Zobrazeno 1 - 7
of 7
pro vyhledávání: '"William Hawse"'
Autor:
Jishnu Das, Greg Delgoffe, Diwakar Davar, Stacy Wendell, Hector Nieves-Rosado, Bingxian Xie, Kristin Morder, Abigail E Overacre-Delgoffe, Drew Wilfahrt, Douglas Prado, Madison Nguyen, William Hawse, Larry Kane
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/be8d9a0267ee49a1ac5247c566d6bffb
Autor:
Rachael A. Gordon, Christina Giannouli, Chirag Raparia, Sheldon I. Bastacky, Anthony Marinov, William Hawse, Richard Cattley, Jeremy S. Tilstra, Allison M. Campbell, Kevin M. Nickerson, Anne Davidson, Mark J. Shlomchik
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated phagocytosis (LAP). The
Externí odkaz:
https://doaj.org/article/3c1ff191a0484eb9a817b3dcb6dde47f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2252787a725e43b0b39335ddf0857951
Publikováno v:
The Journal of Immunology. 194:201.15-201.15
Antigen stimulation of the T cell receptor (TCR) in a naïve T cell triggers a complex network of signaling pathways that determine whether the cell becomes a tolerogenic T regulatory (Treg) or immunogenic T helper (TH) cell. We previously developed
Autor:
William Hawse, Penelope Morel
Publikováno v:
The Journal of Immunology. 194:201.3-201.3
Akt/mTOR signaling influences CD4+ T cell differentiation; low levels favor Treg induction and high levels favor Th induction. Here, we identify several key elements in this pathway that are differentially regulated by TCR signal strength, including
Publikováno v:
The Journal of Immunology. 192:63.8-63.8
Naïve CD4+ T cells differentiate into either helper (Th) or regulatory (Treg) cells following encounter with antigen. T cell fate is in part determined by signaling strength where lower TCR and AKT/mTOR signaling favors Treg differentiation and high
Publikováno v:
The Journal of Immunology. 192:63.1-63.1
We have recently published a mathematical model that demonstrates that differential activation of signaling pathways downstream of TCR by high and low concentrations of antigen can be modeled by varying the duration of antigen stimulation, which resu