Zobrazeno 1 - 10
of 315
pro vyhledávání: '"William G. Kaelin"'
Autor:
Diana D. Shi, Joyce H. Lee, Adam C. Wang, Januka Khanal, Wenhua Gao, William G. Kaelin, Jr., Samuel K. McBrayer
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102281- (2023)
Summary: Lower-grade gliomas exhibit a high prevalence of isocitrate dehydrogenase 1 (IDH1) mutations, but faithful models for studying these tumors are lacking. Here, we present a protocol to establish a genetically engineered mouse (GEM) model of g
Externí odkaz:
https://doaj.org/article/28d231ea93034d8da81fffb340a70d54
Autor:
William G. Kaelin Jr.
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell renal cell carcinomas (ccRCCs), and paragangliomas. This Review descri
Externí odkaz:
https://doaj.org/article/003da503ec7544aeab4bc42bebe35058
Autor:
Ratnam S. Seelan, Meredith Irwin, Petra van der Stoop, Chiping Qian, William G. Kaelin, Jr, Wanguo Liu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 3, Pp 195-203 (2002)
p73, a member of the p53 family, is overexpressed in many cancers. To understand the mechanism(s) underlying this overexpression, we have undertaken a detailed characterization of the human p73 promoter. The promoter is strongly activated in cells ex
Externí odkaz:
https://doaj.org/article/60a5e84e632349cab6c33a1dbad161f1
Autor:
Michal Safran, William Y. Kim, Andrew L. Kung, James W. Horner, Ron A. DePinho, William G. Kaelin
Publikováno v:
Molecular Imaging, Vol 2 (2003)
Conditional alleles containing LoxP recombination sites, in conjunction with Cre recombinase delivered by a variety of means, allows for spatial and temporal control of gene expression in mouse models. Here we describe a mouse strain in which a lucif
Externí odkaz:
https://doaj.org/article/dbe6f2f367864f1e9dc51d510c172587
Autor:
Treg Grubb, Smruthi Maganti, John Michael Krill-Burger, Cameron Fraser, Laura Stransky, Tomas Radivoyevitch, Kristopher A. Sarosiek, Francisca Vazquez, William G. Kaelin, Abhishek A. Chakraborty
Publikováno v:
Clinical Cancer Research. 28:4689-4701
Purpose: Advanced/metastatic forms of clear-cell renal cell carcinomas (ccRCC) have limited therapeutic options. Genome-wide genetic screens have identified cellular dependencies in many cancers. Using the Broad Institute/Novartis combined short hair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ccd8b85041f9bda4cafbd479bceb1ca
https://doi.org/10.1158/1078-0432.ccr-22-0669
https://doi.org/10.1158/1078-0432.ccr-22-0669
Autor:
William G. Kaelin, Simon T. Barry, Christopher J. Lord, Susan Ashton, David Pellman, Sabina Signoretti, David E. Root, Jon Travers, Kim Maratea, Elizabeth J. Pease, Colm J. Ryan, Stefano Cairo, Paula Taylor, Laura Brulle-Soumare, Quang-De Nguyen, Dennis M. Bonal, Glenn S. Cowley, Samuel K. McBrayer, Scott T. Younger, Elizabeth Buss, Aditi Gulati, Jesse S. Novak, Abdallah Flaifel, Rebecca B. Jennings, Alexander Spektor, Rachel Brough, Abhishek A. Chakraborty, Raquel Fonseca, Matthew G. Oser
Supplementary Table S5 shows RNA sequencing data and gene set enrichment analysis of NCI-H82 cells Dox-On pRB cells grown in the presence or absence of DOX and then treated with DMSO or AZD2811.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86489d55cf16ceed89defe77d5f66d58
https://doi.org/10.1158/2159-8290.22533007.v1
https://doi.org/10.1158/2159-8290.22533007.v1
Autor:
William G. Kaelin, Simon T. Barry, Christopher J. Lord, Susan Ashton, David Pellman, Sabina Signoretti, David E. Root, Jon Travers, Kim Maratea, Elizabeth J. Pease, Colm J. Ryan, Stefano Cairo, Paula Taylor, Laura Brulle-Soumare, Quang-De Nguyen, Dennis M. Bonal, Glenn S. Cowley, Samuel K. McBrayer, Scott T. Younger, Elizabeth Buss, Aditi Gulati, Jesse S. Novak, Abdallah Flaifel, Rebecca B. Jennings, Alexander Spektor, Rachel Brough, Abhishek A. Chakraborty, Raquel Fonseca, Matthew G. Oser
This document contains the text for the supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5732b09751dfedc3f31258a710153e32
https://doi.org/10.1158/2159-8290.22533001
https://doi.org/10.1158/2159-8290.22533001
Autor:
William G. Kaelin, Simon T. Barry, Christopher J. Lord, Susan Ashton, David Pellman, Sabina Signoretti, David E. Root, Jon Travers, Kim Maratea, Elizabeth J. Pease, Colm J. Ryan, Stefano Cairo, Paula Taylor, Laura Brulle-Soumare, Quang-De Nguyen, Dennis M. Bonal, Glenn S. Cowley, Samuel K. McBrayer, Scott T. Younger, Elizabeth Buss, Aditi Gulati, Jesse S. Novak, Abdallah Flaifel, Rebecca B. Jennings, Alexander Spektor, Rachel Brough, Abhishek A. Chakraborty, Raquel Fonseca, Matthew G. Oser
Supplementary Figure S1 shows RB1 is synthetic lethal with multiple genes that regulate chromosomal segregation. Supplementary Figure S2 shows genetic inactivation of AURKB is synthetic lethal with RB1 loss in NCI-H82 cells. Supplementary Figure S3 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9edcc3ee48d8078c48fd9b3d57494e
https://doi.org/10.1158/2159-8290.22533022
https://doi.org/10.1158/2159-8290.22533022
Autor:
William G. Kaelin, Sabina Signoretti, Michelle Chang, Jing Zhou, Steven E. Schumacher, Rameen Beroukhim, Chuan Shen
Supplementary Figures 1-6, Tables 1-2, Methods from Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6114c186c63e3dc6f3e10ac3633fbf7
https://doi.org/10.1158/2159-8290.22529411.v1
https://doi.org/10.1158/2159-8290.22529411.v1
Autor:
Abhishek A. Chakraborty, William G. Kaelin, Francisca Vazquez, Kristopher A. Sarosiek, Tomas Radivoyevitch, Laura Stransky, Cameron Fraser, John Michael Krill-Burger, Smruthi Maganti, Treg Grubb
Purpose:Advanced/metastatic forms of clear-cell renal cell carcinomas (ccRCC) have limited therapeutic options. Genome-wide genetic screens have identified cellular dependencies in many cancers. Using the Broad Institute/Novartis combined short hairp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae42832492864fe261b77bb03af161d
https://doi.org/10.1158/1078-0432.c.6532899
https://doi.org/10.1158/1078-0432.c.6532899