Zobrazeno 1 - 10
of 214
pro vyhledávání: '"William G. Haynes"'
Autor:
Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new
Externí odkaz:
https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677
Autor:
Daniel Lindén, Andrea Ahnmark, Piero Pingitore, Ester Ciociola, Ingela Ahlstedt, Anne-Christine Andréasson, Kavitha Sasidharan, Katja Madeyski-Bengtson, Magdalena Zurek, Rosellina M. Mancina, Anna Lindblom, Mikael Bjursell, Gerhard Böttcher, Marcus Ståhlman, Mohammad Bohlooly-Y, William G. Haynes, Björn Carlsson, Mark Graham, Richard Lee, Sue Murray, Luca Valenti, Sanjay Bhanot, Peter Åkerblad, Stefano Romeo
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 49-61 (2019)
Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributo
Externí odkaz:
https://doaj.org/article/f77b71978d104e8aa87a52faaeaa4522
Autor:
Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Publikováno v:
Molecular Metabolism, Vol 10, Iss , Pp 74-86 (2018)
Objective: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Methods: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pa
Externí odkaz:
https://doaj.org/article/68b32ae0380845d7a7bc838551e3e8a7
Autor:
lyndsey E. Dubose, David J. Moser, Taylor Stecklein, Emily Harlynn, William G. Haynes, Gary L. Pierce
Publikováno v:
Artery Research, Vol 16 (2016)
Introduction: Higher aortic stiffness and central blood pressure (BP) are associated with reduced cognitive performance in older adults. Cognitive performance tends to be higher in older women compared with older men, unexplained by differences in ye
Externí odkaz:
https://doaj.org/article/fe62ecf25db840bb9ad0c105fbb45280
Publikováno v:
Artery Research, Vol 8, Iss 4 (2014)
Externí odkaz:
https://doaj.org/article/540d5a8a56304b858c5db4b79ccef974
Autor:
Stephen Burgess, Amy M. Mason, Andrew J. Grant, Eric A.W. Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G. Haynes, G. Kees Hovingh, Lotte Bjerre Knudsen, John C. Whittaker, Dipender Gill
Publikováno v:
American journal of human genetics. 110(2):195-214
Evidence on the validity of drug targets from randomized trials is reliable but typically expensive and slow to obtain. In contrast, evidence from conventional observational epidemiological studies is less reliable because of the potential for bias f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24c391d41cbb6c76d403e7b379eec23
https://doi.org/10.1016/j.ajhg.2022.12.017
https://doi.org/10.1016/j.ajhg.2022.12.017
Autor:
Verena Zuber, Lotte Bjerre Knudsen, Iyas Daghlas, Anette K. Olsen, William G Haynes, Joanna M M Howson, Dipender Gill, Ville Karhunen, Marijana Vujkovic
Publikováno v:
Diabetologia
Aims/hypothesis The aim of this study was to leverage human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide (GIP) signalling. Methods Data were obtained from summary statistics of large-scale ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5368b5d09ccdf61f78af7a2365953a4a
https://doi.org/10.1007/s00125-021-05564-7
https://doi.org/10.1007/s00125-021-05564-7
Autor:
William G. Haynes, Ji Seon Lee, Seung Ah Lee, Young Do Koo, Kyong Soo Park, Ratan Bhat, Paula G.F. Quaresma, Sung Soo Chung, Young Joo Park, Young-Bum Kim
Publikováno v:
Metabolism
Background and purpose In addition to the central nervous system-mediated action, leptin also directly induces fatty acid oxidation in skeletal muscle. Rapid induction of FAO by leptin is mediated by the AMP-activated protein kinase (AMPK) pathway, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de923d5fb295c1f6994f438d677d194
https://doi.org/10.1016/j.metabol.2019.03.004
https://doi.org/10.1016/j.metabol.2019.03.004
Autor:
William G. Haynes, Christopher J Wagner, Graziela Z. Kalil, Gary L. Pierce, Jess G. Fiedorowicz, Amy L. Sindler, Tiwaloluwa Ajibewa, Abbi D. Lane-Cordova
Publikováno v:
Hypertension Research. 41:33-38
Blunted nocturnal dipping in blood pressure (BP) is associated with increased cardiovascular disease (CVD) risk in middle-aged/older adults. The prevalence of blunted nocturnal BP dipping is higher in persons with obesity and diabetes, conditions tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d682664363d1924ad811f2bed5d37ab
https://doi.org/10.1038/hr.2017.82
https://doi.org/10.1038/hr.2017.82
Autor:
Daniel Lindén, Andrea Ahnmark, Piero Pingitore, Ester Ciociola, Ingela Ahlstedt, Anne-Christine Andréasson, Kavitha Sasidharan, Katja Madeyski-Bengtson, Magdalena Zurek, Rosellina M. Mancina, Anna Lindblom, Mikael Bjursell, Gerhard Böttcher, Marcus Ståhlman, Mohammad Bohlooly-Y, William G. Haynes, Björn Carlsson, Mark Graham, Richard Lee, Sue Murray, Luca Valenti, Sanjay Bhanot, Peter Åkerblad, Stefano Romeo
Publikováno v:
Molecular Metabolism, Vol 22, Iss, Pp 49-61 (2019)
Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ef423fd34cee0bcaab6076b579a3a90f
https://pubmed.ncbi.nlm.nih.gov/31400373
https://pubmed.ncbi.nlm.nih.gov/31400373