Výsledky vyhledávání - "William H. Daughaday"

William H. Daughaday and the foundations of modern research into growth hormone and the insulin-like growth factors

Autor: William H, Daughaday

Publikováno v: Pediatric endocrinology reviews : PER. 10(3)

This vignette summarizes some of the scientific accomplishments of Dr. William H. Daughaday, a founder of modern research into the biological effects of growth hormone and the insulin-like growth factors, and formulator of the somatomedin hypothesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09c4482f8fe3ecff2710eb06b6e4c496
https://pubmed.ncbi.nlm.nih.gov/23724435

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Free Insulin-Like Growth Factor (IGF) in Disorders of IGF Binding Protein 3 Complex Formation

Autor: William H. Daughaday

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 89:3-5

The concentration of free IGF-I and -II in normal human serum is less than 0.5% of the total concentration of the IGF (1). Despite the fact that this component is critical in the feedback regulation of pituitary GH secretion and is important in the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df1bc47d6d5d18cf8595bf0335c4dec
https://doi.org/10.1210/jc.2003-030882

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Secretion of a Large Molecular-Weight Form of Insulin-Like Growth Factor by a Primary Renal Tumor

Autor: Jack van Hoff, Patrick J. Buckley, William H. Daughaday, Elizabeth A. Korn, Thomas O. Carpenter

Publikováno v: Medical and Pediatric Oncology. 24:392-396

A 5-year-old boy with an abdominal mass was found to have a primary renal tumor of poorly identifiable histology. Prior to resection of the tumor, the patient exhibited several episodes of biochemical hypoglycemia. The hypoglycemia did not recur afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d10f5faff9a86218ce5f21cd7cd1d02
https://doi.org/10.1002/mpo.2950240610

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Abnormal serum IGF-II transport in non-islet cell tumor hypoglycemia results from abnormalities of both IGF binding protein-3 and acid labile subunit and leads to elevation of serum free IGF-II

Autor: Bakula Trivedi, Robert C. Baxter, William H. Daughaday

Publikováno v: Endocrine. 3:425-428

The syndrome of non-islet cell tumor hypoglycemia (NICTH) is the result of hypersecretion of IGF-II by a tumor although serum IGF-II is seldom elevated. This is attributable to abnormalities of the IGF binding proteins (IGFBPs) present in NICTH which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53b77ddc09a1c30e72728c52500b466
https://doi.org/10.1007/bf02935648

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Serum 'big insulin-like growth factor II' from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing

Autor: William H. Daughaday, Bakula Trivedi, Robert C. Baxter

Publikováno v: Proceedings of the National Academy of Sciences. 90:5823-5827

The insulin-like growth factor II (IGF-II) gene is overexpressed in many mesenchymal tumors and can lead to non-islet-cell tumor hypoglycemia (NICTH). ProIGF-II consists of the 67 aa of IGF-II with a carboxyl 89-aa extension, the E domain. A derivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a34ee57fcce4db741ffb562335cccc
https://doi.org/10.1073/pnas.90.12.5823

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Pituitary Gigantism

Autor: William H. Daughaday

Publikováno v: Endocrinology and Metabolism Clinics of North America. 21:633-647

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6f9609b0461c612e39134b3065fbe87
https://doi.org/10.1016/s0889-8529(18)30206-8

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Heterogeneity of serum peptides with immunoactivity detected by a radioimmunoassay for proinsulin-like growth factor-II E domain: description of a free E domain peptide in serum

Autor: Bakula Trivedi, William H. Daughaday

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 75:641-645

We have reported that normal human sera contain immunoactivity (IA) detected by a RIA directed against the first 21 amino acids of the E domain of proinsulin-like growth factor-II (pro-IGF-II). Marked elevations of E-21 IA were found in the serum of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b840ca1f1a62e8332574124fb03d8395
https://doi.org/10.1210/jcem.75.2.1379260

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Impaired Formation of the Ternary Insulin-Like Growth Factor-Binding Protein Complex in Patients with Hypoglycemia due to Nonislet Cell Tumors*

Autor: Robert C. Baxter, William H. Daughaday

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 73:696-702

In some subjects with hypoglycemia associated with tumors of mesenchymal origin, high insulin-like growth factor-II (IGF-II) levels have been described in serum and in the tumors. Tumor IGF-II of 10-15 kDa circulates in a 60-kDa complex, in contrast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3e94dc1b4998e00fb9f9d91e3b0585
https://doi.org/10.1210/jcem-73-4-696

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Tumor Secretion of Growth Factors

Autor: Thomas F. Deuel, William H. Daughaday

Publikováno v: Endocrinology and Metabolism Clinics of North America. 20:539-563

An increasing number of polypeptide growth factors have been identified that regulate not only cell proliferation but also an extraordinary range of cell activities, including matrix protein deposition and resolution, the maintenance of cell viabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59a0362b5f1716737287d13459efc993
https://doi.org/10.1016/s0889-8529(18)30258-5

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