Zobrazeno 1 - 10
of 21
pro vyhledávání: '"William H. Towns"'
Autor:
Georgette N. Jones, Chhavy Tep, William H. Towns, II, Georgeta Mihai, Ian D. Tonks, Graham F. Kay, Petra M. Schmalbrock, Anat O. Stemmer-Rachamimov, Sung Ok Yoon, Lawrence S. Kirschner
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 11, Pp 1213-1221 (2008)
Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results f
Externí odkaz:
https://doaj.org/article/061bca0d7c204629a76294534d83b8d2
Autor:
Erin Hertlein, Kyle A Beckwith, Gerard Lozanski, Timothy L Chen, William H Towns, Amy J Johnson, Amy Lehman, Amy S Ruppert, Brad Bolon, Leslie Andritsos, Arletta Lozanski, Laura Rassenti, Weiqiang Zhao, Tiina M Jarvinen, Leigha Senter, Carlo M Croce, David E Symer, Albert de la Chapelle, Nyla A Heerema, John C Byrd
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76607 (2013)
Studies of chronic lymphocytic leukemia (CLL) have yielded substantial progress, however a lack of immortalized cell lines representative of the primary disease has hampered a full understanding of disease pathogenesis and development of new treatmen
Externí odkaz:
https://doaj.org/article/6701b5761778490aa7e468949244dd8d
Autor:
Xiaoli Zhang, William H. Towns, Sabrina L Garman, Callie M. Drohan, Brad Bolon, Gerard Lozanski, Mark E. Lustberg, Amy Lehman, Robert A. Baiocchi, Michael R. Grever, Li Pan, A. Douglas Kinghorn, David M. Lucas, John T. Patton
Publikováno v:
Oncotarget
Treatment options for patients with Epstein-Barr Virus-driven lymphoproliferative diseases (EBV-LPD) are limited. Chemo-immunotherapeutic approaches often lead to immune suppression, risk of lethal infection and EBV reactivation, thus it is essential
Autor:
Kami J. Maddocks, Carolyn Cheney, Gerard Lozanski, Carlo M. Croce, Leslie A. Andritsos, William H. Towns, Jeffrey A. Jones, Matthew R. Stefanovski, Frank Frissora, Jutta Deckert, Natarajan Muthusamy, Joseph M. Flynn, John C. Byrd, Kyle A. Beckwith, Xiaokui Mo
Publikováno v:
Leukemia
Therapeutic regimens for chronic lymphocytic leukemia (CLL) have increasingly utilized monoclonal antibodies since the chimeric anti-CD20 antibody rituximab was introduced. Despite improved clinical outcomes, current CLL therapies are not curative. T
Autor:
Yicheng Mao, Matthew R. Stefanovski, Xiaokui Mo, Erin Hertlein, Mitch A. Phelps, Ly James Lee, John C. Byrd, Guido Marcucci, Natarajan Muthusamy, Robert J. Lee, David Jarjoura, Georgia Triantafillou, William H. Towns, David M. Goldenberg
Publikováno v:
Clinical Cancer Research. 19:347-356
Purpose: Corticosteroids are widely used for the treatment of B-cell malignancies, including non–Hodgkin lymphoma, chronic lymphocytic leukemia (CLL), and acute lymphoblastic leukemia; however, this class of drug is associated with undesirable off-
Autor:
Xiaoli Zhang, Lapo Alinari, Robert A. Baiocchi, Michael R. Grever, Li Pan, David Jarjoura, William H. Towns, Amy Lehman, David M. Lucas, Courtney J. Prince, A. Douglas Kinghorn, Ryan B. Edwards, Rajeswaran Mani
Publikováno v:
Clinical Cancer Research. 18:4600-4611
Purpose: During cell-cycle progression, D-cyclins activate cyclin-dependent kinases (CDKs) 4/6 to inactivate Rb, permitting E2F1-mediated S-phase gene transcription. This critical pathway is typically deregulated in cancer, and novel inhibitory strat
Autor:
Xiaoli Zhang, David Jarjoura, Erin Hertlein, Thomas S. Lin, Kami J. Maddocks, William H. Towns, Amy J. Johnson, Derek A. West, John C. Byrd, Carlo M. Croce, Virginia M. Goettl, Jeffrey A. Jones, Chelsey A. Raymond, Amy J. Wagner
Publikováno v:
Blood. 116:45-53
The HSP90 client chaperone interaction stabilizes several important enzymes and antiapoptotic proteins, and pharmacologic inhibition of HSP90 results in rapid client protein degradation. Therefore, HSP90 inhibition is an attractive therapeutic approa
Autor:
Philip F. Binkley, Georgette N. Jones, Xiaoli Zhang, Lawrence S. Kirschner, Zhirong Yin, E. Dale Abel, William H. Towns, David Jarjoura
Publikováno v:
Circulation. 117:1414-1422
Background— Protein kinase A signaling has long been known to play an important role in cardiac function. Dysregulation of the protein kinase A system, caused by mutation of the protein kinase A regulatory subunit gene PRKAR1A , causes the inherite
Autor:
Lawrence S. Kirschner, J. Aidan Carney, Donna F. Kusewitt, William H. Towns, Constantine A. Stratakis, Heiner Westphal, Ludmila Matyakhina
Publikováno v:
Cancer Research. 65:4506-4514
Carney complex is an autosomal dominant neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and schwannomas. This condition may be caused by inactivating mutations in PRKAR1A, the gene encoding the type 1A reg
Autor:
William J. Murphy, David H. Munn, Benjamin H. Kaffenberger, Henry K. Wong, Ivan Maillard, Jerome Ritz, Jason A. Dubovsky, Steven M. Devine, Laurence Elias, Jonathan S. Serody, Yiming Zhong, Geoffrey R. Hill, Carrie Yang, Bonnie K. Harrington, Corey Cutler, Bruce R. Blazar, Ryan Flynn, John C. Byrd, Natarajan Muthusamy, Jing Du, Joseph H. Antin, K. MacDonald, William H. Towns, Angela Panoskaltsis-Mortari, John Koreth, Amy Lehman, Amy J. Johnson, Leo Luznik, Samantha Jaglowski, Robert J. Soiffer
Publikováno v:
The Journal of clinical investigation, vol 124, iss 11
Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not completely prevent and/or treat cGVHD. CD4+ T cells and B cells mediate cGVHD; therefore, t