Zobrazeno 1 - 10
of 41
pro vyhledávání: '"William H. Wheat"'
Autor:
Juan M. Belardinelli, Divya Arora, Charlotte Avanzi, William H. Wheat, Josephine M. Bryant, John S. Spencer, Tom L. Blundell, Julian Parkhill, R. Andres Floto, Mary Jackson
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Functional genomics analysis of Mycobacterium abscessus clinical isolates from chronically infected patients to identify genes under strong evolutionary pressure during lung adaptation identified phoR as one of the most frequently mutated. p
Externí odkaz:
https://doaj.org/article/2bf422acc9ed4da6817771c9620be1e0
Autor:
William H. Wheat, Lyndah Chow, Alyssa M. Betlach, Maria Pieters, Jade Kurihara, Cooper Dow, Valerie Johnson, Franklyn B. Garry, Steven Dow
Publikováno v:
Animals, Vol 13, Iss 10, p 1686 (2023)
Given the rapid potential spread of agricultural pathogens, and the lack of vaccines for many, there is an important unmet need for strategies to induce rapid and non-specific immunity against these viral and bacterial threats. One approach to the pr
Externí odkaz:
https://doaj.org/article/e125262b6b2644dfb60c446359918530
Autor:
David W. Markman, Michael F. Antolin, Richard A. Bowen, William H. Wheat, Michael Woods, Mercedes Gonzalez-Juarrero, Mary Jackson
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 2, Pp 294-302 (2018)
Plague ecology is characterized by sporadic epizootics, then periods of dormancy. Building evidence suggests environmentally ubiquitous amebae act as feral macrophages and hosts to many intracellular pathogens. We conducted environmental genetic surv
Externí odkaz:
https://doaj.org/article/87358601d90a439baf0d95d7583179d6
Supplemental Figure S2. PD-L1 antibody treatment of human macrophages results in phenotypic changes consistent with those seen in murine macrophages. Macrophages were treated with medium only, an irrelevant isotype antibody, or PD-L1 antibody for 6 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9423f37ba087164a8b8228878a5bafde
https://doi.org/10.1158/2326-6066.22536440.v1
https://doi.org/10.1158/2326-6066.22536440.v1
Legends for supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b62bae4608bc831f62c16074b9ea684
https://doi.org/10.1158/2326-6066.22536422.v1
https://doi.org/10.1158/2326-6066.22536422.v1
Tumor-associated macrophages (TAMs) express programmed cell death ligand 1 (PD-L1) and contribute to the immune-suppressive tumor microenvironment. Although the role of the PD-L1 and PD-1 interaction to regulate T-cell suppression is established, les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ead8729cf0ce68088c7b62569c90ae
https://doi.org/10.1158/2326-6066.c.6548141.v1
https://doi.org/10.1158/2326-6066.c.6548141.v1
Autor:
John S Spencer, Malcolm S Duthie, Annemieke Geluk, Marivic F Balagon, Hee Jin Kim, William H Wheat, Delphi Chatterjee, Mary Jackson, Wei Li, Jade N Kurihara, Armi Maghanoy, Irene Mallari, Paul Saunderson, Patrick J Brennan, Hazel M Dockrell
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 107, Iss suppl 1, Pp 79-89 (2012)
Although leprosy is curable with drug treatment, the identification of biomarkers of infection, disease progression and treatment efficacy would greatly help to reduce the overall prevalence of the disease. Reliable biomarkers would also reduce the i
Externí odkaz:
https://doaj.org/article/3f07fa210aca4869a48e32001f658e3f
Publikováno v:
Microbiology. 166:695-706
Biofilm-associated infections are difficult to eradicate because of their ability to tolerate antibiotics and evade host immune responses. Amoebae and/or their secreted products may provide alternative strategies to inhibit and disperse biofilms on b
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
BMC Research Notes
BMC Research Notes
Objective Rhizoctonia solani is a soil-borne fungal pathogen of many important crop plants. In rice, R. solani causes sheath blight disease, which results in devastating grain yield and quality losses. Few methods are available to control this pathog
Autor:
Lyndah Chow, Jade N. Kurihara, Sirikul Soontararak, Steven W. Dow, Michael R. Lappin, William H. Wheat, Alana R Kuzmik
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-13 (2019)
BMC Veterinary Research
BMC Veterinary Research
Background Non-specific immunotherapeutics have been evaluated previously in dogs, primarily for cancer treatment. However, there remains a need for a more broadly targeted, general purpose immunotherapeutic capable of activating innate immune defens