In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis.

Autor: Tyler Godat, Nicolas P Cottaris, Sara Patterson, Kendall Kohout, Keith Parkins, Qiang Yang, Jennifer M Strazzeri, Juliette E McGregor, David H Brainard, William H Merigan, David R Williams

Publikováno v: PLoS ONE, Vol 17, Iss 11, p e0278261 (2022)

The primate fovea is specialized for high acuity chromatic vision, with the highest density of cone photoreceptors and a disproportionately large representation in visual cortex. The unique visual properties conferred by the fovea are conveyed to the

Externí odkaz: https://doaj.org/article/147f6bed29484ff985eccf7d5a12e602

All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice.

Autor: Soon Keen Cheong, Jennifer M Strazzeri, David R Williams, William H Merigan

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0194947 (2018)

Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of cellular function in the living eye, to study loss of vision in animal models of retinal disea

Externí odkaz: https://doaj.org/article/d4355daea34644b5a6afc17e9168ae62

Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation

Autor: Teresa Puthussery, Colin J Chu, David R. Williams, Peter J. Murphy, William H. Merigan, Tyler Godat, William S. Fischer, Zhengyang Xu, Brittany Bateman, Juliette E. McGregor, Karteek Kunala, Jennifer M. Strazzeri, Keith Parkins

Publikováno v: McGregor, J E, Kunala, K, Xu, Z, Murphy, P J, Godat, T, Strazzeri, J M, Bateman, B A, Fischer, W S, Parkins, K, Chu, C J, Puthussery, T, Williams, D R & Merigan, W H 2021, ' Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation ', Molecular Therapy . https://doi.org/10.1016/j.ymthe.2021.09.014

All retina-based vision restoration approaches rely on the assumption that photoreceptor loss does not preclude reactivation of the remaining retinal architecture. Whether extended periods of vision loss limit the efficacy of restorative therapies at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4e16318cda80a4f91042948e378052
https://pubmed.ncbi.nlm.nih.gov/34547460

Optogenetic restoration of retinal ganglion cell activity in the living primate

Autor: Kamal Dhakal, William H. Merigan, Tyler Godat, Juliette E. McGregor, Keith Parkins, Jennifer M. Strazzeri, Brittany Bateman, David R. Williams, William S. Fischer

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications

Optogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photoreceptors have degenerated and light sensitivity has been irreversibly lost. We combine adaptive optics ophthalmoscopy with cal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96deb6a30572f45b57b6cb42c13e0f38
https://doi.org/10.1038/s41467-020-15317-6

In vivo directed evolution of AAV in the primate retina

Autor: Cécile Fortuny, Timothy P Day, Leah C. Byrne, David V. Schaffer, Meike Visel, William H. Merigan, John G. Flannery, Deniz Dalkara

Efficient AAV-mediated gene delivery remains a significant obstacle to effective retinal gene therapies. Here, we apply directed evolution – guided by deep sequencing and followed by direct in vivo secondary selection of high-performing vectors wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bd616165b9d2e4f295167d6814bfb8
https://doi.org/10.1101/847459