Výsledky vyhledávání - "William H. Doub"

Addressing the Need for Controls on Particle Bounce and Re-entrainment in the Cascade Impactor and for the Mitigation of Electrostatic Charge for Aerodynamic Particle Size Assessment of Orally Inhaled Products: an Assessment by the International Consortium on Regulation and Science (IPAC-RS)

Autor: William H. Doub, Adrian Goodey, Stephen W. Stein, Jolyon P. Mitchell

Publikováno v: AAPS PharmSciTech. 21

Multi-stage cascade impactors (CI) are accepted for the determination of metrics of the drug mass aerodynamic particle size distributions (APSD) of aerosols emitted from orally inhaled products (OIPs). This is particularly important for products wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645eaff21b399335c2c1afaa78d3b509
https://doi.org/10.1208/s12249-020-01720-1

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Scope and relevance of a pulmonary biopharmaceutical classification system AAPS/FDA/USP Workshop March 16-17th, 2015 in Baltimore, MD

Autor: Masahiro Sakagimi, Anthony J. Hickey, Jason T. McConville, Phil J. Kuehl, Andrew Reginald Clark, Jayne E. Hastedt, Peter J. Mauser, William H. Doub, Jeffry G. Weers, Claus-Michael Lehr, Ralph Niven, Guenther Hochhaus, Per Bäckman

Publikováno v: AAPS Open, Vol 2, Iss 1, Pp 1-20 (2016)

The Biopharmaceutics Classification System (BCS), developed in the 1990s for oral immediate release drugs, is utilized by R&D scientists and regulators to streamline product development and regulatory approval timelines. This elegant, science-based a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379d2586398df4aa75f39d20636106c9
http://link.springer.com/article/10.1186/s41120-015-0002-x

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Valved Holding Chambers and In Vitro Metered Dose Inhaler Performance: Effects of Flow Rate and Inhalation Delay

Autor: Alan Schroeder, Peter R. Starke, William H. Doub, Changning Guo, Badrul A. Chowdhury, Prasad Peri, Susan Limb, Xiaofei Liu

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery. 30(6)

Multiple factors may influence the performance of a metered dose inhaler (MDI) when used with a valved holding chamber (VHC or "spacer").Andersen Cascade Impactor measurements were conducted for three MDI products and two different VHCs using a speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32058ec15d406c374676579dcaff4d72
https://pubmed.ncbi.nlm.nih.gov/28846482

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Evaluation of an Abbreviated Impactor for Fine Particle Fraction (FPF) Determination of Metered Dose Inhalers (MDI)

Autor: Diem Ngo, William H. Doub, Shafiq S. Ahadi, Changning Guo

Publikováno v: AAPS PharmSciTech. 14:1004-1011

Abbreviated impactors have been developed recently to allow more rapid evaluation of inhalation products as alternates to the eight-stage Andersen Cascade Impactor (ACI) which has been widely used in the pharmaceutical industry for assessing aerodyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed046ba6687b0e11a69be5b962f827d
https://doi.org/10.1208/s12249-013-9984-7

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Evaluation of Abbreviated Impactor Measurements (AIM) and Efficient Data Analysis (EDA) for Dry Powder Inhalers (DPIs) Against the Full-Resolution Next Generation Impactor (NGI)

Autor: Sau L. Lee, Changning Guo, William H. Doub, Megha Mohan, S. Prasad Peri

Publikováno v: AAPS PharmSciTech. 18(5)

The full-resolution next generation impactor (NGI) and three abbreviated impactor systems were used to obtain the apparent aerodynamic particle size distribution (APSD) and other quality measures for marketed dry powder inhalers (DPIs) using the comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8a385d5d866e2b6d4c452d577629d6
https://pubmed.ncbi.nlm.nih.gov/27624069

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Evaluation of metered dose inhaler spray velocities using Phase Doppler Anemometry (PDA)

Autor: William H. Doub, Changning Guo, Xiaofei Liu

Publikováno v: International Journal of Pharmaceutics. 423:235-239

Droplet velocity is an important parameter which can significantly influence inhalation drug delivery performance. Together with the droplet size, this parameter determines the efficiency of the deposition of MDI products at different sites within th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f78e950f416e6ef6cb75085677313e6
https://doi.org/10.1016/j.ijpharm.2011.12.006

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Evaluating elevated release liner adhesion of a transdermal drug delivery system (TDDS): A study of Daytrana™ methylphenidate transdermal system

Autor: William H. Doub, Meiyu Shen, Lucinda F. Buhse, Stella G. Machado, Anna M. Wokovich

Publikováno v: Drug Development and Industrial Pharmacy. 37:1217-1224

Complaints from healthcare providers that the adhesive on the Daytrana™ methylphenidate transdermal drug delivery system (TDDS) adhered to the release liner to such an extent that the release liner could not be removed prompted this study. Daytrana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8d72bad42a282c2303c638fd20e305
https://doi.org/10.3109/03639045.2011.565773

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Effects of Vessel Geometric Irregularity on Dissolution Test Results

Autor: Lucinda F. Buhse, William H. Doub, Zongming Gao, Shafiq Ahadi, Benjamin J. Westenberger, Terry W. Moore

Publikováno v: Journal of Pharmaceutical Sciences. 100:1093-1101

Dissolution testing of pharmaceutical products is an important technique used extensively for both product development and quality control, but there are many variables that can affect dissolution results. In this study, the effect of the inner shape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f646ab8ae854be31d0d876509258eb
https://doi.org/10.1002/jps.22319

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The state of nano-sized titanium dioxide (TiO2) may affect sunscreen performance

Autor: Nakissa Sadrieh, Dianne E. Godar, Katherine M. Tyner, Anna M. Wokovich, William H. Doub

Publikováno v: International Journal of Cosmetic Science. 33:234-244

Synopsis In the past several years, there has been a trend in the sunscreen/cosmetics industry to replace micron-sized titanium dioxide (TiO2) particles with nanoscale materials. The increased use of nanoscale TiO2 has resulted in questions about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a68b493f6982c88a04e30a18cd4f945e
https://doi.org/10.1111/j.1468-2494.2010.00622.x

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