Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target

Autor: Ryan W. Baranowski, Jessica L. Braun, Briana L. Hockey, Jenalyn L. Yumol, Mia S. Geromella, Colton J.F. Watson, Nigel Kurgan, Holt N. Messner, Kennedy C. Whitley, Adam J. MacNeil, Guillemette Gauquelin-Koch, Fabrice Bertile, William Gittings, Rene Vandenboom, Wendy E. Ward, Val A. Fajardo

Publikováno v: iScience, Vol 26, Iss 7, Pp 107047- (2023)

Summary: We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions (BION-M1, rodent research [RR]1, RR9, and R

Externí odkaz: https://doaj.org/article/e4d4f424c12d421f9b505e655757ff9a

Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro

Autor: Kristian Overgaard, William Gittings, Rene Vandenboom

Publikováno v: Overgaard, K, Gittings, W & Vandenboom, R 2022, ' Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro ', Pflugers Archiv European Journal of Physiology, vol. 474, no. 6, pp. 637-646 . https://doi.org/10.1007/s00424-022-02681-z

The influence of moderately elevated extracellular potassium concentration ([K+]) on muscle force has marked similarities to that of posttetanic potentiation (PTP) in that twitch force may be enhanced whilst high-frequency force is depressed. The pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7048d9e12ad64b67b4807a478eb33527
https://doi.org/10.1007/s00424-022-02681-z

K+-induced Potentiation And Post-tetanic Potentiation Act Via Independent Mechanisms In Mouse Fast-twitch Muscle

Autor: Kristian Overgaard, William Gittings, Rene Vandenboom

Publikováno v: Medicine & Science in Sports & Exercise. 54:386-386

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fe2bfdb80ebc5d3c49642c221e3de69
https://doi.org/10.1249/01.mss.0000879912.94004.36

Myosin light chain phosphorylation is required for peak power output of mouse fast skeletal muscle in vitro

Autor: Joshua Bowslaugh, Rene Vandenboom, William Gittings

Publikováno v: Pflügers Archiv - European Journal of Physiology. 468:2007-2016

The skeletal myosin light chain kinase (skMLCK) catalyzed phosphorylation of the myosin regulatory light chain (RLC) is associated with potentiation of force, work, and power in rodent fast twitch muscle. The purpose of this study was to compare conc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa365eacd85c49721fb61cdf77221753
https://doi.org/10.1007/s00424-016-1897-3

Total Polyphenol Content and Antioxidant Capacity of Tea Bags: Comparison of Black, Green, Red Rooibos, Chamomile and Peppermint over Different Steep Times

Autor: William Gittings, Yasmeen Elhalaby, Wendy E. Ward, Michael D. McAlpine, Riley Cleverdon

Publikováno v: Beverages; Volume 4; Issue 1; Pages: 15
Beverages, Vol 4, Iss 1, p 15 (2018)

Globally, traditional and herbal teas are a prominent dietary source of polyphenols, and represent a class of bioactive molecules that are closely associated with a variety of health benefits. Most consumers prepare tea using tea bags, although there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e2a78fd59b6ff88c547bf5589d9919