Zobrazeno 1 - 6
of 6
pro vyhledávání: '"William H. Connors"'
Autor:
Yong Zhang, Ming Lei, Shana L. Posy, Kyoung S. Kim, Benjamin A. Seigal, Joseph Fargnoli, Stuart Emanuel, Percy H. Carter, Nicholas K. Terrett, Neha Surti, Robert M. Borzilleri, Henry Shen, Joseph G. Naglich, Matthew Pokross, Randy Talbott, Andrew Fraley, William H. Connors
Publikováno v:
Journal of Medicinal Chemistry. 58:2855-2861
Affinity selection screening of macrocycle libraries derived from DNA-programmed chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic caspases. X-ray cocrystal structures of key compounds with XIAP BIR2 suggeste
Publikováno v:
Organic Letters. 5:247-250
[reaction: see text] A method is presented for the synthesis of single compounds or small combinatorial libraries of oligonucleotides with 2'-acylamido-2'-deoxyuridine residues at the 3'-terminus. Selection experiments identified the residue of anthr
Publikováno v:
Journal of the American Chemical Society. 124:4236-4246
Quinolones are gyrase inhibitors that are widely used as antibiotics in the clinic. When covalently attached to oligonucleotides as 5'-acylamido substituents, quinolones were found to stabilize duplexes of oligonucleotides against thermal denaturatio
Autor:
William H. Connors, and Andriy A. Mokhir, Clemens Richert, Olga P. Kryatova, Colleen F. Bleczinski
Publikováno v:
Organic Letters. 3:987-990
[structure: see text]. Reported here is the synthesis of oligonucleotides containing a 2'-acylamido-2'-deoxyuridine residue at their 3'-terminus. Compared to control sequences bearing a thymidine residue, the quinolone-capped duplexes give higher UV
Autor:
Sukunath Narayanan, Clemens Richert, Shruti Maheshwary, William H. Connors, Karsten Siegmund, Michael Printz, Matthias Riedrich
Publikováno v:
Nucleic Acids Research
Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone. We solved the 3D structu
Publikováno v:
Nucleic acids research. 29(17)
A total of 16 oligodeoxyribonucleotides of general sequence 5′-TCTTCTZTCTTTCT-3′, where Z denotes an N-acyl-N-(2-hydroxyethyl)glycine residue, were prepared via solid phase synthesis. The ability of these oligonucleotides to form triplexes with t