Zobrazeno 1 - 10
of 67
pro vyhledávání: '"William Gradishar"'
Autor:
Ashlie Santaliz-Casiano, Dhruv Mehta, Oana C. Danciu, Hariyali Patel, Landan Banks, Ayesha Zaidi, Jermya Buckley, Garth H. Rauscher, Lauren Schulte, Lauren Ro Weller, Deanna Taiym, Elona Liko-Hazizi, Natalie Pulliam, Sarah M. Friedewald, Seema Khan, J. Julie Kim, William Gradishar, Scott Hegerty, Jonna Frasor, Kent F. Hoskins, Zeynep Madak-Erdogan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract African American (AA) women in the United States have a 40% higher breast cancer mortality rate than Non-Hispanic White (NHW) women. The survival disparity is particularly striking among (estrogen receptor positive) ER+ breast cancer cases.
Externí odkaz:
https://doaj.org/article/beae8bb87c8d4735bd2357ef0fcaedbc
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced malignancies was designed (ClinicalTrials.gov: NCT03363893). Here we rep
Externí odkaz:
https://doaj.org/article/b14be29b81754bafad04d4aa37714251
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4ff05e79a58f49b980db63215fe0a4b3
Autor:
Patricia I. Moreno, Fiona S. Horner, Joanna B. Torzewski, Jessica L. Thomas, William Gradishar, David Victorson, Frank J. Penedo
Publikováno v:
Contemporary Clinical Trials Communications, Vol 25, Iss , Pp 100870- (2022)
Women living with metastatic (stage IV) breast cancer face unique challenges, including arduous treatments, side effects, chronic symptom burden, and emotional distress. Nevertheless, most research has paradoxically focused on optimizing quality of l
Externí odkaz:
https://doaj.org/article/5196f853ec3f48edba2b5087f999362e
Autor:
Alain Mina, Carlos Galvez, Reem Karmali, Mary Mulcahy, Xinlei Mi, Masha Kocherginsky, Michael J Gurley, Neelima Katam, William Gradishar, Jessica K Altman, Michael G Ison, Dean Tsarwhas, Christopher George, Jane N Winter, Leo I. Gordon, Firas H Wehbe, Leonidas C Platanias
Publikováno v:
Cancers, Vol 14, Iss 9, p 2209 (2022)
Patients with a history of malignancy have been shown to be at an increased risk of COVID-19-related morbidity and mortality. Poorer clinical outcomes in that patient population are likely due to the underlying systemic illness, comorbidities, and th
Externí odkaz:
https://doaj.org/article/d9b453b5fe7f4f12a399f363fae6ea41
Autor:
Ami N Shah, Lisa Flaum, Irene Helenowski, Cesar A Santa-Maria, Sarika Jain, Alfred Rademaker, Valerie Nelson, Dean Tsarwhas, Massimo Cristofanilli, William Gradishar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundResponse rates to single agent immune checkpoint blockade in unselected pretreated HER2−negative metastatic breast cancer (MBC) are low. However, they may be augmented when combined with chemotherapy.MethodsWe conducted a single-arm, phas
Externí odkaz:
https://doaj.org/article/8f13f23e68dd4f8e940351b6de1ccf17
Autor:
William Gradishar
Publikováno v:
Drug Design, Development and Therapy, Vol 2009, Iss default, Pp 163-171 (2009)
William GradisharRobert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Despite the activity of standard chemotherapies in advanced breast cancer, disease progression remains inevita
Externí odkaz:
https://doaj.org/article/229b9b4534734e628bb6e1c0420afcdb
Publikováno v:
Clinical Breast Cancer. 23:350-362
Autor:
Meena Okera, Brian A. Van Tine, Joleen M. Hubbard, Minal Barve, Erika Hamilton, Monica M. Mita, Frances Valdes-Albini, Daniel Ahn, Admasu Mamuye, Joshua Pelham, Amy Yuet, Diana Yurewicz, Yanning Liu, Andres Machado Sandri, William J. Edenfield, Aki Morikawa, William Gradishar, Rajiv Kumar, Zev A. Wainberg
Publikováno v:
Cancer Research. 83:OT2-11
MT-5111 is a 55kD engineered toxin body targeting HER2 in solid tumors that binds to an epitope distinct from trastuzumab and pertuzumab, offering potential combination strategies with other HER2-targeting agents. MT-5111 works by internalizing, self
Autor:
Daniel L. Hall, Beverly J. Levine, Elizabeth Jeter, Allison Chandler, Janet A. Tooze, Jenna Duffecy, David Victorson, William Gradishar, Joseph Leach, Thomas Saphner, Mary Lou Smith, Frank Penedo, David C. Mohr, David Cella, Lynne I. Wagner
Publikováno v:
Journal of Behavioral Medicine. 45:771-781
Fear of recurrence (FoR) is prevalent among breast cancer survivors (BCS) and may be exacerbated by avoidance coping. This study examined BCS with avoidance coping and their engagement in a FoR eHealth intervention (FoRtitude).BCS (N = 196) with elev