Zobrazeno 1 - 10
of 214
pro vyhledávání: '"William H. Klein"'
Autor:
Takae Kiyama, Ye Long, Ching-Kang Chen, Christopher M. Whitaker, Allison Shay, Hongyu Wu, Tudor C. Badea, Amir Mohsenin, Jan Parker-Thornburg, William H. Klein, Stephen L. Mills, Stephen C. Massey, Chai-An Mao
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 900-915.e5 (2019)
Summary: In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional characteristics. RGCs arise from a common pool of retinal progenitor cells during embryoni
Externí odkaz:
https://doaj.org/article/9c325aa44e9d4b08967f1de839af1fac
Publikováno v:
BioTechniques, Vol 27, Iss 1, Pp 154-163 (1999)
A lacZ transgene, expressed by the myogenin promoter, was introduced into the mouse hypoxanthine phosphoribosyltransferase (Hprt) locus by gene targeting in embryonic stem cells. Embryos between E10.5—E18.5 days were analyzed for expression of the
Externí odkaz:
https://doaj.org/article/dd9e4353de0442d5af06805e3e12b926
Autor:
Monica P. Colaiácovo, Bruce A. Yankner, Joseph M. Zullo, David A. Bennett, William H. Klein, Derek Drake, Patrick O’Hern, Noah Davidsohn, Sameer C. Dhamne, Liviu Aron, Chai An Mao, George M. Church, Alexander Rotenberg
Publikováno v:
Nature
The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1f4c9e899ecb12eaf11ee13d60691c
https://doi.org/10.1038/s41586-019-1647-8
https://doi.org/10.1038/s41586-019-1647-8
Autor:
William H. Klein, Allison Shay, Amir Mohsenin, Christopher M. Whitaker, Stephen L. Mills, Takae Kiyama, Chai An Mao, Ye Long, Tudor C. Badea, Stephen C. Massey, Jan Parker-Thornburg, Hongyu Wu, Ching-Kang Chen
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 900-915.e5 (2019)
Summary: In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional characteristics. RGCs arise from a common pool of retinal progenitor cells during embryoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9a9631921906669b88ac3cdecf557e
http://www.sciencedirect.com/science/article/pii/S2211124719304164
http://www.sciencedirect.com/science/article/pii/S2211124719304164
Publikováno v:
Development
Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret-expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips to generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f53fb8471fe8f7b9666d6e6ad45f28
https://pubmed.ncbi.nlm.nih.gov/33914865
https://pubmed.ncbi.nlm.nih.gov/33914865
Autor:
Chai An Mao, William H. Klein, Takae Kiyama, Zhenlin Ju, Jing Wang, Ching-Kang Chen, Shinako Takada, Steven W. Wang, Ping Pan
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2018)
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2018)
Background Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer retina, photoreceptors are particularly vulnerable to mutations affecting mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8d926389afb522a0df46b71050dc99
https://doi.org/10.1186/s13024-018-0287-z
https://doi.org/10.1186/s13024-018-0287-z
Autor:
Shaohong Cheng, Shunzhen Zhang, Rajiv Dixit, Jimmy de Melo, Carol Schuurmans, Qi Zhang, Jeffrey T. Wigle, David D. Eisenstat, Nadean L. Brown, Jamie Zagozewski, William H. Klein, Xiuqian Mu
Publikováno v:
Development.
Regulated retinal ganglion cell (RGC) differentiation and axonal guidance is required for a functional visual system. Homeodomain and basic helix-loop-helix transcription factors are required for retinogenesis, as well as patterning, differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53dca48611c331e3ee174881131ea31c
https://doi.org/10.1242/dev.142042
https://doi.org/10.1242/dev.142042
Publikováno v:
Developmental Neurobiology. 74:1123-1140
The bHLH transcription factor ATOH7 (Math5) is essential for establishing retinal ganglion cell (RGC) fate. However, Atoh7-expressing retinal progenitor cells (RPCs) can give rise to all retinal cell types, suggesting that other factors are involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709e75d67546a15c230e930e8c705bce
https://doi.org/10.1002/dneu.22188
https://doi.org/10.1002/dneu.22188
Autor:
Qi, Zhang, Jamie, Zagozewski, Shaohong, Cheng, Rajiv, Dixit, Shunzhen, Zhang, Jimmy, de Melo, Xiuqian, Mu, William H, Klein, Nadean L, Brown, Jeffrey T, Wigle, Carol, Schuurmans, David D, Eisenstat
Publikováno v:
Development (Cambridge, England)
Regulated retinal ganglion cell (RGC) differentiation and axonal guidance is required for a functional visual system. Homeodomain and basic helix-loop-helix transcription factors are required for retinogenesis, as well as patterning, differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85af6c452ef11b8075457521f03654d6
https://pubmed.ncbi.nlm.nih.gov/28356311
https://pubmed.ncbi.nlm.nih.gov/28356311
Autor:
Rumiko, Mizuguchi, Hiromi, Naritsuka, Kensaku, Mori, Chai-An, Mao, William H, Klein, Yoshihiro, Yoshihara
Publikováno v:
Journal of Neuroscience. 32:8831-8844
The olfactory bulb (OB) is the first relay station in the brain where odor information from the olfactory epithelium is integrated, processed through its intrinsic neural circuitry, and conveyed to higher olfactory centers. Compared with profound mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb555e17ced98cddd548838109517d3b
https://doi.org/10.1523/jneurosci.5746-11.2012
https://doi.org/10.1523/jneurosci.5746-11.2012