Zobrazeno 1 - 10
of 28
pro vyhledávání: '"William H. Brissette"'
Autor:
Donald M. Engelman, Paul D. Lira, Erin E. Matthews, Damien Thévenin, Lisa Gotow, Lawrence A. Reiter, William H. Brissette, Julia M. Rogers
Publikováno v:
The FASEB Journal. 25:2234-2244
We report how rotational variations in transmembrane (TM) helix interactions participate in the activity states of the thrombopoietin receptor (TpoR), a type 1 cytokine receptor that controls the production of blood platelets. We also explore the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd91de1aeee848c79722efd13066a43
https://doi.org/10.1096/fj.10-178673
https://doi.org/10.1096/fj.10-178673
Autor:
Brett M. Lillie, Matthew Frank Brown, Bret D. Perry, Mark Edward Flanagan, Chakrapani Subramanyam, Kudlacz Elizabeth M, Jianmin Sun, Michael B. Fisher, Todd Andrew Blumenkopf, Chang Shang-Poa, Perry S. Sawyer, Timothy J. Strelevitz, Sandra P. McCurdy, William H. Brissette, Craig R. Kent, Paul S. Changelian, Jonathan L. Doty, Michael John Munchhof, David A Whipple, Jeffrey M. Casavant, Michael Hines, Kelly S. Magnuson, Eileen A. Elliott
Publikováno v:
Journal of Medicinal Chemistry. 53:8468-8484
There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells and are involved in the signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8b2178a892e219d40a9e1abea75681
https://doi.org/10.1021/jm1004286
https://doi.org/10.1021/jm1004286
Autor:
James P. Driscoll, Eric B. McElroy, Christopher S. Jones, Matthew Frank Brown, Jonathan L. Doty, William H. Brissette, Sharon L. Ripp, Mark J. Mitton-Fry, Marc I. Smeets, Thomas M. Harris, Kristen A. Trevena, Amy S. Antipas, Jeffrey M. Casavant, Laura Cook Blumberg, David A. Reim, Lawrence A. Reiter, Michael John Munchhof, Sandra P. McCurdy, Andrei Shavnya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4069-4072
5-F substitution of an aminothiazole moiety within a series of thrombopoietin receptor agonists leads to potent agents with an improved hepatic safety profile in rodent toxicology studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9b330b187dd9637115bb616439c324
https://doi.org/10.1016/j.bmcl.2010.05.087
https://doi.org/10.1016/j.bmcl.2010.05.087
Autor:
David G. Perregaux, Timothy Scott Fisher, William H. Brissette, Paul D. Lira, Jeffrey L. Stock, Baiyong Li, Terence R.S. Ozolinš
Publikováno v:
Biochemical and Biophysical Research Communications. 388:683-688
HIF (hypoxia-inducible factor) hydroxylases have been implicated in EPO (erythropoietin) production and erythropoiesis. Here we examined the role of each of the three EGLN family members and the HIF asparaginyl hydroxylase FIH (factor inhibiting HIF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e7dc526cd118614f1f3d5562f017f3
https://doi.org/10.1016/j.bbrc.2009.08.058
https://doi.org/10.1016/j.bbrc.2009.08.058
Autor:
James H. Roache, Eric B. McElroy, Timothy Joseph Paradis, Aikomari Guzman-Martinez, Sara A. Burrell, Robert S. Foti, Matthew Frank Brown, Greg D. Lundquist, Kevin B. Bahnck, James P. Driscoll, Andrei Shavnya, Laurie Tylaska, Ronald P. Gladue, Michael B. Fisher, Poss Christopher Stanley, Molly A. McGlynn, William H. Brissette, Yi Lu, Brett M. Lillie, Laura Cook Blumberg, Flavia Fedeles, Matthew Merrill Hayward, Richard M. Shepard, Kristen A. Trevena, Paul D. Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3109-3112
The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7092f68daaded6a7d772a046b3e18482
https://doi.org/10.1016/j.bmcl.2007.03.037
https://doi.org/10.1016/j.bmcl.2007.03.037
Autor:
Michael J Larson, Bruce A. Reitz, Sally Zhang, Bari Holm, Douglas A. Ball, Ricardo T. Paniagua, Geraldine Rousvoal, Dominic C. Borie, Macy Lau, John P. Higgins, Ming-Sing Si, Paul S. Changelian, Jennifer Hawkins, Randall E. Morris, Eileen A. Elliott, Mona G. Flores, Andrew Campbell, William H. Brissette, Kudlacz Elizabeth M
Publikováno v:
Transplantation. 79:791-801
BACKGROUND Janus kinase 3 (JAK3) mediates signal transduction from cytokine receptors using the common chain (gammac). Because mutations in genes encoding gammac or JAK3 result in immunodeficiency, we investigated the potential of a rationally design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57f5b07ae97fda11512567ef1f64fe5
https://doi.org/10.1097/01.tp.0000157117.30290.6f
https://doi.org/10.1097/01.tp.0000157117.30290.6f
Autor:
Matthew Frank Brown, William H. Brissette, Amy P DiRico, Eric B. McElroy, Ronald P. Gladue, Timothy Joseph Paradis, Laurie Tylaska, Maryrose J. Conklyn, Deye Zheng, Erin N Mairs, John Charles Kath, Poss Christopher Stanley, Molly A. McGlynn, Dorff Peter H, William H. Martin, Brett M. Lillie, Ingrid A. Stock, Paul D. Lira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2169-2173
The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef990508ecff58522de63097d9a8e3d
https://doi.org/10.1016/j.bmcl.2004.02.021
https://doi.org/10.1016/j.bmcl.2004.02.021
Autor:
Deborah Finco-Kent, Panayiotis Zagouras, James F. Smith, Kwansik Yoon, Douglas A. Fisher, Randall E. Morris, Jeffrey M. Casavant, Eileen A. Elliott, Dominic C. Borie, William H. Martin, Craig R. Kent, Paul S. Changelian, Linda F. Nelms, John J. O'Shea, Bonnie J. Rizzuti, Anthony J. Milici, Sandra P. McCurdy, Bret D. Perry, Todd Andrew Blumenkopf, Michael John Munchhof, John P. Higgins, Ming-Sing Si, Michael J Larson, William H. Brissette, Chakrapani Subramanyam, Thasia G. Woodworth, Timothy J. Strelevitz, John L. Doty, Bari Holm, Mark Edward Flanagan, Mary Josephine Saltarelli, Gretchen E Beckius, Chunyan Su, Ricardo T. Paniagua, Michael Hines, Chan R. Beals, Johnson Kimberly Sue, Maryrose J. Conklyn, Bruce H. Littman, Kelly S. Magnuson, Holly A. Magna, Perry S. Sawyer, Bruce A. Reitz, Brett M. Lillie, Lisa S. Hayes, Kudlacz Elizabeth M, David A. Whipple, James D. Moyer, Erika R. Koslov, Jianmin Sun, Matthew Frank Brown, Anderson See Gaweco, Yong Jie Zhou, Chang Shang-Poa, Deanna L. Baker, Thomas T. Kawabata, Shelley G. des Etages, Michael B. Fisher, Douglas J. Ball
Publikováno v:
Science. 302:875-878
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea15b17ccaadc6b33998089ee820ac1d
https://doi.org/10.1126/science.1087061
https://doi.org/10.1126/science.1087061
Autor:
Mary M. Payette, Laurent P. Audoly, Joan R. Wicks, William H. Brissette, Sandra P. McCurdy, Christopher A. Gabel, Carol Donovan, Nina Petrushova, Jeffrey M. Labasi, Paul D. Lira
Publikováno v:
The Journal of Immunology. 168:6436-6445
When challenged with extracellular ATP, leukocytes respond and activate processes attributed to the P2X7 receptor (P2X7R), an unusual ligand-gated ion channel. To prove P2X7R involvement, blood samples from P2X7R-deficient mice were characterized. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eddf8293d627fc6d39ff314af7b7c8d
https://doi.org/10.4049/jimmunol.168.12.6436
https://doi.org/10.4049/jimmunol.168.12.6436
Autor:
Karen Honey, Peter Cresswell, Courtney Beers, Eileen A. Elliott, Alexander Y. Rudensky, Meghan E. Duff, Christoph Peters, William H. Brissette, Maja Maric
Publikováno v:
Journal of Biological Chemistry. 276:22573-22578
Loading of antigenic peptide fragments on major histocompatibility complex class II molecules is essential for generation of CD4(+) T cell responses and occurs after cathepsin-mediated degradation of the invariant chain chaperone molecule. Cathepsins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8028cc7d04beb70e65b6c02b8b3172
https://doi.org/10.1074/jbc.m101851200
https://doi.org/10.1074/jbc.m101851200