Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

Autor: Giuseppe Montalto, Linda S. Steelman, Alberto M. Martelli, Lucio Cocco, James A. McCubrey, Saverio Candido, Ferdinando Nicoletti, Massimo Libra, Melchiorre Cervello, Shaw M. Akula, Stephen L. Abrams, William H. Chappell, Stefano Ratti

Publikováno v: Aging (Albany, N.Y. Online) 12 (2020): 10194–10210. doi:10.18632/aging.103377
info:cnr-pdr/source/autori:Chappell WH; Candido S; Abrams SL; Akula SM; Steelman LS; Martelli AM; Ratti S; Cocco L; Cervello M; Montalto G; Nicoletti F; Libra M; McCubrey JA;/titolo:Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf%2FMEK%2FERK and PI3K%2FAkt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines/doi:10.18632%2Faging.103377/rivista:Aging (Albany, N.Y. Online)/anno:2020/pagina_da:10194/pagina_a:10210/intervallo_pagine:10194–10210/volume:12
Aging (Albany NY)

Background TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is very important in aging. The molecular structure and biochemical properties of collagen changes during aging. The discoidin domain receptor (DDR1) is regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1d22962758c7a132d3c12cb5324a1b
https://publications.cnr.it/doc/425339

Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells

Autor: Agnieszka Gizak, Alberto M. Martelli, Linda S. Steelman, James A. McCubrey, David M. Terrian, Timothy L. Fitzgerald, Lucio Cocco, Dariusz Rakus, Stephen L. Abrams, William H. Chappell, Kvin Lertpiriyapong

Publikováno v: Advances in Biological Regulation. 60:64-87

Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon will be the second leading cause of cancer death in the USA. This is a deadly malignancy with an incidence that approximates the mortality with 44,000 n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205c779978d1ead40d3806d96d9a22ad
https://doi.org/10.1016/j.jbior.2015.10.001

Novel approaches to target cancer initiating cells–Eliminating the root of the cancer

Autor: James A. McCubrey, Kazuo Umezawa, Linda S. Steelman, Stephen L. Abrams, William H. Chappell, Lucio Cocco, Richard A. Franklin, Alberto M. Martelli

Publikováno v: Advances in Biological Regulation. 52:249-264

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb5121976f22a0ec6556edf031b4653
https://doi.org/10.1016/j.advenzreg.2011.09.011

Homologous Recombination Repair Factors Rad51 and BRCA1 Are Necessary for Productive Replication of Human Papillomavirus 31

Autor: William H. Chappell, Daniel C. Anacker, Dipendra Gautam, Bryan A. Johnson, Cary A. Moody, Suzan T. Ok

High-risk human papillomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage response (DDR), which is necessary for productive viral replication. In response to DNA double-strand breaks (DSBs), ATM activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5305eaed93a75388fe50cb3f41a2b816
https://europepmc.org/articles/PMC4810724/

Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy

Autor: Antonio Bonati, Stephen L. Abrams, William H. Chappell, Piotr Laidler, Danijela Maksimović-Ivanić, Linda S. Steelman, Francac Stivala, Giuseppeo Montalto, Sanja Mijatović, Giovanni Ligresti, Negin Misaghian, Massimo Libra, James A. McCubrey, Alberto M. Martelli, Ferdinando Nicoletti, Jörg Bäsecke, Lucio Cocco, Camilla Evangelisti, Melchiorre Cervello

Publikováno v: Current Pharmaceutical Design. 18:1784-1795

An area of therapeutic interest in cancer biology and treatment is targeting the cancer stem cell, more appropriately referred to as the cancer initiating cell (CIC). CICs comprise a subset of hierarchically organized, rare cancer cells with the abil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d358d54125a8aac8294e0d5457f6c40
https://doi.org/10.2174/138161212799859701