Zobrazeno 1 - 10
of 148
pro vyhledávání: '"William H. Gmeiner"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 734 (2024)
Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved survival outcomes over the last several decades with much of the therapeutic bene
Externí odkaz:
https://doaj.org/article/2ce954d0ef6a4901bb86567a037194cc
Publikováno v:
ACS Omega, Vol 5, Iss 44, Pp 28463-28474 (2020)
Externí odkaz:
https://doaj.org/article/b1dbad2f43994dd485d6de26740f7971
Autor:
Chinnadurai Mani, Shirisha Jonnalagadda, Jojireddy Lingareddy, Sanjay Awasthi, William H. Gmeiner, Komaraiah Palle
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background Breast cancer remains as one of the most lethal types of cancer in women. Among various subtypes, triple-negative breast cancer (TNBC) is the most aggressive and hard to treat type of breast cancer. Mechanistically, increased DNA
Externí odkaz:
https://doaj.org/article/63ccb4a51a8e47938273acfb56ab4b11
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 12, Pp 1236-1245 (2018)
We are developing the fluoropyrimidine polymer F10 to overcome limitations of 5-fluorouracil (5-FU) that result from inefficient metabolism to 5-fluoro-2′-deoxyuridine-5′-mono- and tri-phosphate, the deoxyribonucleotide metabolites that are respo
Externí odkaz:
https://doaj.org/article/c506598f91ae4db7837356cee67eff0c
Autor:
Upasana Das, Aditi Sahoo, Subhash Haldar, Sudin Bhattacharya, Syam Sundar Mandal, William H. Gmeiner, Supratim Ghosh
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 14349-14360 (2018)
Externí odkaz:
https://doaj.org/article/57cbee248870439682e55a7fe548ed69
Autor:
William H. Gmeiner
Publikováno v:
Molecules, Vol 25, Iss 15, p 3438 (2020)
We review developments in fluorine chemistry contributing to the more precise use of fluorinated pyrimidines (FPs) to treat cancer. 5-Fluorouracil (5-FU) is the most widely used FP and is used to treat > 2 million cancer patients each year. We review
Externí odkaz:
https://doaj.org/article/c1fd3199a0a64ae3a9fd08b4ad06593b
Publikováno v:
Journal of Nucleic Acids, Vol 2011 (2011)
Topoisomerase 1 (Top1) enzymes regulate DNA superhelicity by forming covalent cleavage complexes that undergo controlled rotation. Substitution of nucleoside analogs at the +1 position of the DNA duplex relative to the Top1 cleavage site inhibits DNA
Externí odkaz:
https://doaj.org/article/750e52c6bb934f349072ab7d61525691
Publikováno v:
Cancer Drug Resistance. 6:257-272
The emergence of chemoresistant disease during chemotherapy with 5-Fluorouracil-based (5-FU-based) regimens is an important factor in the mortality of metastatic CRC (mCRC). The causes of 5-FU resistance are multi-factorial, and besides DNA mismatch
Autor:
Jonathan R. Brody, William H. Gmeiner, Charles J. Yeo, Komaraiah Palle, Talia Golan, Lebaron C. Agostini, Avinoam Nevler, Chinnadurai Mani, Aditi Jain, Alex O. Haber
AraC-FdUMP[10] (CF10) is a second-generation polymeric fluoropyrimidine that targets both thymidylate synthase (TS), the target of 5-fluorouracil (5-FU), and DNA topoisomerase 1 (Top1), the target of irinotecan, two drugs that are key components of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbeb761e931f5550b765a86612d1904c
https://doi.org/10.1158/1541-7786.c.6545126.v1
https://doi.org/10.1158/1541-7786.c.6545126.v1
Autor:
Jonathan R. Brody, William H. Gmeiner, Charles J. Yeo, Komaraiah Palle, Talia Golan, Lebaron C. Agostini, Avinoam Nevler, Chinnadurai Mani, Aditi Jain, Alex O. Haber
S1. (A) Representative graph of 5-day picogreen survival assay with PDX139, a patient derived xenograft line. (B) Representative images of 10-day colony growth inhibition assays with crystal violet staining in indicated PDAC cell lines. (C) Graph of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c297fc72f9734b6d4226904ebc294ef
https://doi.org/10.1158/1541-7786.22526537.v1
https://doi.org/10.1158/1541-7786.22526537.v1