Zobrazeno 1 - 10 of 41 pro vyhledávání: '"William H. Isacoff"'
1
ChemoSensitivity Assay Guided Metronomic Chemotherapy Is Safe and Effective for Treating Advanced Pancreatic Cancer
Autor: William H. Isacoff, Brandon Cooper, Andrew Bartlett, Brian McCarthy, Kenneth H. Yu
Publikováno v: Cancers; Volume 14; Issue 12; Pages: 2906
Cytotoxic chemotherapy remains the mainstay of treatment for advanced pancreatic adenocarcinoma (PDAC). Emerging studies support metronomic chemotherapy (MCT) as effective, challenging established paradigms of dosing and schedules. The blood-based Ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f4248605cdfb2f8f43575761d3c7a8
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2
Pharmacogenomic blood-based assay to predict chemotherapy response and survival in pancreatic cancer
Autor: Kenneth H. Yu, Fay M. Purcell, Brian C. McCarthy, Eileen M. O'Reilly, Devan McCarthy, Jennifer Park, William H. Isacoff, Brandon Cooper, Andrew Bartlett
Publikováno v: Journal of Clinical Oncology. 38:738-738
738 Background: Pancreatic adenocarcinoma (PDAC) is for most patients a refractory disease. Modern cytotoxic chemotherapeutics (C) are not yet optimal for inducing responses and extending life. We are developing a blood-based pharmacogenomic (PGx) as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e8c69280fcdf9e11fc1a44f14d0a833
https://doi.org/10.1200/jco.2020.38.4_suppl.738
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3
Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis
Autor: William Arthur Hoos, Lola Rahib, Timothy R. Donahue, O. Joe Hines, Alexander Upfill-Brown, Rudolph A. Bedford, Howard A. Reber, William H. Isacoff
Publikováno v: Targeted oncology, vol 13, iss 4
Targeted Oncology
BackgroundContinuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer. As a protracted low-dose infusion, 5FU is antiangiogenic, and has synergy w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6245bfdfbfa54e0425ad4e7f95243957
https://escholarship.org/uc/item/8725b6g9
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4
Impact of Tumor Grade on Pancreatic Cancer Prognosis: Validation of a Novel TNMG Staging System
Autor: James S. Tomlinson, Zev A. Wainberg, O. Joe Hines, Timothy R. Donahue, Jacob S. Ankeny, Matthew M. Rochefort, William H. Isacoff, Brian E. Kadera, Howard A. Reber, Graham W. Donald
Publikováno v: Rochefort, MM; Ankeny, JS; Kadera, BE; Donald, GW; Isacoff, W; Wainberg, ZA; et al.(2013). Impact of Tumor Grade on Pancreatic Cancer Prognosis: Validation of a Novel TNMG Staging System. ANNALS OF SURGICAL ONCOLOGY, 20(13), 4322-4329. doi: 10.1245/s10434-013-3159-3. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3xw82449
Annals of surgical oncology, vol 20, iss 13
BackgroundPancreatic ductal adenocarcinoma (PDAC) patients demonstrate highly variable survival within each stage of the American Joint Committee on Cancer (AJCC) staging system. We hypothesize that tumor grade is partly responsible for this variatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104ddea6541a11bd4e06463f0c4bc4bd
https://doi.org/10.1245/s10434-013-3159-3
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5
Impact of Splenectomy on Thrombocytopenia, Chemotherapy, and Survival in Patients with Unresectable Pancreatic Cancer
Autor: William H. Isacoff, Howard A. Reber, Kevork Kazanjian, Timothy R. Donahue, O. Joe Hines
Publikováno v: Journal of Gastrointestinal Surgery
Donahue, Timothy R.; Kazanjian, Kevork K.; Isacoff, William H.; Reber, Howard A.; & Hines, O. Joe. (2010). Impact of Splenectomy on Thrombocytopenia, Chemotherapy, and Survival in Patients with Unresectable Pancreatic Cancer. Journal of Gastrointestinal Surgery, 14(6), pp 1012-1018. doi: 10.1007/s11605-010-1187-x. Retrieved from: http://www.escholarship.org/uc/item/6gf7s3cc
Background Patients with unresectable pancreatic cancer (PDAC) or endocrine tumors (PET) often develop splenic vein thrombosis, hypersplenism, and thrombocytopenia which limits the administration of chemotherapy. Methods From 2001 to 2009, 15 patient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20ddfadbbff0ab709ed3954049207c4
http://europepmc.org/articles/PMC2872015
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6
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor
Autor: David A. Dezentje, Michael J. Swartz, Michiel S. van der Heijden, Angelo M. DeMarzo, G. Johan A. Offerhaus, Jonathan R. Brody, Scott E. Kern, William H. Isacoff, Steven C. Cunningham, Eike Gallmeier, Ralph H. Hruban
Publikováno v: Clinical cancer research, 11(20), 7508-7515. American Association for Cancer Research Inc.
Purpose: BRCA2, FANCC, and FANCG gene mutations are present in a subset of pancreatic cancer. Defects in these genes could lead to hypersensitivity to interstrand cross-linkers in vivo and a more optimal treatment of pancreatic cancer patients based
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa85f462785256ddfb5dadc541f10e7d
https://doi.org/10.1158/1078-0432.ccr-05-1048
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7
Evaluation of a cell viability assay based on cultures of CTICs to identify treatment options in third-line pancreatic cancer
Autor: Allyson J. Ocean, William H. Isacoff, Kenneth H. Yu, Mark Ricigliano, Mary Welkie, Andrew Bartlett, Brandon Cooper
Publikováno v: Journal of Clinical Oncology. 35:338-338
338 Background: Standard of care treatment for pancreatic adenocarcinoma (PDAC) includes FOLFIRINOX or gemcitabine with nab-paclitaxel used in either the front-line or 2nd line treatment setting. There is no consensus for 3rd line treatment for this
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https://doi.org/10.1200/jco.2017.35.4_suppl.338
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8
Endoscopic Ultrasound Does Not Accurately Assess Pathologic Stage of Esophageal Cancer after Neoadjuvant Chemoradiotherapy
Autor: Bryce D. Beseth, Rudolph Bedford, William H. Isacoff, E. Carmack Holmes, Robert B. Cameron
Publikováno v: The American Surgeon. 66:827-831
The accuracy of endoscopic ultrasound (EUS) for initial staging of esophageal cancer is widely accepted. There is, however, considerable variability in the reported accuracy of EUS for restaging of esophageal neoplasms after neoadjuvant therapy. From
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa44bde3a653da3a15ad12945aa66041
https://doi.org/10.1177/000313480006600905
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10
Chemotherapy for the Treatment of Patients with Metastatic Colorectal Cancer: An Overview
Autor: William H. Isacoff, Katrina Borud
Publikováno v: World Journal of Surgery. 21:748-762
Approximately 50% of patients with colorectal cancer develop locally recurrent or distant metastatic disease during the course of their illness and eventually die. Since the 1950s the mainstay of treatment for patients in need of palliative therapy h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3285a95e79482863280606d3dbbe3d64
https://doi.org/10.1007/s002689900301
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