Zobrazeno 1 - 10
of 20
pro vyhledávání: '"William H. Conrad"'
Autor:
Laurel Robbins, Ariane Balaram, Stefanie Dejneka, Matthew McMahon, Zarina Najibi, Peter Pawlowicz, William H. Conrad
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Tuberculosis (TB) is the second leading cause of death by a single infectious disease behind COVID-19. Despite a century of effort, the current TB vaccine does not effectively prevent pulmonary TB, promote herd immunity, or prevent transmiss
Externí odkaz:
https://doaj.org/article/ccf9446f62bd4ad7985f79c1790b1ce4
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Accurate epidemiological models are necessary for governments, organizations, and individuals to respond appropriately to the ongoing novel coronavirus pandemic. One informative metric epidemiological models provide is the basic reproduction
Externí odkaz:
https://doaj.org/article/a57b058191704a5bb9a665f38fc0c41e
Publikováno v:
Microbiol Mol Biol Rev
SUMMARY Pathogenic mycobacteria cause chronic and acute diseases ranging from human tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute and chronic human tuberculosis. Environmentally acquired nontubercular myc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cff19b70d444a708112afb1bdb222c
https://europepmc.org/articles/PMC8570393/
https://europepmc.org/articles/PMC8570393/
Autor:
Sarah H Louie, Xiao Yong Yang, William H Conrad, Jeanot Muster, Stephane Angers, Randall T Moon, Benjamin N R Cheyette
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4310 (2009)
BACKGROUND:Wnts are evolutionarily conserved ligands that signal through beta-catenin-dependent and beta-catenin-independent pathways to regulate cell fate, proliferation, polarity, and movements during vertebrate development. Dishevelled (Dsh/Dvl) i
Externí odkaz:
https://doaj.org/article/2593db82ff654bc598c9bb085787ca73
Autor:
William H. Conrad, Mark Troll, Malte L Pinckert, Lalita Ramakrishnan, Morwan M. Osman, Sew Y. Peak-Chew
The type VII secretion system ESX-1 mediates virulence in Mycobacterium tuberculosis and Mycobacterium marinum. We find that in M. marinum, the synthetic organoselenium compound ebselen inhibits secretion of ESAT-6, a major ESX-1 substrate. We find t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae66ee0574dd4d9268db31bf901c1f2
https://doi.org/10.1101/828574
https://doi.org/10.1101/828574
Autor:
William H. Conrad, Samuel J. L. Gascoigne, Ariane Balaram, Ayesha Quraishi, Said Omer Sadat, Brett Palmero, Christina Gimondo, Anna Sandler, Jonathan Anderson, Alejandro Rodriguez, Yoan Ganev
Publikováno v:
F1000Research. 9:886
Background:Gene silencing by CpG island hypermethylation often plays a role in colorectal cancer (CRC) progression. Certain regions of the genome, called high confidence differentially-methylated regions (DMRs), are consistently hypermethylated acros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbdfba1161bb32a915cf1fbfefe6af3
https://doi.org/10.12688/f1000research.20442.1
https://doi.org/10.12688/f1000research.20442.1
Autor:
William H. Conrad
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d12e37c1c487f00bd79178f4d4f7048
https://doi.org/10.1096/fasebj.2020.34.s1.02167
https://doi.org/10.1096/fasebj.2020.34.s1.02167
Autor:
Jonathan K. Shanahan, William H. Conrad, Roland Brosch, Frances Chu, Kevin K. Takaki, Lalita Ramakrishnan, Digby Hopkinson-Woolley, Morwan M. Osman, James Cameron
Mycobacterium tuberculosis and Mycobacterium marinum are thought to exert virulence, in part, through their ability to lyse host cell membranes. The type VII secretion system ESX-1 [6-kDa early secretory antigenic target (ESAT-6) secretion system 1]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cc1286ae97caa1a3f82ca94a7f7b1b
https://europepmc.org/articles/PMC5307465/
https://europepmc.org/articles/PMC5307465/
Autor:
William H. Conrad, Randall T. Moon, Rima M. Kulikauskas, Travis L. Biechele, Andy J. Chien, Reyna D. Swift
Publikováno v:
Cell Cycle. 11:3724-3730
The limitations of revolutionary new mutation-specific inhibitors of BRAF(V600E) include the universal recurrence seen in melanoma patients treated with this novel class of drugs. Recently, our lab showed that simultaneous activation of the Wnt/β-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005f4883afe64104a859cb12f926f20e
https://doi.org/10.4161/cc.21645
https://doi.org/10.4161/cc.21645
Publikováno v:
Journal of Investigative Dermatology. 129(7):1614-1627
It has been two decades since investigators discovered the link between the Drosophila wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of signaling proteins known as Wnts. Since the inception of the Wnt signaling fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72d5c2d635fde8e367559ce0bfef55e