Zobrazeno 1 - 10
of 312
pro vyhledávání: '"William H. McBride"'
Autor:
Prabhat K. Purbey, Joowon Seo, Manash K. Paul, Keisuke S. Iwamoto, Allison E. Daly, An-Chieh Feng, Ameya S. Champhekar, Justin Langerman, Katie M. Campbell, Dörthe Schaue, William H. McBride, Steven M. Dubinett, Antoni Ribas, Stephen T. Smale, Philip O. Scumpia
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114289- (2024)
Summary: Type I interferon (IFN-I) and IFN-γ foster antitumor immunity by facilitating T cell responses. Paradoxically, IFNs may promote T cell exhaustion by activating immune checkpoints. The downstream regulators of these disparate responses are i
Externí odkaz:
https://doaj.org/article/1aacdb1bc8d04f2aac55bcac0e7d97b6
Autor:
Dörthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1649 (2022)
Nuclear factor erythroid 2-related factor 2 (NRF2) is recognized as a master transcription factor that regulates expression of numerous detoxifying and antioxidant cytoprotective genes. In fact, models of NRF2 deficiency indicate roles not only in re
Externí odkaz:
https://doaj.org/article/d93c14d74c3a4a43a4f52aa740921de6
Autor:
Ewa D. Micewicz, Robert D. Damoiseaux, Gang Deng, Adrian Gomez, Keisuke S. Iwamoto, Michael E. Jung, Christine Nguyen, Andrew J. Norris, Josephine A. Ratikan, Piotr Ruchala, James W. Sayre, Dörthe Schaue, Julian P. Whitelegge, William H. McBride
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We previously reported several vignettes on types and classes of drugs able to mitigate acute and, in at least one case, late radiation syndromes in mice. Most of these had emerged from high throughput screening (HTS) of bioactive and chemical drug l
Externí odkaz:
https://doaj.org/article/51771cf263924ecca3296a531a0d3deb
Autor:
Keisuke S. Iwamoto, PhD, Robert E. Sandstrom, MD, Mark Bryan, EdM, Yue Liu, PhD, S. Robin Elgart, PhD, Ke Sheng, PhD, Michael L. Steinberg, MD, William H. McBride, DSc, Daniel A. Low, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 3, Pp 100645- (2021)
Purpose: The clinical efficacy of radiation therapy is mechanistically linked to ionization-induced free radicals that cause cell and tissue injury through direct and indirect mechanisms. Free radical reaction dynamics are influenced by many factors
Externí odkaz:
https://doaj.org/article/09bd2ef75e0c48eaba3967ae6c9af553
Autor:
Silvia C. Formenti, Rachael E. Hawtin, Neha Dixit, Erik Evensen, Percy Lee, Judith D. Goldberg, Xiaochun Li, Claire Vanpouille-Box, Dörthe Schaue, William H. McBride, Sandra Demaria
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Background We previously reported the results of a multicentric prospective randomized trial of chemo-refractory metastatic breast cancer patients testing the efficacy of two doses of TGFβ blockade during radiotherapy. Despite a lack of obj
Externí odkaz:
https://doaj.org/article/e6b2d5724ebd4e2aa865a8b4b39e445d
Autor:
Helicia Paz, Jennifer Tsoi, Anusha Kalbasi, Catherine S. Grasso, William H. McBride, Dörthe Schaue, Lisa H. Butterfield, Deena M. Maurer, Antoni Ribas, Thomas G. Graeber, James S. Economou
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Various proinflammatory cytokines can be detected within the melanoma tumor microenvironment. Interleukin 32 (IL32) is produced by T cells, NK cells and monocytes/macrophages, but also by a subset of melanoma cells. We sought to b
Externí odkaz:
https://doaj.org/article/d5d7f5fae5e844ecb39f49f1e3b53245
Autor:
Jean Philippe Nesseler, MD, Dorthe Schaue, PhD, William H. McBride, PhD, DSc, Mi-Heon Lee, PhD, Tania Kaprealian, MD, Simone P. Niclou, PhD, Philippe Nickers, MD, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 4, Iss 2, Pp 268-282 (2019)
Purpose: Glioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for imm
Externí odkaz:
https://doaj.org/article/7874013381ef4aa4b84a30f7c17e7b00
Autor:
Helena Escuin-Ordinas, Shuoran Li, Michael W. Xie, Lu Sun, Willy Hugo, Rong Rong Huang, Jing Jiao, Felipe Meira de-Faria, Susan Realegeno, Paige Krystofinski, Ariel Azhdam, Sara Marie D. Komenan, Mohammad Atefi, Begoña Comin-Anduix, Matteo Pellegrini, Alistair J. Cochran, Robert L. Modlin, Harvey R. Herschman, Roger S. Lo, William H. McBride, Tatiana Segura, Antoni Ribas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the
Externí odkaz:
https://doaj.org/article/4df7cfd06ae5433d88273671aa9365b6
Autor:
Jean Philippe Nesseler, Mi-Heon Lee, Christine Nguyen, Anusha Kalbasi, James W. Sayre, Tahmineh Romero, Philippe Nickers, William H. McBride, Dörthe Schaue
Publikováno v:
Cancers, Vol 12, Iss 3, p 714 (2020)
The purpose of this study was to determine the dynamic contributions of different immune cell subsets to primary and abscopal tumor regression after hypofractionated radiation therapy (hRT) and the impact of anti-PD-1 therapy. A bilateral syngeneic F
Externí odkaz:
https://doaj.org/article/ebecdd9f900445cc8236a92072eb1da9
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 12, Pp 1122-1129 (2007)
BACKGROUND: Cancer anemia causes fatigue and correlates with poor treatment outcome. Erythropoietin has been introduced in an attempt to correct these defects. However, five recent clinical trials reported a negative impact of erythropoietin on survi
Externí odkaz:
https://doaj.org/article/17518b70858141f68c4f6cf03577581a