Zobrazeno 1 - 10
of 28
pro vyhledávání: '"William G. McDonald"'
Autor:
Patrick A. Vigueira, Kyle S. McCommis, George G. Schweitzer, Maria S. Remedi, Kari T. Chambers, Xiaorong Fu, William G. McDonald, Serena L. Cole, Jerry R. Colca, Rolf F. Kletzien, Shawn C. Burgess, Brian N. Finck
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 2042-2053 (2014)
Carrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that facili
Externí odkaz:
https://doaj.org/article/0d9bb6c80ceb445b921d7c646f9c7d02
Autor:
Jerry R Colca, William G McDonald, Gregory S Cavey, Serena L Cole, Danielle D Holewa, Angela S Brightwell-Conrad, Cindy L Wolfe, Jean S Wheeler, Kristin R Coulter, Peter M Kilkuskie, Elena Gracheva, Yulia Korshunova, Michelle Trusgnich, Robert Karr, Sandra E Wiley, Ajit S Divakaruni, Anne N Murphy, Patrick A Vigueira, Brian N Finck, Rolf F Kletzien
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61551 (2013)
Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects that are mediated via activation of the transcription factor PPARγ
Externí odkaz:
https://doaj.org/article/810bfe5fc88043a1a3d87fdcdaabf016
Autor:
Lalita Oonthonpan, Rolf F. Kletzien, Eric B. Taylor, Jerry R. Colca, Serena L. Cole, George G. Schweitzer, William G. McDonald, Patrick A. Vigueira, Wesley T. Hodges, Brian N. Finck, Kyle S. McCommis
Publikováno v:
Experimental Physiology. 102:985-999
Rosiglitazone and pioglitazone are thiazolidinedione (TZD) compounds that have been used clinically as insulin-sensitizing drugs and are generally believed to mediate their effects via activation of the peroxisome proliferator-activated receptor γ (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f7b85b1cc3600423efdcc0a0c3e843
https://doi.org/10.1113/ep086380
https://doi.org/10.1113/ep086380
Publikováno v:
Hepatology Communications
Modifying the entry of pyruvate into mitochondria may provide a unique approach to treat metabolic disease. The pharmacology of a new class of insulin sensitizers directed against a newly identified mitochondrial target may treat many aspects of nona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c45ed1281c8293d7955e51a265811
https://doi.org/10.1002/hep4.1036
https://doi.org/10.1002/hep4.1036
Autor:
ILKe Nalbantoglu, Hideji Fujiwara, Christopher L. Holley, Brian N. Finck, William G. McDonald, Elizabeth M. Brunt, Wesley T. Hodges, Kyle S. McCommis, Jean E. Schaffer, Jerry R. Colca
Publikováno v:
Hepatology. 65:1543-1556
Diseases of the liver related to metabolic syndrome have emerged as the most common and undertreated hepatic ailments. The cause of nonalcoholic fatty liver disease is the aberrant accumulation of lipid in hepatocytes, though the mechanisms whereby t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6898942888d3a4655a3fec4bee737a
https://doi.org/10.1002/hep.29025
https://doi.org/10.1002/hep.29025
Publikováno v:
Diabetes. 67
Thiazolidinediones (TZDs) enhance insulin sensitivity and have efficacy for treating nonalcoholic steatohepatitis (NASH). However, the use of TZDs, like rosiglitazone and pioglitazone, has been curtailed by significant side effects mediated via the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f7d774ab434847a454341b633efc7e1
https://doi.org/10.2337/db18-237-lb
https://doi.org/10.2337/db18-237-lb
Autor:
Kyle S. McCommis, Rolf F. Kletzien, Brian N. Finck, Xiaorong Fu, Patrick A. Vigueira, Shawn C. Burgess, Serena L. Cole, Jerry R. Colca, Kari T. Chambers, William G. McDonald, George G. Schweitzer, Maria S. Remedi
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 2042-2053 (2014)
SummaryCarrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6e5ee8cbc898411b403e220f21c7de
Autor:
Trevor A. Tyson, Patrik Brundin, Jerry R. Colca, Jennifer A. Steiner, Erin N. Hildebrandt, Sonia George, Jeffrey H. Kordower, Emily Schulz, Martha L. Escobar Galvis, Zachary Madaj, Jeremy M. Van Raamsdonk, William G. McDonald, Emily Machiela, Anamitra Ghosh
Publikováno v:
Science Translational Medicine. 8
Mitochondrial and autophagic dysfunction as well as neuroinflammation are involved in the pathophysiology of Parkinson's disease (PD). We hypothesized that targeting the mitochondrial pyruvate carrier (MPC), a key controller of cellular metabolism th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f42f42f37c113417699a4d3e524ebf
https://doi.org/10.1126/scitranslmed.aag2210
https://doi.org/10.1126/scitranslmed.aag2210
Autor:
Alexander Y. Andreyev, Alejandro P. Heuck, William G. McDonald, Melvin I. Simon, Robert R. Henry, Estelle A. Wall, Theodore P. Ciaraldi, Sandra E. Wiley, Mattias Loviscach, Nagendra Yadava, David A. Ferrick, Ajit S. Divakaruni, Susanna Petrosyan, George W. Rogers, Anne N. Murphy, Jerry R. Colca
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5422-5427
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid metabolism. We report that clinically relevant concentrations of thiazolidinediones (TZDs), a widely used class of insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba61887b682c43ad1ae60a3af85bdb9
https://doi.org/10.1073/pnas.1303360110
https://doi.org/10.1073/pnas.1303360110
Autor:
William G McDonald
Publikováno v:
MOJ Public Health. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b896e3a10fcf34412d440a5145c36ec
https://doi.org/10.15406/mojph.2016.04.00068
https://doi.org/10.15406/mojph.2016.04.00068