Zobrazeno 1 - 10
of 15
pro vyhledávání: '"William H H Reece"'
Autor:
Stephen John Clarke, Matthew Burge, Kynan Feeney, Peter Gibbs, Kristian Jones, Gavin Marx, Mark P Molloy, Timothy Price, William H H Reece, Eva Segelov, Niall C Tebbutt
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229900 (2020)
BackgroundIn spite of demonstrating prognostic and possibly predictive benefit in retrospective cohorts and meta-analyses of cancer populations, including colorectal cancer (CRC), prospective evaluation of the relationship between neutrophil to lymph
Externí odkaz:
https://doaj.org/article/cd2703a957b846b1ba3c1198c841daa4
Autor:
Margaret Pinder, Katie L. Flanagan, Edwin A. M. Lee, Adrian V. S. Hill, Gabriela Minigo, William H. H. Reece, Magdalena Plebanski, Robin L. Bailey
The leading blood-stage malaria vaccine candidate antigen, Plasmodium falciparum merozoite surface protein-1 (MSP-1) occurs in two major allelic types worldwide. The molecular basis promoting this stable dimorphism is unknown. In this study, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47271accb113746c16666f86ac49a4b
https://ora.ox.ac.uk/objects/uuid:9dcd44da-9b3e-45a3-b1a2-574868195a49
https://ora.ox.ac.uk/objects/uuid:9dcd44da-9b3e-45a3-b1a2-574868195a49
Autor:
Adrian V. S. Hill, Sarah C. Gilbert, Michael Roy, Kent E. Kester, Joerg Schneider, Tim E. A. Peto, Vasee S. Moorthy, Robert E. Sinden, Philip Gothard, Carolyn M. Hannan, Daniel P. Webster, Kate E. Watkins, Tom Blanchard, Katie L. Flanagan, Jenni M. Vuola, James F. Cummings, Susanna Dunachie, Karen Brown, William H. H. Reece, Nirmalan Arulanantham, D. Gray Heppner, G.A. Butcher, Geoffrey L. Smith, Simone Everaere, Ansar A. Pathan, M. Roberts, Jackie Williams, Samuel J. McConkey
Publikováno v:
Nature Medicine. 9:729-735
In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epiderm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b252daec25b9d2aa7e8950118f31276
https://doi.org/10.1038/nm881
https://doi.org/10.1038/nm881
Autor:
Joe Cohen, Keith P. W. J. McAdam, Tom Doherty, William H. H. Reece, Martine Delchambre, Kent E. Kester, Brian Greenwood, Ali Alloueche, Paul Milligan, David J. Conway, Laurence Vigneron, Gerald Voss, Lawrence Yamuah, Margaret Pinder, Nadia Tornieporth, W. Ripley Ballou, Philip Gothard, Kalifa Bojang, Adrian V. S. Hill
Publikováno v:
The Lancet. 358:1927-1934
Summary Background RTS,S/AS02 is a pre-erythrocytic malaria vaccine based on the circumsporozoite surface protein of Plasmodium falciparum fused to HBsAg, incorporating a new adjuvant (AS02). We did a randomised trial of the efficacy of RTS,S/AS02 ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c89b513c48983c84cdd7361e2195713
https://doi.org/10.1016/s0140-6736(01)06957-4
https://doi.org/10.1016/s0140-6736(01)06957-4
Autor:
K. P. M. J. Mcadam, Edwin A. M. Lee, Peter Akinwunmi, William H. H. Reece, Joe Cohen, A. V. S. Hill, Katie L. Flanagan, Paul Milligan, Nadia Tornieporth, Magdalena Plebanski, Tom Doherty, R. Ballou, Margaret Pinder, Assan Jaye
Publikováno v:
Clinical and experimental immunology. 135(2)
SUMMARY Vaccination of malaria-naive humans with recombinant RTS,S/AS02, which includes the C-terminus of the circumsporozoite protein (CS), has been shown to induce strong T cell responses to both the whole protein antigen and to peptides from CS. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99796dfcf0f681bf79441708e112baf
https://pubmed.ncbi.nlm.nih.gov/14738458
https://pubmed.ncbi.nlm.nih.gov/14738458
Autor:
Adrian V. S. Hill, Gerald Voss, Katherine R Watkins, Kalifa Bojang, Joe Cohen, Magdalena Plebanski, Ali Alloueche, William H. H. Reece, Paul Milligan, Kent E. Kester, Simone Everaere, Brian Greenwood, Philip Gothard, Nadia Tornieporth, Keith P. W. J. McAdam, Margaret Pinder, Peter Akinwunmi, Tom Doherty
Publikováno v:
Nature medicine. 10(4)
Many human T-cell responses specific for epitopes in Plasmodium falciparum have been described, but none has yet been shown to be predictive of protection against natural malaria infection. Here we report a peptide-specific T-cell assay that is stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f435ed1faca137aac820ede0d707afa
https://pubmed.ncbi.nlm.nih.gov/15034567
https://pubmed.ncbi.nlm.nih.gov/15034567
Autor:
Margaret Pinder, Sowsan Atabani, Joerg Schneider, Keith P. W. J. McAdam, William H. H. Reece, Kate E. Watkins, Carolyn M. Hannan, Adrian V. S. Hill, Sarah C. Gilbert, Kalifa Bojang, Vasee S. Moorthy
Publikováno v:
The Journal of infectious diseases. 188(8)
The present study is an investigation of the safety and immunogenicity of DNA and modified vaccinia virus Ankara (MVA) candidate vaccines, each encoding the malaria DNA sequence multiple epitope-thrombospondin related adhesion protein (ME-TRAP), agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3840c0cc13106419967b9ffa90cc7cc
http://ora.ox.ac.uk/objects/uuid:b1bdb594-0e75-4f7d-b190-6aebdc8f852f
http://ora.ox.ac.uk/objects/uuid:b1bdb594-0e75-4f7d-b190-6aebdc8f852f
Autor:
Katalin A. Wilkinson, Ajit Lalvani, Helen Ayles, Ann Chapman, Mwansa Munkanta, Katie J. Ewer, William H. H. Reece, Peter Godfrey-Faussett, Ansar A. Pathan, Alwyn Mwinga
Publikováno v:
AIDS (London, England). 16(17)
Objectives: An accurate test for Mycobacterium tuberculosis infection is urgently needed. The tuberculin skin test (TST) lacks sensitivity particularly in HIV-infected individuals and has poor specificity because of antigenic cross-reactivity with Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b87bf400f8ca0553690dc0a712eaa8a
https://pubmed.ncbi.nlm.nih.gov/12891078
https://pubmed.ncbi.nlm.nih.gov/12891078
Autor:
Margaret Pinder, Magdalena Plebanski, Katie L. Flanagan, A. V. S. Hill, Peter Akinwunmi, Mario Cortina-Borja, William H. H. Reece, Edwin A. M. Lee, Philip Gothard
T-cell responses directed against the circumsporozoite protein (CS) ofPlasmodium falciparumcan mediate protection against malaria. We determined the frequency of T cells reactive to different regions of the CS in the blood of donors naturally exposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b9dbd68091034462f210780b81b424
https://europepmc.org/articles/PMC127745/
https://europepmc.org/articles/PMC127745/
Autor:
Adrian V. S. Hill, David C. Kaslow, Edwin A. M. Lee, Urszula Krzych, Carter L. Diggs, W. Ripley Ballou, Kennedy Odhiambo, Dupeh R. Palmer, Vasso Apostolopoulos, Kevin Marsh, Katie L. Flanagan, William H. H. Reece, Magdalena Plebanski, Margaret Pinder, Mike B. Gravenor, Wendy A. Keitel, Kent E. Kester
Plasmodium falciparummalaria is a major cause of death in the tropics. The 19-kDa subunit ofP. falciparummerozoite surface protein 1 (MSP-119), a major blood stage vaccine candidate, is the target of cellular and humoral immune responses in animals a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d738d65aa1124ea31f326dc23dd6418
https://cronfa.swan.ac.uk/Record/cronfa19486
https://cronfa.swan.ac.uk/Record/cronfa19486