Zobrazeno 1 - 10
of 95
pro vyhledávání: '"William H. Parsons"'
Autor:
Zongtao Lin, Xie Wang, Katelyn A. Bustin, Kyosuke Shishikura, Nate R. McKnight, Lin He, Radu M. Suciu, Kai Hu, Xian Han, Mina Ahmadi, Erika J. Olson, William H. Parsons, Megan L. Matthews
Publikováno v:
ACS Central Science, Vol 7, Iss 9, Pp 1524-1534 (2021)
Externí odkaz:
https://doaj.org/article/8f82974812a345d89a744fbecfd2dd7e
Autor:
Nate R McKnight, Mina Ahmadi, Katelyn A. Bustin, Xian Han, Lin He, Kai Hu, Kyosuke Shishikura, Radu M. Suciu, William H. Parsons, Megan L. Matthews, Erika J. Olson, Zongtao Lin, Xie Wang
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 9, Pp 1524-1534 (2021)
ACS Central Science, Vol 7, Iss 9, Pp 1524-1534 (2021)
Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that tag a single type of nucleophilic amino acid to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba034a6907d34fa33cc472445c9152a
http://europepmc.org/articles/PMC8461768
http://europepmc.org/articles/PMC8461768
Autor:
Dan Tan, Nhi Ngo, Justin Wang, Joan Vaughan, Cassandra L. Henry, Meric Erikci Ertunc, Micah J. Niphakis, Aundrea R. Coppola, Benjamin F. Cravatt, Antonio Pinto, Kenneth M. Lum, Cynthia J. Donaldson, William H. Parsons, Bernard P. Kok, Alan Saghatelian, Enrique Saez
Publikováno v:
J Biol Chem
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4414fcfebb83fa1a2e2bc9e8086a042
https://doi.org/10.1074/jbc.ra119.012145
https://doi.org/10.1074/jbc.ra119.012145
Autor:
Gabriel M. Simon, Pablo Lara-Gonzalez, Benjamin F. Cravatt, Kenneth M. Lum, Michael Petrascheck, Daisuke Ogasawara, Arshad Desai, William H. Parsons, Armand B. Cognetta, Liron Bar-Peled, Alice L Chen, Alan To
Publikováno v:
Nature Chemical Biology. 15:453-462
Phenotypic screening has identified small-molecule modulators of aging, but the mechanism of compound action often remains opaque due to the complexities of mapping protein targets in whole organisms. Here, we combine a library of covalent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612f44bd64a03a8f1a5f85c5056f4047
https://doi.org/10.1038/s41589-019-0243-4
https://doi.org/10.1038/s41589-019-0243-4
Autor:
William H. Parsons, Megan L. Matthews, Zongtao Lin, Eric S. Witze, Ann M. Gregus, Nancy Schek, Radu M. Suciu, Erika J. Olson, Mina Ahmadi, Katelyn A. Bustin, Xie Wang, Matthew W. Buczynski, Kai Hu, Lin He, Paul D. Morton
Known chemoproteomic probes generally use warheads that tag a single type of amino acid or modified form thereof to identify cases in which its hyper-reactivity underpins function. Much important biochemistry derives from electron-poor enzyme cofacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cc363bc1007f4bcb6e7aa57762843d6
https://doi.org/10.1101/2020.06.17.154864
https://doi.org/10.1101/2020.06.17.154864
Autor:
William H. Parsons, Alyssa S. Chow, Nicholas T. Rutland, Charlotte L. Andrews, Jennifer A. Crainic, Joaquin M. Cardozo, Brendan K. Sheehan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 49:128290
While the biochemistry of rhomboid proteases has been extensively studied since their discovery two decades ago, efforts to define the physiological roles of these enzymes are ongoing and would benefit from chemical probes that can be used to manipul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5557b64728abccdb4df5c7e8a752e9d2
https://doi.org/10.1016/j.bmcl.2021.128290
https://doi.org/10.1016/j.bmcl.2021.128290
Autor:
Cynthia J. Donaldson, William H. Parsons, Enrique Saez, Nhi Ngo, Meric Erikci Ertunc, Benjamin F. Cravatt, Kenneth M. Lum, Antonio F. M. Pinto, Joan Vaughan, Micah J. Niphakis, Aundrea R. Coppola, Justin Wang, Alan Saghatelian, Cassandra L. Henry, Dan Tan, Bernard P. Kok
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dc63ab69b2a9cab9ced245cead737d5
https://doi.org/10.1096/fasebj.2020.34.s1.04337
https://doi.org/10.1096/fasebj.2020.34.s1.04337
Publikováno v:
Nature chemical biology
More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a6bf44220fbe2f72e5a16479e30b7
https://doi.org/10.1038/nchembio.2127
https://doi.org/10.1038/nchembio.2127
Publikováno v:
Angewandte Chemie International Edition. 53:5760-5784
The paralytic agent (+)-saxitoxin (STX), most commonly associated with oceanic red tides and shellfish poisoning, is a potent inhibitor of electrical conduction in cells. Its nefarious effects result from inhibition of voltage-gated sodium channels (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85868c1009ed3a82cbfd23607e6e8be7
https://doi.org/10.1002/anie.201308235
https://doi.org/10.1002/anie.201308235
Autor:
William H. Parsons, J. Du Bois
Publikováno v:
Journal of the American Chemical Society. 135:10582-10585
(+)-Saxitoxin, a naturally occurring guanidinium poison, functions as a potent, selective, and reversible inhibitor of voltage-gated sodium ion channels (NaVs). Modified forms of this toxin bearing cysteine-reactive maleimide groups are available thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd91b7dd4b667c4f606f152457f047c
https://doi.org/10.1021/ja4019644
https://doi.org/10.1021/ja4019644