Zobrazeno 1 - 10
of 214
pro vyhledávání: '"William H Klein"'
Autor:
Takae Kiyama, Ching-Kang Chen, Steven W Wang, Ping Pan, Zhenlin Ju, Jing Wang, Shinako Takada, William H Klein, Chai-An Mao
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2018)
Abstract Background Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer retina, photoreceptors are particularly vulnerable to mutations affecti
Externí odkaz:
https://doaj.org/article/86e23958dde9462c9e095325aaa44ae2
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16184 (2011)
Duchenne muscular dystrophy (DMD) is the most prevalent inherited childhood muscle disorder in humans. mdx mice exhibit a similar pathophysiology to the human disorder allowing for an in-depth investigation of DMD. Myogenin, a myogenic regulatory fac
Externí odkaz:
https://doaj.org/article/245e7530a30e40d581c2074084dce9cd
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13535 (2010)
Although skeletal muscle metabolism is a well-studied physiological process, little is known about how it is regulated at the transcriptional level. The myogenic transcription factor myogenin is required for skeletal muscle development during embryon
Externí odkaz:
https://doaj.org/article/4c4fc84be06247f0ab44395cfb04c1b4
Autor:
Monica P. Colaiácovo, Bruce A. Yankner, Joseph M. Zullo, David A. Bennett, William H. Klein, Derek Drake, Patrick O’Hern, Noah Davidsohn, Sameer C. Dhamne, Liviu Aron, Chai An Mao, George M. Church, Alexander Rotenberg
Publikováno v:
Nature
The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related
Autor:
William H. Klein, Allison Shay, Amir Mohsenin, Christopher M. Whitaker, Stephen L. Mills, Takae Kiyama, Chai An Mao, Ye Long, Tudor C. Badea, Stephen C. Massey, Jan Parker-Thornburg, Hongyu Wu, Ching-Kang Chen
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 900-915.e5 (2019)
Summary: In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional characteristics. RGCs arise from a common pool of retinal progenitor cells during embryoni
Publikováno v:
BioTechniques, Vol 27, Iss 1, Pp 154-163 (1999)
A lacZ transgene, expressed by the myogenin promoter, was introduced into the mouse hypoxanthine phosphoribosyltransferase (Hprt) locus by gene targeting in embryonic stem cells. Embryos between E10.5—E18.5 days were analyzed for expression of the
Externí odkaz:
https://doaj.org/article/dd9e4353de0442d5af06805e3e12b926
Publikováno v:
Development
Ret signaling promotes branching morphogenesis during kidney development, but the underlying cellular mechanisms remain unclear. While Ret-expressing progenitor cells proliferate at the ureteric bud tips, some of these cells exit the tips to generate
Autor:
Chai An Mao, William H. Klein, Takae Kiyama, Zhenlin Ju, Jing Wang, Ching-Kang Chen, Shinako Takada, Steven W. Wang, Ping Pan
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2018)
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2018)
Background Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer retina, photoreceptors are particularly vulnerable to mutations affecting mitoch
Autor:
Shaohong Cheng, Shunzhen Zhang, Rajiv Dixit, Jimmy de Melo, Carol Schuurmans, Qi Zhang, Jeffrey T. Wigle, David D. Eisenstat, Nadean L. Brown, Jamie Zagozewski, William H. Klein, Xiuqian Mu
Publikováno v:
Development.
Regulated retinal ganglion cell (RGC) differentiation and axonal guidance is required for a functional visual system. Homeodomain and basic helix-loop-helix transcription factors are required for retinogenesis, as well as patterning, differentiation
Publikováno v:
Developmental Neurobiology. 74:1123-1140
The bHLH transcription factor ATOH7 (Math5) is essential for establishing retinal ganglion cell (RGC) fate. However, Atoh7-expressing retinal progenitor cells (RPCs) can give rise to all retinal cell types, suggesting that other factors are involved