Zobrazeno 1 - 10
of 248
pro vyhledávání: '"William H. Frey"'
Autor:
Ayala Kobo-Greenhut, Hilel Frankenthal, Aziz Darawsha, Avraham Karasik, Adit Zohar Beja, Tamir Ben Hur, Dana Ekstein, Lisa Amir, Daniel Shahaf, Izhar Ben Shlomo, Iris Shichor, William H. Frey
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 1754-1763 (2022)
Current literature lacks structured methodologies for analyzing medical technologies’ impact from the patient-centered care perspective. This study introduces, applies and validates ‘Patient-Centered Care Impact Analysis’ (PCIA) as a method for
Externí odkaz:
https://doaj.org/article/9796a6adb695409dba661076edc33ff1
Autor:
David C. Yeomans, Leah R. Hanson, Dean S. Carson, Brendan J. Tunstall, Mary R. Lee, Alexander Z. Tzabazis, Daniel Jacobs, William H. Frey
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain and various psychiatric disorders, however, there is scant evidence that oxytocin reaches the brain. We quantified the concentration and distribu
Externí odkaz:
https://doaj.org/article/941b748b10d24d72a4c41802e25eb95e
Autor:
Lalitha R. Belur, Megan Romero, Junggu Lee, Kelly M. Podetz-Pedersen, Zhenhong Nan, Maureen S. Riedl, Lucy Vulchanova, Kelley F. Kitto, Carolyn A. Fairbanks, Karen F. Kozarsky, Paul J. Orchard, William H. Frey, Walter C. Low, R. Scott McIvor
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Mucopolysaccharidosis type I (MPS I) is an inherited metabolic disorder caused by deficiency of the lysosomal enzyme alpha-L-iduronidase (IDUA). The two current treatments [hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy
Externí odkaz:
https://doaj.org/article/612b20e3a1914626b04655208aae2b85
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 551 (2022)
The aim of this study was to examine the relationship between the presence of glucose hypometabolism (GHM) and brain iron accumulation (BIA), two potential pathological mechanisms in neurodegenerative disease, in different regions of the brain in peo
Externí odkaz:
https://doaj.org/article/cfb3f0bae3004ccd99fa2dd464d9ae45
Autor:
Lusine Danielyan, Matthias Schwab, Georg Siegel, Bianca Brawek, Olga Garaschuk, Nithi Asavapanumas, Marine Buadze, Ali Lourhmati, Hans-Peter Wendel, Meltem Avci-Adali, Marcel A. Krueger, Carsten Calaminus, Ulrike Naumann, Stefan Winter, Elke Schaeffeler, Annett Spogis, Sandra Beer-Hammer, Jonas J. Neher, Gabriele Spohn, Anja Kretschmer, Eva-Maria Krämer-Albers, Kerstin Barth, Hong Jun Lee, Seung U. Kim, William H. Frey, II, Claus D. Claussen, Dirk M. Hermann, Thorsten R. Doeppner, Erhard Seifried, Christoph H. Gleiter, Hinnak Northoff, Richard Schäfer
Publikováno v:
EBioMedicine, Vol 60, Iss , Pp 102989- (2020)
Background: Stem cells` (SC) functional heterogeneity and its poorly understood aetiology impedes clinical development of cell-based therapies in regenerative medicine and oncology. Recent studies suggest a strong correlation between the SC migration
Externí odkaz:
https://doaj.org/article/50fadaeaeb26482dbe9ab2d00b7b2fef
Autor:
Jared M. Fine, Jacob Kosyakovsky, Amanda M. Baillargeon, Julian V. Tokarev, Jacob M. Cooner, Aleta L. Svitak, Katherine A. Faltesek, William H. Frey II, Leah R. Hanson
Publikováno v:
Brain and Behavior, Vol 10, Iss 3, Pp n/a-n/a (2020)
Abstract Introduction Intranasal deferoxamine (IN DFO) has been shown to decrease memory loss and have beneficial impacts across several models of neurologic disease and injury, including rodent models of Alzheimer's and Parkinson's disease. Methods
Externí odkaz:
https://doaj.org/article/ddb5a9d4b46347c0abe5269c4f0e207b
Autor:
Henning Johannes Drews, Roman Klein, Ali Lourhmati, Marine Buadze, Elke Schaeffeler, Thomas Lang, Torgom Seferyan, Leah R. Hanson, William H. Frey II, Tom C.G.M. de Vries, Inge A.E.W. Thijssen-van Loosdregt, Christoph H. Gleiter, Matthias Schwab, Lusine Danielyan
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 166 (2021)
Angiotensin receptor blockers (ARBs) have demonstrated multiple neuroprotective benefits in Alzheimer’s disease (AD) models. However, their beneficial effects on memory deficits, cholinergic activity, neurogenesis and Amyloid beta (Aβ) clearance r
Externí odkaz:
https://doaj.org/article/cb8ce661db5e47dbb9279035a139c9e7
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 95 (2021)
Identifying disease-modifying therapies for neurological diseases remains one of the greatest gaps in modern medicine. Herein, we present the rationale for intranasal (IN) delivery of deferoxamine (DFO), a high-affinity iron chelator, as a treatment
Externí odkaz:
https://doaj.org/article/a26d39a7966e4d1ca7cac70db418906b
Autor:
Gayane Hrachia Buniatian, Ralf Weiskirchen, Thomas S. Weiss, Ute Schwinghammer, Martin Fritz, Torgom Seferyan, Barbara Proksch, Michael Glaser, Ali Lourhmati, Marine Buadze, Erawan Borkham-Kamphorst, Frank Gaunitz, Christoph H. Gleiter, Thomas Lang, Elke Schaeffeler, Roman Tremmel, Holger Cynis, William H. Frey, Rolf Gebhardt, Scott L. Friedman, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan
Publikováno v:
Cells, Vol 9, Iss 2, p 452 (2020)
The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal a
Externí odkaz:
https://doaj.org/article/cc2a91c9344d42779f90fae7ec9cc22f
Autor:
Zhongwu Liu, Yi Li, Li Zhang, Hongqi Xin, Yisheng Cui, Leah R. Hanson, William H. Frey, II, Michael Chopp
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 2, Pp 804-809 (2012)
As a thrombolytic agent, application of recombinant tissue plasminogen activator (tPA) to ischemic stroke is limited by the narrow time window and side effects on brain edema and hemorrhage. This study examined whether tPA, administered by intranasal
Externí odkaz:
https://doaj.org/article/294c14729a6d4ab08bffe58e282f9ba7