. Larner, Rebecca H. Hackett, Sharon M. Sweitzer, William I. Wood, Gerald M. Feldman
Publikováno v:
Journal of Biological Chemistry. 272:11128-11132
It has been previously demonstrated that growth hormone (GH)-stimulated tyrosine phosphorylation of Jak2 and Stat5a and Stat5b occurs in FDP-C1 cells expressing either the entire GH receptor or truncations of the cytoplasmic domain expressing only th
Publikováno v:
Cytokine & Growth Factor Reviews. 7:81-91
In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1) was identified by coupling expression cloning with an embryonic stem cell-based model of cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines
Autor:
Ann B. Vernallis, Mikiyoshi Saito, William I. Wood, Kai C. Wollert, Tetsuya Taga, Kenneth R. Chien, Masashi Narazaki, John K. Heath, Diane Pennica, Tadamitsu Kishimoto, Christopher C. Glembotski
Publikováno v:
Journal of Biological Chemistry. 271:9535-9545
Cardiotrophin-1 (CT-1) was recently isolated by expression cloning based on its ability to induce an increase in cell size in neonatal rat ventricular cardiomyocytes. Sequence similarity data suggested that CT-1 is a novel member of a family of struc
Publikováno v:
Journal of Biological Chemistry. 268:12617-12623
The human growth hormone (GH) receptor contains an extracellular hormone-binding domain of about 246 amino acids, a single transmembrane domain, and a cytoplasmic region of 350 residues. X-ray crystallographic and functional data show that a single G