Zobrazeno 1 - 10
of 13
pro vyhledávání: '"William G. Montgomery"'
Autor:
Prasad Srikakulapu, Gorav Ailawadi, Matthew J. Johnsrude, Akshaya K. Meher, Gilbert R. Upchurch, Michael Spinosa, Melissa Lempicki, Coleen A. McNamara, Norbert Leitinger, William G. Montgomery
Publikováno v:
Am J Pathol
B cell–activating factor (BAFF), part of a tumor necrosis factor family of cytokines, was recently identified as a regulator of atherosclerosis; however, its role in aortic aneurysm has not been determined. Here, the study examined the effect of se
Autor:
Morgan Salmon, Michael Spinosa, Robert B. Hawkins, William G. Montgomery, Alexis Mast, Gorav Ailawadi, Ashish Sharma, J. Michael Cullen, Gang Su, Gilbert R. Upchurch, Anna Z. Fashandi, Guanyi Lu
Publikováno v:
J Surg Res
Background Male gender is a well-established risk factor for abdominal aortic aneurysm (AAA), whereas estrogen is hypothesized to play a protective role. Although rupture rates are higher in women, these reasons remain unknown. In the present study,
Autor:
Basil Schaheen, Gilbert R. Upchurch, William G. Montgomery, John P. Davis, Gary K. Owens, Juanita L. Merchant, Nicolas H. Pope, Zendra E. Zehner, Gorav Ailawadi, Ashish Sharma, Morgan Salmon, Michael Spinosa, William F. Johnston
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:73-88
Objective— The goal of this study was to determine the role of ZFP148 (zinc-finger protein 148) in aneurysm formation. Approach and Results— ZFP148 mRNA expression increased at day 3, 7, 14, 21, and 28 after during abdominal aortic aneurysm forma
Autor:
Gorav Ailawadi, Michael Spinosa, Guanyi Lu, J. Michael Cullen, Michael S. Conte, Akshaya K. Meher, William G. Montgomery, Robert B. Hawkins, Anna Z. Fashandi, Ashish Sharma, Gang Su, Gilbert R. Upchurch, Morgan Salmon
Publikováno v:
Journal of Vascular Surgery. 68:93S-103S
Objective Resolvins have been shown to attenuate inflammation, whereas NETosis, the process of neutrophils releasing neutrophil extracellular traps (NETs), produces increased inflammation. It is hypothesized that treatment of animals with resolvin D1
Autor:
Gilbert R. Upchurch, Alexander H. Shannon, William G. Montgomery, Gang Su, Gorav Ailawadi, Guanyi Lu, J. Michael Cullen, Michael Spinosa, Morgan Salmon
Publikováno v:
J Surg Res
BACKGROUND: Female sex protects against abdominal aortic aneurysms (AAAs); however, the mechanisms behind these sex-based differences remain unknown. The purpose of this study was to explore the role of sex and sex hormones in AAA formation among swi
Autor:
William G. Montgomery, Michael Spinosa, Gorav Ailawadi, W. Forrest Johnston, Zachary Tyerman, Morgan Salmon, Guanyi Lu, J. Michael Cullen, Erik J. Scott, Jolian Dahl, Alexander H. Shannon, Gilbert R. Upchurch
Publikováno v:
Journal of Visualized Experiments.
Large animal models to study abdominal aortic aneurysms are sparse. The purpose of this model is to create reproducible, clinically significant infrarenal abdominal aortic aneurysms (AAA) in swine. To achieve this, we use a combination of balloon ang
Autor:
Prasad Srikakulapu, William G. Montgomery, Gorav Ailawadi, Norbert Leitinger, Vlad Serbulea, Michael Spinosa, Srabani Sahu, Akshaya K. Meher, Gilbert R. Upchurch, Coleen A. McNamara
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Marginal zone and follicular B cells together constitute the B2 cell population, which is known to promote cardiovascular diseases by secretion of pathogenic antibodies. However, it is not completely understood how B2 cells are activated. Here, we te
Autor:
Gang Su, William G. Montgomery, Gorav Ailawadi, Taryn E. Hassinger, J. Michael Cullen, Anna Z. Fashandi, Gilbert R. Upchurch, Ashish Sharma, Guanyi Lu, Morgan Salmon, Michael Spinosa
Publikováno v:
Surgery. 164(5)
Background Tamsulosin, an α1A-adrenergic receptor inhibitor, is prescribed to treat benign prostatic hyperplasia in men >60 years of age, the same demographic most susceptible to abdominal aortic aneurysm. The goal of this study was to investigate t
Autor:
Gilbert R. Upchurch, Anna Z. Fashandi, Guanyi Lu, J. Michael Cullen, Michael Spinosa, Alexander H. Shannon, Gorav Ailawadi, William G. Montgomery, Ashish Sharma, Gang Su, Morgan Salmon, W. Forrest Johnston
Publikováno v:
Journal of vascular surgery. 70(1)
Few large-animal models exist for the study of aortic aneurysms. β-Aminopropionitrile (BAPN) is a compound known to cause aortic aneurysms by inhibiting lysyl oxidase, a collagen cross-linking enzyme. It is hypothesized that BAPN plus aneurysm induc
Autor:
Robert B. Hawkins, Gang Su, Anna Z. Fashandi, Morgan Salmon, Michael Spinosa, Guanyi Lu, William G. Montgomery, J. Michael Cullen, Gilbert R. Upchurch, Gorav Ailawadi
Publikováno v:
Surgery. 163(2)
Given the unknown biologic antecedents before aortic aneurysm rupture, the purpose of this study was to establish a reproducible model of aortic aneurysm rupture.We fed 7-week-old apolipoprotein E deficient mice a high-fat diet for 4 weeks and osmoti