Zobrazeno 1 - 10
of 135
pro vyhledávání: '"William Gibb"'
Autor:
Guinever Eustaquio do Imperio, Enrrico Bloise, Mohsen Javam, Phetcharawan Lye, Andrea Constantinof, Caroline Dunk, Fernando Marcos dos Reis, Stephen James Lye, William Gibb, Tania M. Ortiga-Carvalho, Stephen Giles Matthews
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 2, Pp 591-604 (2018)
Background/Aims: The ATP-binding cassette (ABC) transporters mediate drug biodisposition and immunological responses in the placental barrier. In vitro infective challenges alter expression of specific placental ABC transporters. We hypothesized that
Externí odkaz:
https://doaj.org/article/9cd15e3602244836a7460979bdfb2849
Autor:
Enrrico Bloise, Sophie Petropoulos, Majid Iqbal, Alisa Kostaki, Tania Maria Ortiga-Carvalho, William Gibb, Stephen G. Matthews
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 3, Pp 1044-1050 (2017)
Background/Aims: Viral infection during pregnancy is known to affect the fetal brain. The toll-like receptor (TLR)-3 is a pattern recognition receptor activated by viruses known to elicit adverse fetal neurological outcomes. The P-glycoprotein (P-gp)
Externí odkaz:
https://doaj.org/article/03dad7106e744a668404f7dd1d44afdb
Autor:
Phetcharawan Lye, Enrrico Bloise, Lubna Nadeem, Chun Peng, William Gibb, Tania M. Ortiga-Carvalho, Stephen J. Lye, Stephen G. Matthews
Publikováno v:
Cells, Vol 8, Iss 10, p 1150 (2019)
Extravillous trophoblasts (EVT) migration into the decidua is critical for establishing placental perfusion and when dysregulated, may lead to pre-eclampsia (PE) and intrauterine growth restriction (IUGR). The breast cancer resistance protein (BCRP;
Externí odkaz:
https://doaj.org/article/fb6dcefc828945c8a940d6125c155a85
Autor:
Enrrico Bloise, Manzerul Bhuiyan, Melanie C Audette, Sophie Petropoulos, Mohsen Javam, William Gibb, Stephen G Matthews
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65728 (2013)
Lipopolysaccharide (LPS) in high doses inhibits placental multidrug resistance P-glycoprotein (P-gp--Abcb1a/b) and breast cancer resistance protein (BCRP--Abcg2). This potentially impairs fetal protection against harmful factors in the maternal circu
Externí odkaz:
https://doaj.org/article/b8966366a81a4212ba2df6f1c8936517
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56525 (2013)
Retention of substances from systemic circulation in the brain and testes are limited due to high levels of P-glycoprotein (P-gp) in the luminal membranes of brain and testes capillary endothelial cells. From a clinical perspective, P-gp rapidly extr
Externí odkaz:
https://doaj.org/article/1758b641c4004cf9b6a4c0099e1ab9b5
Autor:
Majid Iqbal, Hay Lam Ho, Sophie Petropoulos, Vasilis G Moisiadis, William Gibb, Stephen G Matthews
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43022 (2012)
Placental P-glycoprotein (P-gp) acts to protect the developing fetus from exogenous compounds. This protection declines with advancing gestation leaving the fetus and fetal brain vulnerable to these compounds and potential teratogens in maternal circ
Externí odkaz:
https://doaj.org/article/a8ddc0e34ec54516b9f406e4c1ab81a7
Publikováno v:
Obstetrics and Gynecology International, Vol 2012 (2012)
Human fetal membranes play an important role in term and preterm labor and are responsive to steroids. We examined the expression of steroid receptor coactivators in fetal membranes obtained prior to and following labor at term. Proteins were localiz
Externí odkaz:
https://doaj.org/article/e36b180cfbe548dea0a44e0fbb268a96
Autor:
Danielle T. Miller, William Gibb, Holly Caretta‐Weyer, Kristen Ng, Stefanie S. Sebok‐Syer, Michael A. Gisondi
Publikováno v:
AEM Education and Training. 6
The goal of this study was to develop and evaluate a novel curriculum and assessment tool for Core Entrustable Professional Activity (EPA) 10 competencies and entrustment scoring in a cohort of medical students in their emergency medicine (EM) clerks
Publikováno v:
Day 4 Thu, October 01, 2020.
An experimental procedure was developed to incorporate the mechanisms of Gas-Cycling Enhanced Oil Recovery (GCEOR) phase behavior, IFT change, swelling, viscosity reduction and residual-liquid shrinkage in the presence of porous media possessing prop
Publikováno v:
Day 2 Tue, September 01, 2020.
A radial-flow, matrix-frac experimental procedure was developed to incorporate the mechanisms of Gas-Cycling Enhanced Oil Recovery (GCEOR) phase behavior, IFT change, swelling, viscosity reduction and residual-liquid shrinkage in the presence of poro