Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William G. Herrick"'
Autor:
Yulia Y. Tyurina, Alexandr A. Kapralov, Vladimir A. Tyurin, Galina Shurin, Andrew A. Amoscato, Dhivyaa Rajasundaram, Hua Tian, Yuri L. Bunimovich, Yulia Nefedova, William G. Herrick, Ralph E. Parchment, James H. Doroshow, Hulya Bayir, Apurva K. Srivastava, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102650- (2023)
Growing cancer cells effectively evade most programs of regulated cell death, particularly apoptosis. This necessitates a search for alternative therapeutic modalities to cause cancer cell's demise, among them – ferroptosis. One of the obstacles to
Externí odkaz:
https://doaj.org/article/456757eed77a40cd9dc6f115fa83021a
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
This document includes Supplementary Methods, validation data (Figures S1 and S2), complete PD data sets (Figures S3-S7), and Supplementary Tables detailing statistical analyses and assay validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2112c24bc490ca09fb4765d6616478c1
https://doi.org/10.1158/1535-7163.22520812.v1
https://doi.org/10.1158/1535-7163.22520812.v1
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4c9076603dbbe6d0c3610e28659c6
https://doi.org/10.1158/1535-7163.c.6542791
https://doi.org/10.1158/1535-7163.c.6542791
Autor:
William G. Herrick, Jeevan Govindharajulu, Ralph E. Parchment, James H. Doroshow, Apurva K. Srivastava
Publikováno v:
Cancer Research. 83:6143-6143
Background: The recent discovery that multiple chemo- and immuno-therapies activate non-apoptotic cell death pathways such as necroptosis, pyroptosis, and ferroptosis in cancer cells has necessitated development of pharmacodynamic biomarker assays to
Autor:
William G. Herrick, Shelly R. Peyton, Shruti Rattan, Alfred J. Crosby, Thuy V. Nguyen, Christopher W. Barney, Michael S. Grunwald
Publikováno v:
Cellular and Molecular Bioengineering. 8:333-348
Smooth muscle cell (SMC) invasion into plaques and subsequent proliferation is a major factor in the progression of atherosclerosis. During disease progression, SMCs experience major changes in their microenvironment, such as what integrin-binding si
Autor:
Thuy V. Nguyen, Samantha McRae, William G. Herrick, Marianne Sleiman, Todd Emrick, Shelly R. Peyton
Publikováno v:
Biomacromolecules. 14:2294-2304
We report here the synthesis of a new class of hydrogels with an extremely wide range of mechanical properties suitable for cell studies. Mechanobiology has emerged as an important field in bioengineering, in part due to the development of synthetic
Publikováno v:
Manual of Industrial Microbiology and Biotechnology
With the development of recombinant DNA technology, industrial enzymes are increasingly being produced in heterologous hosts, particularly in the bacterium Escherichia coli and the yeasts Saccharomyces cerevisiae and Pichia pastoris. Although mammali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb468dea4a4a4e3c706588ac0e854177
https://doi.org/10.1128/9781555816827.ch37
https://doi.org/10.1128/9781555816827.ch37
Publikováno v:
2014 40th Annual Northeast Bioengineering Conference (NEBEC).
Tumor progression is coincident with mechanochemical changes in the extracellular matrix (ECM). We hypothesized that tumor stroma stiffening, alongside a shift in the ECM composition from a basement membrane-like microenvironment toward a dense netwo
Publikováno v:
Biomaterials. 35(22)
Tumor progression is coincident with mechanochemical changes in the extracellular matrix (ECM). We hypothesized that tumor stroma stiffening, alongside a shift in the ECM composition from a basement membrane-like microenvironment toward a dense netwo