Zobrazeno 1 - 10
of 14
pro vyhledávání: '"William H. Yutzy"'
Autor:
Yiping Zhang, Mirit I. Aladjem, Jiuping Ji, Akira Yuno, Haobin Chen, Lan Tran, Susan E. Bates, Sunmin Lee, James H. Doroshow, Robert J. Kinders, Min-Jung Lee, Seth M. Steinberg, Yves Pommier, Christine Alewine, Anish Thomas, Christophe E. Redon, Linda Sciuto, Raffit Hassan, Eva Szabo, Emerson Padiernos, William H. Yutzy, Jane B. Trepel, Udayan Guha, Arun Rajan
Publikováno v:
Journal of Clinical Oncology. 36:1594-1602
Purpose Our preclinical work identified depletion of ATR as a top candidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors. We hypothesized that a combination of selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6075e9de7ef838c0a5ae9286bc769a2e
https://doi.org/10.1200/jco.2017.76.6915
https://doi.org/10.1200/jco.2017.76.6915
Autor:
Jiuping J. Ji, Alice P. Chen, Brad A. Gouker, Ralph E. Parchment, Shivaani Kummar, James H. Doroshow, Kristina M. Bigelow, Robert J. Kinders, Katherine V. Ferry-Galow, Scott M. Lawrence, Deborah Wilsker, Donna Butcher, Thomas D. Pfister, William H. Yutzy, Hala R. Makhlouf, Allison M. Marrero
Publikováno v:
Seminars in Oncology. 43:484-491
Robust pharmacodynamic assay results are valuable for informing go/no-go decisions about continued development of new anti-cancer agents and for identifying combinations of targeted agents, but often pharmacodynamic results are too incomplete or vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccc4493db2f40c861156f5996ecb459
https://doi.org/10.1053/j.seminoncol.2016.06.006
https://doi.org/10.1053/j.seminoncol.2016.06.006
Autor:
Joseph E. Tomaszewski, Martin Gutierrez, Thomas D. Pfister, Ralph E. Parchment, Robert J. Kinders, Julianne L. Holleran, Yves Pommier, Julie L. Eiseman, Larry Rubinstein, James H. Doroshow, Joseph M. Covey, Jan H. Beumer, Shivaani Kummar, Jiuping Ji, Christophe E. Redon, Yiping Zhang, William H. Yutzy, Jerry M. Collins, Alice P. Chen, Deborah Allen, Lihua Wang, William M. Bonner
Publikováno v:
Cancer Chemotherapy and Pharmacology. 78:73-81
Indenoisoquinolines are non-camptothecin topoisomerase I (TopI) inhibitors that overcome the limitations of camptothecins: chemical instability and camptothecin resistance. Two dosing schedules of the novel indenoisoquinoline, indotecan (LMP400), wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ca0a6003288dc534387b70c9d42de8
https://doi.org/10.1007/s00280-016-2998-6
https://doi.org/10.1007/s00280-016-2998-6
Publikováno v:
Cancer Research. 66:6807-6815
An elevated number of Gr-1+CD11b+ myeloid cells has been described in mice bearing transplantable tumors, and has been associated with immune suppression. We examined the role of such myeloid suppressor cells in mice bearing the spontaneously transfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd69f17a279b82ebc4239aa1f204534
https://doi.org/10.1158/0008-5472.can-05-3755
https://doi.org/10.1158/0008-5472.can-05-3755
Autor:
Brigitte M. Ronnett, Tzyy Choou Wu, Andrea Elko, Patti E. Gravitt, Steven Piantadosi, Chien Fu Hung, Shiwen Peng, Richard W. Daniel, Barbara Wilgus, Cornelia L. Trimble, Keerti V. Shah, Drew M. Pardoll, Richard B.S. Roden, Ellen S. Pizer, William H. Yutzy
Publikováno v:
Clinical Cancer Research. 11:4717-4723
Purpose: Persistent infection with oncogenic human papillomaviruses (HPV) plays a central etiologic role in the development of squamous carcinomas of the cervix and their precursor lesions, cervical intraepithelial neoplasias (CIN). We carried out a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fea18234a310dc2e3f22125556f5a7
https://doi.org/10.1158/1078-0432.ccr-04-2599
https://doi.org/10.1158/1078-0432.ccr-04-2599
Autor:
Rongcun Yang, Satoshi Uematsu, R. Lee Blosser, Michael Delannoy, Shizuo Akira, Francisco Martinez Murillo, Kiyoshi Takeda, Raphael P. Viscidi, Richard B.S. Roden, William H. Yutzy
Publikováno v:
The Journal of Immunology. 174:7912-7919
Vaccination with human papillomavirus type 16 (HPV16) L1 virus-like particles (VLP) induces both high titer neutralizing IgG and protective immunity. Because protection from experimental infection by papillomavirus is mediated by neutralizing IgG, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5ebe4f69cd3792ca9c5887519e2463
https://doi.org/10.4049/jimmunol.174.12.7912
https://doi.org/10.4049/jimmunol.174.12.7912
Autor:
Kiyoshi Takeda, Richard B.S. Roden, Ken Yu Lin, Raphael P. Viscidi, Rongcun Yang, Shizuo Akira, William H. Yutzy, Francisco Martinez Murillo, Satoshi Uematsu
Publikováno v:
The Journal of Immunology. 173:2624-2631
Human papillomavirus type-16 (HPV16) L1 virus-like particles (VLPs) activate dendritic cells (DCs) and induce protective immunity. In this study, we demonstrate, using global gene expression analysis, that HPV16 VLPs produce quite distinct innate res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21985449c25d627c7cd431450687823b
https://doi.org/10.4049/jimmunol.173.4.2624
https://doi.org/10.4049/jimmunol.173.4.2624
Autor:
Richard B.S. Roden, Ken Yu Lin, Rongcun Yang, William H. Yutzy, Chien Fu Hung, Patricia M. Day
Publikováno v:
Journal of Virology. 77:3531-3541
Human papillomavirus type 16 (HPV16) is the primary etiologic agent of cervical carcinoma, whereas bovine papillomavirus type 1 (BPV1) causes benign fibropapillomas. However, the capsid proteins, L1 and L2, of these divergent papillomaviruses exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f11430eaebb0023be40a8b83bcdc84a
https://doi.org/10.1128/jvi.77.6.3531-3541.2003
https://doi.org/10.1128/jvi.77.6.3531-3541.2003
Positively Charged Termini of the L2 Minor Capsid Protein Are Necessary for Papillomavirus Infection
Autor:
William H. Yutzy, Patricia M. Day, Brian K. Bronzo, Douglas R. Lowy, Yanqin Yang, John T. Schiller, Richard B.S. Roden
Publikováno v:
Journal of Virology. 75:10493-10497
Coexpression of bovine papillomavirus L1 with L2 mutants lacking either eight N-terminal or nine C-terminal amino acids that encode positively charged domains resulted in wild-type levels of viral genome encapsidation. Despite wild-type binding to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af6f199d0b40b36d02f65142df5f9a1
https://doi.org/10.1128/jvi.75.21.10493-10497.2001
https://doi.org/10.1128/jvi.75.21.10493-10497.2001
Autor:
Rosemary Fallon, Douglas R. Lowy, Richard B.S. Roden, Stephen C. Inglis, John T. Schiller, William H. Yutzy
Publikováno v:
Virology. 270:254-257
Vaccination with virus-like particles (VLP), comprising both L1 and L2 of human papillomavirus (HPV) genital types 6, 16, and 18, induces predominantly type-specific neutralizing antibodies. L2 polypeptide vaccines protect animals against experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede1953e5168d22416a48185391397fa
https://doi.org/10.1006/viro.2000.0272
https://doi.org/10.1006/viro.2000.0272