Zobrazeno 1 - 10
of 84
pro vyhledávání: '"William G. Dunphy"'
Autor:
Olivier Haccard, Diletta Ciardo, Hemalatha Narrissamprakash, Odile Bronchain, Akiko Kumagai, William G. Dunphy, Arach Goldar, Kathrin Marheineke
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Metazoan genomes are duplicated by the coordinated activation of clusters of replication origins at different times during S phase, but the underlying mechanisms of this temporal program remain unclear during early development. Rif1, a key r
Externí odkaz:
https://doaj.org/article/38a0e6d91bf9464592534640dc41849f
Autor:
Yide Zhang, Binglin Shen, Tong Wu, Jerry Zhao, Joseph C. Jing, Peng Wang, Kanomi Sasaki-Capela, William G. Dunphy, David Garrett, Konstantin Maslov, Weiwei Wang, Lihong V. Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The authors introduce differentially enhanced compressed ultrafast photography, a phase imaging platform that combines high speed and sensitivity. They visualise propagation of passive current flows along myelinated axons, and electromagnetic pulses
Externí odkaz:
https://doaj.org/article/8f3fa7c3572347b4a7de2a2f22b80a84
Autor:
Akiko Kumagai, William G. Dunphy
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108178- (2020)
Summary: The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicativ
Externí odkaz:
https://doaj.org/article/b391d66e2be94512b35649cd428e68ce
Autor:
William G. Dunphy, Akiko Kumagai
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108178-(2020)
Cell reports
Cell reports
SUMMARY The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165346ae7516ccdcba73e5e2dc30ee08
https://resolver.caltech.edu/CaltechAUTHORS:20200924-091021855
https://resolver.caltech.edu/CaltechAUTHORS:20200924-091021855
Autor:
Daniel Lim, Michael B. Yaffe, Vladimir Joukov, William G. Dunphy, T. Justin Rettenmaier, Akiko Kumagai, James A. Wells
Publikováno v:
Sci Signal
Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. Our previously reported finding that protein cysteine oxidation is increased during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc84ccd37861f047ba0d8f2236115356
https://resolver.caltech.edu/CaltechAUTHORS:20200722-091504306
https://resolver.caltech.edu/CaltechAUTHORS:20200722-091504306
Autor:
Akiko Kumagai, William G. Dunphy
Publikováno v:
Molecular Biology of the Cell
MTBP, the partner of Treslin, contains a novel DNA-binding domain that associates with double-stranded DNA and G-quadruplex DNA. Mutants of MTBP that lack a functional version of this domain cannot support normal initiation of DNA replication.
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Autor:
William G. Dunphy
Publikováno v:
Molecular Cell. 81:1126-1127
Frattini et al. (2021) demonstrate that TopBP1 forms phase-separated nuclear condensates to promote activation of ATR in cells experiencing genomic stress.
Publikováno v:
Cell Cycle
Besides TopBP1, ETAA1 has been identified more recently as an activator of the ATR-ATRIP complex in human cells. We have examined the role of ETAA1 in the Xenopus egg-extract system, which has been instrumental in the study of ATR-ATRIP. Depletion of
Autor:
Cai Guo, William G. Dunphy, Anna Shevchenko, Katharina Schlacher, Andrej Shevchenko, Akiko Kumagai
Publikováno v:
Molecular Cell. 57(3):492-505
Treslin helps to trigger the initiation of DNA replication by promoting integration of Cdc45 into the replicative helicase. Treslin is a key positive-regulatory target of cell-cycle control mechanisms; activation of Treslin by cyclin-dependent kinase
Autor:
Robert Zamudio, Yaoyang Zhang, John R. Yates, Ruiling Mu, Steven I. Reed, John Tat, William G. Dunphy, Akiko Kumagai
CKS proteins are small (9-kDa) polypeptides that bind to a subset of the cyclin-dependent kinases. The two paralogs expressed in mammals, Cks1 and Cks2, share an overlapping function that is essential for early development. However, both proteins are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737ef5748b309ab990c9473bf1fa0c8
https://europepmc.org/articles/PMC5615187/
https://europepmc.org/articles/PMC5615187/