Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Autor: Jennifer Chu, Wenhan Zhang, Regina Cencic, Patrick B.F. O’Connor, Francis Robert, William G. Devine, Asher Selznick, Thomas Henkel, William C. Merrick, Lauren E. Brown, Pavel V. Baranov, John A. Porco, Jr., Jerry Pelletier

Publikováno v: Cell Reports, Vol 30, Iss 8, Pp 2481-2488.e5 (2020)

Summary: Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has been significan

Externí odkaz: https://doaj.org/article/21a67c621b25477f8f89045cf022ad46

Supplementary Data from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity

Autor: Philip J. Tofilon, Kevin Camphausen, Uma T. Shankavaram, Jerry Pelletier, William G. Devine, John A. Porco, Lauren E. Brown, Kayla Schwartz, Theresa Wechsler, Stacey L. Lehman

Supplementary Data from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad009e87a8a37538a47fbf6ff85a8fdf
https://doi.org/10.1158/1535-7163.22523721.v1

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas

Autor: John A. Porco, Yuhua Huang, Xuan Zhang, Lauren E. Brown, Kai Fu, Julie M. Vose, Ting Yue, Cheng Wang, Xinbao Hao, Tian Tian, Ting Lu, William G. Devine, Xiaoyan Zhang, Chengfeng Bi, Weiwei Zhang, Matthew A. Lunning

Publikováno v: Leukemia

MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy, and high risk of refractory disease. MYC plays a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2e588a29b83ebf10be26fa3631214
https://doi.org/10.1038/s41375-019-0503-z

Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity

Autor: Miguel Navarro, Quillon J. Simpson, Travis J. DeLano, Maria Santos Martinez-Martinez, Raquel García-Hernández, Rosario Diaz-Gonzalez, Westley Tear, Guiomar Pérez-Moreno, William G. Devine, Lori Ferrins, Dolores González-Pacanowska, Luis M. Ruiz-Pérez, Melanie G. Fritsche, Katherine M. Schneider, Michael P. Pollastri, Francisco Gamarro, John K. Fisher, Cristina Bosch-Navarrete, Pilar Manzano-Chinchon, Vivian Hilborne, Dana M. Klug, Raeann M. Dalton, Gloria Ceballos-Pérez, Eftychia M. Mavrogiannaki, Melissa J. Buskes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem

Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate- to high-risk areas for infection, current treatments are plagued by problems with safety,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419df9071d8f28b3bdefbdbcc538de7
http://hdl.handle.net/10261/246477

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites

Autor: William G. Devine, Richard J. Sciotti, Kelly A. Bachovchin, Sarah M. Thomas, Susan E. Leed, Jessey Erath, Kojo Mensa-Wilmot, Patricia J. Lee, Ana Rodriguez, Michael P. Pollastri

Publikováno v: ACS Medicinal Chemistry Letters

Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity. Previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1100b20152251c30bfb6315eb2698fd0
https://pubmed.ncbi.nlm.nih.gov/28337329