Zobrazeno 1 - 10
of 162
pro vyhledávání: '"William H. Prusoff"'
Publikováno v:
Antiviral Research. 85:34-38
The occasion of this 25th anniversary issue encouraged us to reminisce about the important history of the discovery of the dideoxynucleoside analogues for the treatment of HIV/AIDS and to chronicle our thoughts about a particular exciting and rewardi
Autor:
Wade S. Blair, Arman D Pivazyan, Donald S. Matteson, Rajendra P. Singh, Levente Fabry-Asztalos, William H. Prusoff, Kenny Guo, Brett S. Robinson, Pin-Fang Lin
Publikováno v:
Biochemical Pharmacology. 60:927-936
Six boronated tetrapeptides with the carboxy moiety of phenylalanine replaced by dihydroxyboron were synthesized, and their activities against human immunodeficiency virus 1 (HIV-1) protease subsequently investigated. The sequences of these peptides
Autor:
Liang Huang, Rocco Carbone, Yikang Si, Kemei Wu, William H. Prusoff, Evelyn M. Birks, Ju-Liang Zhu, Raymond F. Schinazi, Tai-Shun Lin
Publikováno v:
Biochemical Pharmacology. 46:251-255
We previously reported that the racemic mixture and both enantiomers of gossypol inhibit the replication of human immunodeficiency virus-type 1 (HIV-1) (Lin et al., Antimicrob Agents Chemother 33: 2149-2151, 1989). The present study evaluates the act
Publikováno v:
Pharmacology & Therapeutics. 60:315-329
The human immunodeficiency virus, HIV-1, is generally accepted to be responsible for AIDS. It is imperative that all approaches, empirical and rational, be taken for development of a drug for therapy of this disease. These approaches are discussed, w
Autor:
E. Michael August, William H. Prusoff, Lin Tai-Shun, Evelyn M. Birks, Qian He-Ying, Usha A. Thombre
Publikováno v:
Biochemical Pharmacology. 45:223-230
3'-Azido-2',3'-dideoxy-5-iodouridine (AzIdUrd) and 3'-azido-2',3'-dideoxy-5-bromouridine (AzBdUrd), previously shown to be potent and selective inhibitors of human immunodeficiency virus replication in vitro were minimally toxic to the uninfected hum
Autor:
William R. Mancini, Eric J. Gabe, William H. Prusoff, Regina H. Clarke-Katzenburg, Tai Shun Lin, George I. Birnbaum, Mei Zhen Luo, M.‐C. Liu, J. Giziewicz, Yung-Chi Cheng
Publikováno v:
ChemInform. 23
Various 2'- and 3'-methylidene-substituted nucleoside analogues have been synthesized and evaluated as potential anticancer and/or antiviral agents. Among these compounds, 2'-deoxy-2'-methylidene-5-fluorocytidine (22) and 2'-deoxy-2'-methylidenecytid
Autor:
I. Ghazzouli, Yung-Chi Cheng, J.‐S. Feng, Shen Zy, George I. Birnbaum, V. Brankovan, G.‐D. Hsiung, J. Giziewicz, J.‐H. Yang, Mao-Chin Liu, Tai-Shun Lin, William H. Prusoff
Publikováno v:
ChemInform. 22
Autor:
William H. Prusoff
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:xv-xvii
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:1315-1321
The syntheses of [2-14C] 2,5′-anhydro-3′-azido-3′-deoxythymidine and [2-14C] 2,5′-anhydro-3′-azido-2′,3′-dideoxy-5-iodouridine in a one pot operation under mild conditions are described.
Autor:
Shen Zy, I. Ghazzouli, J. Giziewicz, Mao-Chin Liu, George I. Birnbaum, J.‐H. Yang, Brankovan, Yung-Chi Cheng, Tai-Shun Lin, William H. Prusoff
Publikováno v:
Journal of Medicinal Chemistry. 34:693-701
Various 3'-deoxy pyrimidine nucleoside analogues have been synthesized for evaluation as potential anticancer and antiviral agents. Among these compounds, 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine (10, 3'-deoxy-ara-C) and 3'-deoxycytidine (22)