Zobrazeno 1 - 10
of 43
pro vyhledávání: '"William H. Baricos"'
Publikováno v:
Experimental Biology and Medicine. 228:1018-1022
Decreased degradation of the glomerular extracellular matrix (ECM) is thought to contribute to the accumulation of glomerular ECM that occurs in diabetic nephropathy and other chronic renal diseases. Several lines of evidence indicate a key role for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9497acb0252ba134b7eb09585a56f44
https://doi.org/10.1177/153537020322800905
https://doi.org/10.1177/153537020322800905
Autor:
William H. Baricos
Publikováno v:
Current Opinion in Nephrology and Hypertension. 4:365-368
Recent evidence suggests that decreased degradation of the glomerular extracellular matrix may contribute to the matrix accumulation that occurs in the progression of chronic renal disease. The presence of matrix metalloproteinases in cultured glomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::037a2b97623858691b06b9c8c5cd1279
https://doi.org/10.1097/00041552-199507000-00014
https://doi.org/10.1097/00041552-199507000-00014
Autor:
Maria F.K.L. Leung, Wai-Choi Leung, Arlene Lefebre, William H. Baricos, Suzanne Meleg Smith, Robert J. Leaber
Publikováno v:
Alcohol. 10:477-480
Using the intragastric ethanol infusion model of IgA nephropathy, we investigated the hypothesis that in this model mesangial changes commence prior to the deposition of IgA. We studied the two cellular components of the glomerular mesangium: the mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f528c29644a9e3547b1defb28a84ea
https://doi.org/10.1016/0741-8329(93)90068-y
https://doi.org/10.1016/0741-8329(93)90068-y
Autor:
Quoc C. Le, Li-Teh Wu, William H. Baricos, Sudhir V. Shah, Kazunori Hanada, Elliott Shaw, Shirley L. Cortez
Publikováno v:
Archives of Biochemistry and Biophysics. 288:468-472
We have utilized specific, irreversible inhibitors of cysteine proteinases to examine the role of renal cathepsin B and cathepsin L in the proteinuria which occurs in an experimental model of human glomerular disease. Administration of trans-epoxysuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4108a51b7179f5d6369b7f2259cd4d6
https://doi.org/10.1016/0003-9861(91)90222-5
https://doi.org/10.1016/0003-9861(91)90222-5
Autor:
William H. Baricos, Sudhir V. Shah
Publikováno v:
Kidney International. 40(2):161-173
Despite significant advances in our understanding of the pathogenesis of glomerular injury, the specific mechanisms responsible for the pathological changes in glomerular structure and function which occur in glomerular disease remain poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74f3664409856d81bf9892c4b4b8516
Publikováno v:
American Journal of Physiology-Renal Physiology. 260:F555-F561
We have utilized [3H] gelatin to document high activity of a metalloproteinase present in freshly isolated rat glomeruli. [3H] gelatin degradation by glomeruli was markedly inhibited by EDTA (10 mM: -89 +/- 2.3%) and o-phenanthroline (2 mM: -72 +/- 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589b235e2a6668b85d6d615e4041dbef
https://doi.org/10.1152/ajprenal.1991.260.4.f555
https://doi.org/10.1152/ajprenal.1991.260.4.f555
Autor:
Youwen Zhou, Quoc C. Le, Sudhir V. Shah, Sally O'Connor, Rudene M. Dicarlo, Shirley L. Cortez, William H. Baricos
Publikováno v:
Kidney International. 38:395-401
Glomerular basement membrane degradation by endogenous cysteine proteinases in isolated rat glomeruli. Recent in vitro and in vivo studies suggest that cysteine proteinases may play an important role in degradation of the glomerular basement membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407bdd6047daa949d9332e8c1566cf20
https://doi.org/10.1038/ki.1990.218
https://doi.org/10.1038/ki.1990.218
Autor:
Sumana Ghosh, Tanya Jackson, Linda E. Hyman, Jennifer McGee, Anna M. Boguszewska Chachulska, William H. Baricos, Edward Kwon
Publikováno v:
The Journal of biological chemistry. 277(18)
Elongin C is a highly conserved, low molecular weight protein found in a variety of multiprotein complexes in human, rat, fly, worm, and yeast cells. Among the best characterized of these complexes is a mammalian E3 ligase that targets proteins for u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e519a7eccefff3ae3e1c69765b7ca6ac
https://pubmed.ncbi.nlm.nih.gov/11864988
https://pubmed.ncbi.nlm.nih.gov/11864988
Publikováno v:
Journal of the American Society of Nephrology : JASN. 11(4)
The complex interactions of glomerular and tubular epithelial cells with the basal laminae play a critical role in renal function. Disruption of these interactions has been widely implicated in glomerular diseases and acute renal failure. MDC are a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c33a74f758f79526f5db19fefde683
https://pubmed.ncbi.nlm.nih.gov/10752518
https://pubmed.ncbi.nlm.nih.gov/10752518
Publikováno v:
Journal of the American Society of Nephrology : JASN. 10(4)
Accumulation of the glomerular extracellular matrix (ECM) is a pivotal event in the progression from acute glomerular injury to end-stage renal disease. Although enhanced ECM synthesis has been demonstrated to contribute to ECM accumulation, the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6616f5719583ef4265017b4f9fb48758
https://pubmed.ncbi.nlm.nih.gov/10203363
https://pubmed.ncbi.nlm.nih.gov/10203363