Zobrazeno 1 - 10
of 183
pro vyhledávání: '"William Harnett"'
Autor:
Margaret M. Harnett, James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Josephine Duncombe-Moore, Geraldine Buitrago, Piaopiao Pan, Paul A. Hoskisson, Colin Selman, William Harnett
Publikováno v:
Frontiers in Tropical Diseases, Vol 4 (2024)
The parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis
Externí odkaz:
https://doaj.org/article/683e487bd806486f86d7ba45a7f58b53
Autor:
Margaret M. Harnett, Felicity E. Lumb, Jenny Crowe, James Doonan, Geraldine Buitrago, Stephanie Brown, Gillian Thom, Amy MacDonald, Colin J. Suckling, Colin Selman, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mice develop pathology in the lungs as they age and this may be accelerated by a high calorie diet (HCD). ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is immunomodulatory by virtue of covalently attached phosphorylc
Externí odkaz:
https://doaj.org/article/e3ecfaf3645f4e8596b6d32606f6e458
Autor:
Margaret M. Harnett, James Doonan, Felicity E. Lumb, Jenny Crowe, Roel Olde Damink, Geraldine Buitrago, Josephine Duncombe-Moore, Debbie I. Wilkinson, Colin J. Suckling, Colin Selman, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite significant increases in human lifespan over the last century, adoption of high calorie diets (HCD) has driven global increases in type-2 diabetes, obesity and cardiovascular disease, disorders precluding corresponding improvements in healths
Externí odkaz:
https://doaj.org/article/523ab5246f8f4ce380e052b716596cff
Autor:
Marlene Corbet, Miguel A. Pineda, Kun Yang, Anuradha Tarafdar, Sarah McGrath, Rinako Nakagawa, Felicity E. Lumb, Colin J. Suckling, William Harnett, Margaret M. Harnett
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema viteae. The molecule exists as a large tetramer (MW, ~240kD), which possesses immunomodulatory properties by virtue of multiple phosphorylcholine (PC) moieties
Externí odkaz:
https://doaj.org/article/88da2086d64c47acae3e522a690425a6
Autor:
James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Felicity E. Lumb, Jenny Crowe, Aneesah M. Khan, Paul A. Hoskisson, Margaret M. Harnett, William Harnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Gastrointestinal infection with parasitic helminths can protect against mucosal diseases via impacting on the microbiome. Here the authors show that ES-62, a product secreted by a tissue-resident helminth modulates the host gut microbiome to protect
Externí odkaz:
https://doaj.org/article/8765710fbb1b48aea36aa040ff1dbf77
Autor:
Jenny Crowe, Felicity E Lumb, James Doonan, Margaux Broussard, Anuradha Tarafdar, Miguel A Pineda, Carmen Landabaso, Lorna Mulvey, Paul A Hoskisson, Simon A Babayan, Colin Selman, William Harnett, Margaret M Harnett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008391 (2020)
Improvements in hygiene and health management have driven significant increases in human lifespan over the last 50 years. Frustratingly however, this extension of lifespan has not been matched by equivalent improvements in late-life health, not least
Externí odkaz:
https://doaj.org/article/2771c56a5ed84259b37550f07c50890c
Autor:
Felicity E. Lumb, James Doonan, Kara S. Bell, Miguel A. Pineda, Marlene Corbet, Colin J. Suckling, Margaret M. Harnett, William Harnett
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract ES-62, a glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae, subverts host immune responses towards anti-inflammatory phenotypes by virtue of covalently attached phosphorylcholine (PC). The PC dictates that ES-
Externí odkaz:
https://doaj.org/article/630b811b03324ca2ba57f8104374c764
Autor:
Margaret M. Harnett, Miguel A. Pineda, Perle Latré de Laté, Russell J. Eason, Sébastien Besteiro, William Harnett, Gordon Langsley
Publikováno v:
Biomedical Journal, Vol 40, Iss 1, Pp 9-22 (2017)
Christian de Duve first coined the expression “autophagy” during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of
Externí odkaz:
https://doaj.org/article/2948d31d73ee497581f6e5cfd1be66d8
Autor:
Perle Laté de Laté, Miguel Pineda, Margaret Harnett, William Harnett, Sébastien Besteiro, Gordon Langsley
Publikováno v:
Biomedical Journal, Vol 40, Iss 1, Pp 23-30 (2017)
Apicomplexan parasites are responsible for a number of important human pathologies. Obviously, as Eukaryotes they share a number of cellular features and pathways with their respective host cells. One of them is autophagy, a process involved in the d
Externí odkaz:
https://doaj.org/article/6d7d62a523514b11acb3de736aa794c4
Publikováno v:
Metabolites, Vol 10, Iss 10, p 413 (2020)
Previous research has shown that propolis has immunomodulatory activity. Extracts from two UK propolis samples were assessed for their anti-inflammatory activities by investigating their ability to alter the production of the cytokines: tumour necros
Externí odkaz:
https://doaj.org/article/0bed00a5bb18452780e3605c2a8c1118