Zobrazeno 1 - 10
of 25
pro vyhledávání: '"William H Aisenberg"'
Autor:
Brett A. McCray, Erika Diehl, Jeremy M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander R. Lau, Dominick J. Rich, Benedikt Goretzki, Ute A. Hellmich, Thomas E. Lloyd, Charlotte J. Sumner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of ne
Externí odkaz:
https://doaj.org/article/c12c32fb25af4c0fbec8907050b017a1
Autor:
Laura K. Aisenberg, Kimberly E. Rousseau, Katherine Cascino, Guido Massaccesi, William H. Aisenberg, Wensheng Luo, Kar Muthumani, David B. Weiner, Stephen S. Whitehead, Michael A. Chattergoon, Anna P. Durbin, Andrea L. Cox
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
The Aedes aegypti mosquito transmits both dengue virus (DENV) and Zika virus (ZIKV) . Individuals in endemic areas are at risk for infection with both viruses, as well as for repeated DENV infection. In the presence of anti-DENV antibodies, outcomes
Externí odkaz:
https://doaj.org/article/b518d8789686457aafe5b023c2ac3a9d
Autor:
Brian M. Woolums, Brett A. McCray, Hyun Sung, Masashi Tabuchi, Jeremy M. Sullivan, Kendra Takle Ruppell, Yunpeng Yang, Catherine Mamah, William H. Aisenberg, Pamela C. Saavedra-Rivera, Bryan S. Larin, Alexander R. Lau, Douglas N. Robinson, Yang Xiang, Mark N. Wu, Charlotte J. Sumner, Thomas E. Lloyd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Mutations in the TRPV4 channel cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here the authors reveal that TRPV4 activation causes dose-dependent, CaMKII-mediated neuronal dysfunction and axonal degeneration vi
Externí odkaz:
https://doaj.org/article/27caf567bfbb4b33b6d71b47ffe0ae8f
Publikováno v:
Cell Metabolism. 35:555-570
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73018017aa34c9589edfb9eef81bdaa9
https://doi.org/10.1016/j.cmet.2023.03.006
https://doi.org/10.1016/j.cmet.2023.03.006
Autor:
Jean Paul Chadarevian, Sonia I. Lombroso, Graham C. Peet, Jonathan Hasselmann, Christina Tu, Dave E. Marzan, Joia Capocchi, Freddy S. Purnell, Kelsey M. Nemec, Alina Lahian, Adrian Escobar, Whitney England, Sai Chaluvadi, Carleigh A. O’Brien, Fazeela Yaqoob, William H. Aisenberg, Matias Porras-Paniagua, Mariko L. Bennett, Hayk Davtyan, Robert C. Spitale, Mathew Blurton-Jones, F. Chris Bennett
Publikováno v:
The Journal of experimental medicine, vol 220, iss 3
Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and expand the potential for microglia replacement, we engineered an inhibitor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd65ad6d31edb76b5662aa014420241f
https://doi.org/10.1084/jem.20220857
https://doi.org/10.1084/jem.20220857
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111053 (2014)
Recent studies have highlighted the important roles that "sensory" receptors (olfactory receptors, taste receptors, and orphan "GPR" receptors) play in a variety of tissues, including the kidney. Although several studies have identified important rol
Externí odkaz:
https://doaj.org/article/79d079ff9b4040e484f7845fd77b95f1
Autor:
Laura K. Aisenberg, Kimberly E. Rousseau, Katherine Cascino, Guido Massaccesi, William H. Aisenberg, Wensheng Luo, Kar Muthumani, David B. Weiner, Stephen S. Whitehead, Michael A. Chattergoon, Anna P. Durbin, Andrea L. Cox
Publikováno v:
JCI Insight
The Aedes aegypti mosquito transmits both dengue virus (DENV) and Zika virus (ZIKV) . Individuals in endemic areas are at risk for infection with both viruses, as well as for repeated DENV infection. In the presence of anti-DENV antibodies, outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ed55ddffaa29aca6c80dd6909b1f79
https://pubmed.ncbi.nlm.nih.gov/35588060
https://pubmed.ncbi.nlm.nih.gov/35588060
Autor:
Thomas E. Lloyd, Charlotte J. Sumner, Ute A. Hellmich, Erika Diehl, Dominick J. Rich, Alexander R. Lau, Jeremy M. Sullivan, Nicholas W. Zaccor, Brett A. McCray, Benedikt Goretzki, William H. Aisenberg
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of TRPV4 cause distinct, tissue-specific diseases, but the pathogenic mechanisms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4cbe48f7a71efdec62088f72005caa
https://doi.org/10.1038/s41467-021-21699-y
https://doi.org/10.1038/s41467-021-21699-y
Autor:
William H. Aisenberg, Brett A. McCray, Jeremy M. Sullivan, Erika Diehl, Lauren R. DeVine, Jonathan Alevy, Anna M. Bagnell, Patrice Carr, Jack K. Donohue, Benedikt Goretzki, Robert N. Cole, Ute A. Hellmich, Charlotte J. Sumner
Publikováno v:
Journal of Biological Chemistry. 298:101826
Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by alternative mechanisms remains unknown. Here, we show that the transien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a0bd81cf9cf2061975a2659f9e8648
https://doi.org/10.1016/j.jbc.2022.101826
https://doi.org/10.1016/j.jbc.2022.101826
Autor:
Charlotte J. Sumner, Mark N. Wu, Pamela C. Saavedra-Rivera, Jeremy M. Sullivan, Douglas N. Robinson, Kendra Takle Ruppell, Brian M. Woolums, Alexander R. Lau, Thomas E. Lloyd, Catherine Mamah, Brett A. McCray, Masashi Tabuchi, Yunpeng Yang, Hyun Sung, William H. Aisenberg, Yang Xiang, Bryan S. Larin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here, we show that in vivo expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6111fc5e71b0318201953aa8276c4f7b
https://doi.org/10.1038/s41467-020-16411-5
https://doi.org/10.1038/s41467-020-16411-5