Zobrazeno 1 - 10
of 171
pro vyhledávání: '"William H Peranteau"'
Autor:
Marcus G Davey, John S Riley, Abigail Andrews, Alec Tyminski, Maria Limberis, Jennifer E Pogoriler, Emily Partridge, Aliza Olive, Holly L Hedrick, Alan W Flake, William H Peranteau
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0171132 (2017)
A major limitation to adeno-associated virus (AAV) gene therapy is the generation of host immune responses to viral vector antigens and the transgene product. The ability to induce immune tolerance to foreign protein has the potential to overcome thi
Externí odkaz:
https://doaj.org/article/7d8d3bc09de7417bac527a2a41c0696c
Autor:
Dominique L. Brooks, Manuel J. Carrasco, Ping Qu, William H. Peranteau, Rebecca C. Ahrens-Nicklas, Kiran Musunuru, Mohamad-Gabriel Alameh, Xiao Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Phenylketonuria (PKU), an autosomal recessive disorder caused by pathogenic variants in the phenylalanine hydroxylase (PAH) gene, results in the accumulation of blood phenylalanine (Phe) to neurotoxic levels. Current dietary and medical trea
Externí odkaz:
https://doaj.org/article/a955591fbb65411b9f8d9923910aa8ee
Autor:
Sourav K. Bose, Brandon M. White, Meghana V. Kashyap, Apeksha Dave, Felix R. De Bie, Haiying Li, Kshitiz Singh, Pallavi Menon, Tiankun Wang, Shiva Teerdhala, Vishal Swaminathan, Heather A. Hartman, Sowmya Jayachandran, Prashant Chandrasekaran, Kiran Musunuru, Rajan Jain, David B. Frank, Philip Zoltick, William H. Peranteau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Lysosomal storage diseases like mucopolysaccharidosis type I (MPS I) cause pathology before birth and result in early morbidity and mortality. Here, the authors show that in utero base editing mediates multi-organ phenotypic and survival benefits in
Externí odkaz:
https://doaj.org/article/a932a6ec2ba7497281b8dba976e50d99
Autor:
Heron D. Baumgarten, Christina M. Wright, Avery C. Rossidis, Kendall M. Lawrence, Aimee G. Kim, Ali Y. Mejaddam, Patrick E. McGovern, Melissa N. Orr, Barbara E. Coons, Zoya Butt, Haiying Li, Grace Hwang, Antoneta Radu, Lauren J. Brown, Ronald C. Rubenstein, William H. Peranteau, Marcus Davey, Robert O. Heuckeroth, Alan W. Flake
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 623-637 (2020)
Background and Aims: The Extra-Uterine Environment for Neonatal Development (EXTEND) aims to avoid the complications of prematurity, such as NEC. Our goal was to determine if bowel development occurs normally in EXTEND-supported lambs, with specific
Externí odkaz:
https://doaj.org/article/3769f4f865ec4e579017f0679c426f4e
Publikováno v:
Current Opinion in Obstetrics & Gynecology. 35:134-139
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ee58878477e5549980b0ee2043c363c
https://doi.org/10.1097/gco.0000000000000854
https://doi.org/10.1097/gco.0000000000000854
Autor:
Apeksha Dave, Cara L. Berkowitz, Valerie L. Luks, Brandon M. White, Rohan Palanki, Marco D. Carpenter, John S. Riley, Sourav K. Bose, Haiying Li, Li Li, Pallavi V. Menon, Shiva Teerdhala, Mina Ebrahimi, Philip W. Zoltick, William H. Peranteau
Publikováno v:
Gene Therapy. 30:232-235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dffdfb23aca6e5160a4b3a4eb6667f5
https://doi.org/10.1038/s41434-023-00395-0
https://doi.org/10.1038/s41434-023-00395-0
Publikováno v:
American Journal of Surgical Pathology. 47:568-579
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f543d2ac68fa953f39b03edf981bc796
https://doi.org/10.1097/pas.0000000000002025
https://doi.org/10.1097/pas.0000000000002025
Publikováno v:
Clinics in Perinatology. 49:811-820
Significant advances in maternal-fetal medicine and gene sequencing technology have fostered a new frontier of in utero molecular and cellular therapeutics, including gene editing, enzyme replacement therapy, and stem cell transplantation to treat si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca2eba23c4f80bc76e3fb7bb0ea2a81
https://doi.org/10.1016/j.clp.2022.06.005
https://doi.org/10.1016/j.clp.2022.06.005
Autor:
Nya D. Nelson, Feng Xu, Prashant Chandrasekaran, Leslie A. Litzky, William H. Peranteau, David B. Frank, Marilyn Li, Jennifer Pogoriler
Publikováno v:
Modern Pathology. 35:1870-1881
The potential pathogenetic mechanisms underlying the varied morphology of congenital pulmonary airway malformations (CPAMs) have not been molecularly determined, but a subset have been shown to contain clusters of mucinous cells (MCC). These clusters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2288dcaa9e648b6c8fc4b74647476228
https://doi.org/10.1038/s41379-022-01129-0
https://doi.org/10.1038/s41379-022-01129-0
Autor:
Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland, Jiancheng Han, Alexander J. Schupper, James T. Connelly, Kevin C. Dysart, Jack Rychik, Holly L. Hedrick, William H. Peranteau, Alan W. Flake
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The ability to support the development of a premature fetus in the form of an extracorporeal system has had limited success. Here, the authors show that an extra-uterine device that mimics the intra-uterine environment can provide physiologic support
Externí odkaz:
https://doaj.org/article/45db932763ce4371b11c234c5b821457