Zobrazeno 1 - 10
of 10
pro vyhledávání: '"William Gowen-MacDonald"'
Autor:
Ashish Juvekar, Yang Zhang, Andrew Buesking, Min Wang, Dave Rominger, Joseph Rager, Stefan Ruepp, Kirsten Gallagher, Yue Zou, Miles Cowart, Xiaowei Wu, Sarah Pawley, Ryan Holmes, William Gowen-MacDonald, Kris Vaddi, Andrew Combs, Bruce Ruggeri, Peggy Scherle
Publikováno v:
Cancer Research. 82:2300-2300
Cell cycle deregulation is a hallmark of cancer and CDK inhibitors, specifically inhibiting CDK4/6 and blocking cells transition from the G1 to the S phase of the cell cycle are the first and only class of highly specific CDK inhibitors approved for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c8812126bcf09b1a0d1d424b34f3901
https://doi.org/10.1158/1538-7445.am2022-2300
https://doi.org/10.1158/1538-7445.am2022-2300
Autor:
Yang W. Zhang, Liang Lu, Min Wang, Dave Rominger, Stefan Ruepp, Kirsten Gallagher, William Gowen-MacDonald, Chaofeng Dai, Miles Cowart, Andrew Combs, Bruce Ruggeri, Peggy Scherle, Kris Vaddi
Publikováno v:
Molecular Cancer Therapeutics. 20:P237-P237
Cyclin-dependent kinase 9 (CDK9) is a master regulator of transcription that controls paused RNA polymerase II (RNAP2) release through phosphorylation of its carboxy-terminal domain, resulting in productive transcription elongation. CDK9 has been ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875804632ce1ebbfe48319ba43d04419
https://doi.org/10.1158/1535-7163.targ-21-p237
https://doi.org/10.1158/1535-7163.targ-21-p237
Autor:
Kris Vaddi, Alexander Grego, William Gowen-MacDonald, Neha Bhagwat, Xiaowei Wu, Jincong Zhuo, Peggy Scherle, Bruce Ruggeri, Miles Cowart, Andrew P. Combs, Min Wang
Publikováno v:
Cancer Research. 81:983-983
MCL1 is a member of the anti-apoptotic BCL2 family of proteins and plays a critical role in maintaining cellular homeostasis and promoting cell survival. It is frequently amplified in cancer and increased expression of MCL1 is associated with a highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e7a3926343414f1437ae8c4873c1e54
https://doi.org/10.1158/1538-7445.am2021-983
https://doi.org/10.1158/1538-7445.am2021-983
Autor:
Eliza Elliot, Kris Vaddi, Jack Carter, Liang Lu, Miles Cowart, Andrew P. Combs, Peggy Scherle, Philip Pitis, Brian Vidal, Bruce Ruggeri, Jacob Spruance, Hong Lin, Koichi Ito, William Gowen-MacDonald, Hsin-Yao Tang, Chaofeng Dai, Anjana Agarwal, Min Wang
Publikováno v:
Cancer Research. 81:1139-1139
SWI/SNF complexes play an important role in controlling gene expression by remodeling chromatin. SMARCA2 (BRM) and SMARCA4 (BRG1) are the core subunits of the SWI/SNF complexes which contain ATPase domain and DNA binding bromodomain. SMARCA4 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197dc813c8f7089106fc5bd785769a23
https://doi.org/10.1158/1538-7445.am2021-1139
https://doi.org/10.1158/1538-7445.am2021-1139
Autor:
Michael W. Lark, Aimee L. Crombie, William Gowen-MacDonald, Richard Carr, Michael Koblish, Conrad L. Cowan, Jonathan D. Violin, David H. Rominger, Edward R. Siuda
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:254-262
Prescription opioids are a mainstay in the treatment of acute moderate to severe pain. However, chronic use leads to a host of adverse consequences including tolerance and opioid-induced hyperalgesia (OIH), leading to more complex treatment regimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98abb335ba94d232cfe85452a2a9be04
https://doi.org/10.1124/jpet.117.241117
https://doi.org/10.1124/jpet.117.241117
Autor:
Srdan Verstovsek, Yang Zhang, Ross L. Levine, Alexander Grego, William Gowen-MacDonald, Taghi Manshouri, Dimitrios Angelis, Hong Lin, Peggy Scherle, Juan Luengo, Min Wang, Kris Vaddi, Neha Bhagwat, Dave Rominger, Tom Emm, Bruce Ruggeri, Raul A. Leal, Rupa Shetty, Friederike Pastore, Divya Chugani-Mahtani
Publikováno v:
Cancer Research. 80:2915-2915
Protein arginine methyltransferase 5 (PRMT5) is the major type II PRMT that catalyzes the formation of symmetrical dimethyl arginine (SDMA) on protein substrates and plays important roles in various cellular pathways including tumorigenesis. PRMT5 ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22259afd761bc23c7d8f64650167a2b
https://doi.org/10.1158/1538-7445.am2020-2915
https://doi.org/10.1158/1538-7445.am2020-2915
Autor:
Michael, Koblish, Richard, Carr, Edward R, Siuda, David H, Rominger, William, Gowen-MacDonald, Conrad L, Cowan, Aimee L, Crombie, Jonathan D, Violin, Michael W, Lark
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(2)
Prescription opioids are a mainstay in the treatment of acute moderate to severe pain. However, chronic use leads to a host of adverse consequences including tolerance and opioid-induced hyperalgesia (OIH), leading to more complex treatment regimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48d85ac6f3614ca459a75aafbc4f4906
https://pubmed.ncbi.nlm.nih.gov/28533287
https://pubmed.ncbi.nlm.nih.gov/28533287
Publikováno v:
Pain Management Nursing. 18:72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45556f5202e7ed3824fa4d2a701760e4
https://doi.org/10.1016/j.pmn.2017.02.193
https://doi.org/10.1016/j.pmn.2017.02.193
Autor:
Richard Carr, Conrad L. Cowan, Jonathan D. Violin, William Gowen-MacDonald, Michael W. Lark, Edward R. Siuda, David H. Rominger, Aimee L. Crombie, M. Wobblish
Publikováno v:
The Journal of Pain. 18:S32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5133cb7a81a88e98490f3149666900c7
https://doi.org/10.1016/j.jpain.2017.02.116
https://doi.org/10.1016/j.jpain.2017.02.116
Publikováno v:
Current opinion in pharmacology. 16
G protein-coupled receptors (GPCRs), in recent years, have been shown to signal via multiple distinct pathways. Furthermore, biased ligands for some receptors can differentially stimulate or inhibit these pathways versus unbiased endogenous ligands o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a1a37d343db7bdb6b1fdfb0330a771
https://pubmed.ncbi.nlm.nih.gov/24834870
https://pubmed.ncbi.nlm.nih.gov/24834870