Zobrazeno 1 - 10
of 29
pro vyhledávání: '"William H. Nugent"'
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 52, Iss 1, Pp 114-121 (2024)
AbstractAcute respiratory distress syndrome (ARDS) is a complication of pulmonary disease that produces life-threatening hypoxaemia. Despite ventilation and hyperoxic therapies, undetected hypoxia can manifest in capillary beds leading to multi-organ
Externí odkaz:
https://doaj.org/article/852d64c0c2f943f0b265bca11a9cc58d
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 51, Iss 1, Pp 33-40 (2023)
AbstractSepsis is a devastating complication of infection and injury that, through widespread endothelial dysfunction, can cause perfusion deficits and multi-organ failure. To address the recognised need for therapeutics targetting the endothelial ba
Externí odkaz:
https://doaj.org/article/e0770210539d428bbe50109ae786a9ba
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
This study examined changes in interstitial PO2, which allowed calculation of VO2 during periods of rest, muscle contraction and recovery using an in situ rat spinotrapezius muscle preparation. The PO2 was measured using phosphorescence quenching mic
Externí odkaz:
https://doaj.org/article/eafa129a94254062acf99af64a2ff952
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 49, Iss 1, Pp 709-716 (2021)
Acute respiratory distress syndrome (ARDS) features pulmonary dysfunction capable of causing life-threatening hypoxaemia. Ventilation and hyperoxic therapies force oxygen through dysfunctional alveoli but risk exacerbating damage. Ox66™ is an inges
Externí odkaz:
https://doaj.org/article/dc4cb4968003468eb6d64cc245010b0f
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 48, Iss 1, Pp 1079-1088 (2020)
Medical support for traumatic haemorrhage is lacking for far-forward combat units. VIR-HBOC (haemoglobin-based oxygen carrier) is a novel biological therapeutic under development as a field-stable resuscitation fluid. HBOCs have a long history of com
Externí odkaz:
https://doaj.org/article/508b27af921a48daa076080fed69307e
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 95-103 (2019)
Hypoxia drives sickle cell disease (SCD) by inducing sickle cell haemoglobin to polymerize and deform red blood cells (RBC) into the sickle shape. A novel carboxyhaemoglobin-based oxygen carrier (PEG-COHb; PP-007) promotes unsickling in vitro by reli
Externí odkaz:
https://doaj.org/article/f6eb8f10d809490c970dc0328a9c532a
Autor:
Kellie J. Archer, William H. Nugent, Marwah Al Dulaimi, Scott W. Walsh, Sonya L. Washington, Jerome F. Strauss
Publikováno v:
Reprod Sci
DNA methylation is an epigenetic mechanism controlling gene expression, and reduced methylation is associated with increased gene expression. We hypothesized that IL-17 cytokines are regulated by DNA methylation, are elevated in the circulation of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45ed48a109e0e755930978a14aca8d8
https://doi.org/10.1007/s43032-021-00605-3
https://doi.org/10.1007/s43032-021-00605-3
Publikováno v:
Journal of Applied Physiology. 128:1579-1586
Hemolytic anemia (HA) is reduced blood oxygen-carrying capacity resulting from the depletion of red blood cells. Treatment for severe cases involves transfusion to improve oxygen delivery (Do2), which carries risk. In humans, a total hemoglobin (tHb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdc4d891e24bddd2677f2cc463c0bce
https://doi.org/10.1152/japplphysiol.00767.2019
https://doi.org/10.1152/japplphysiol.00767.2019
Autor:
Forest R. Sheppard, Abe Abuchowski, Daniel N. Darlington, Ronald Jubin, Ramon F. Cestero, Bjorn K. Song, William H. Nugent, Michael A. Dubick
Publikováno v:
Shock. 53:493-502
BACKGROUND Hemorrhage is the leading cause of preventable, traumatic death. Currently, prehospital resuscitation fluids provide preload but not oxygen-carrying capacity-a critical blood function that mitigates microvascular ischemia and tissue hypoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97b5b70c5b3d4da01c3161d9afd0edc
https://doi.org/10.1097/shk.0000000000001370
https://doi.org/10.1097/shk.0000000000001370
Publikováno v:
Military medicine.
Introduction Pulmonary dysfunction (PD) and its associated hypoxia present a complication to the care of many service members and can arise intrinsically via comorbidities or extrinsically by infection or combat-related trauma (burn, smoke inhalation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002437c03dd55b15e05c0fa806980e98
https://pubmed.ncbi.nlm.nih.gov/35284916
https://pubmed.ncbi.nlm.nih.gov/35284916