Zobrazeno 1 - 10 of 35 pro vyhledávání: '"William G. Glass"'
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Akademický článek
Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics
Autor: William G. Glass, Anna L. Duncan, Philip C. Biggin
Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2020)
Voltage-gated sodium (Nav) channels form the basis for the initiation of the action potential in excitable cells by allowing sodium ions to pass through the cell membrane. The Nav channel α subunit is known to function both with and without associat
Externí odkaz: https://doaj.org/article/35af817657a44041b2ae713f45bcc26d
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2
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms
Autor: Adamo S. Mancino, William G. Glass, Yuhao Yan, Philip C. Biggin, Derek Bowie
Publikováno v: Journal of General Physiology. 154
Alternative splicing is an important cellular mechanism that fine tunes the gating properties of both voltage- and ligand-gated ion-channels. The cardiac voltage-gated sodium channel, Nav1.5, is subject to alternative splicing of the DI S3–S4 linke
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26adaaabb14dc48392f59c5a0856d661
https://doi.org/10.1085/jgp.202112906
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3
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
Autor: Jason A. Wojcechowskyj, Marcel Meury, Dora Pinto, Exequiel Dellota, Fabio Benigni, Jesse D. Bloom, M. Alejandra Tortorici, Florian A. Lempp, Anna De Marco, Josh Dillen, Christy M. Hebner, Amin Addetia, Fabrizia Zatta, Laura E. Rosen, Elisabetta Cameroni, Nadine Czudnochowski, Amalio Telenti, Johan Neyts, Stefano Jaconi, Allison J. Greaney, Zhuoming Liu, Patrick Hernandez, John E. Bowen, Roberta Marzi, Jiayi Zhou, Maria L. Agostini, Hannah Kaiser, William G. Glass, Rana Abdelnabi, Ivy Zhang, Tristan I. Croll, Adam S. Dingens, Gyorgy Snell, Shi-Yan Caroline Foo, Davide Corti, Luca Piccoli, Martin Montiel-Ruiz, David Veesler, Sean P. J. Whelan, Gloria Lombardo, Herbert W. Virgin, Martina Beltramello, Colin Havenar-Daughton, Spencer Stumpf, Tyler N. Starr, Michael P. Housley, Jessica Bassi, John D. Chodera, Katja Culap, Nicole Sprugasci, Julia di Iulio, Chiara Silacci-Fregni, Matteo Samuele Pizzuto, Alexandra C. Walls, Young-Jun Park, Jay C. Nix, Heather Tucker
Publikováno v: Nature
Nature, vol 597, iss 7874
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape1–3, have activity against diverse sarbecoviruses4–7, and be highly protective through viral neutralization8–11 and effector functions12,13. Understanding how these properti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea33aa8d0b103b0c5bd075c01c53fa5a
https://europepmc.org/articles/PMC9282883/
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4
Coarse-Grained Molecular Dynamics Simulations of Membrane Proteins: A Practical Guide
Autor: William G, Glass, Jonathan W, Essex, Franca, Fraternali, James, Gebbie-Rayet, Irene, Marzuoli, Marley L, Samways, Philip C, Biggin, Syma, Khalid
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2302
Current computer architectures, coupled with state-of-the-art molecular dynamics simulation software, facilitate the in-depth study of large biomolecular systems at high levels of detail. However, biological phenomena take place at various time and l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::656d915d820991fc1c49ec4a28a7c2c2
https://pubmed.ncbi.nlm.nih.gov/33877632
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5
Coarse-Grained Molecular Dynamics Simulations of Membrane Proteins: A Practical Guide
Autor: Jonathan W. Essex, Irene Marzuoli, William G. Glass, Philip C. Biggin, James Gebbie-Rayet, Franca Fraternali, Marley L. Samways, Syma Khalid
Publikováno v: Methods in Molecular Biology ISBN: 9781071613931
Current computer architectures, coupled with state-of-the-art molecular dynamics simulation software, facilitate the in-depth study of large biomolecular systems at high levels of detail. However, biological phenomena take place at various time and l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6733f7251dcd46fe4f4e1647c0ce258
https://doi.org/10.1007/978-1-0716-1394-8_14
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6
COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning
Autor: Anna Carbery, Annette von Delft, Boris Kovar, Vishwanath Swamy, Ronen Gabizon, Nathan Wright, Charlie Weatherall, Susana Tomasio, Hannah E. Bruce Macdonald, Daniel Zaidmann, Ailsa Powell, P. Gehrtz, Noam Erez, Walter Ward, Vladimir Psenak, Finny S. Varghese, Edward J Griffen, Halina Mikolajek, Sharon Melamed, Emma Cattermole, A. Aimon, Elad Bar-David, Louise Dunnett, Maneesh Pingle, Warren Thompson, Efrat Resnick, William G. Glass, Mark Daniel Calmiano, J. L. Kiappes, Lizbe Koekemoer, Mariana Vaschetto, Andrew Jajack, Nir London, Martin Walsh, Beth MacLean, Charline Giroud, Haim Levy, Anastassia L. Kantsadi, Vladas Oleinikovas, Andrew Thompson, Vincent A. Voelz, Assa Sittner, Tomer Israely, John Spencer, Itai Glinert, Matthew F. D. Hurley, Richard Foster, T.J. Gorrie-Stone, Aarif Shaikh, Gijs J. Overheul, Conor Francis Wild, Michael Fairhead, Benjamin Ian Perry, David Owen, Michelle L. Hill, Peter W. Kenny, Sarma Bvnbs, Galit Cohen, Ralph P. Robinson, Jakir Pinjari, Carina Gileadi, Amir Ben-Shmuel, Shay Weiss, Victor L. Rangel, Matthew C. Robinson, Anthony Tumber, D. Fearon, Jag Paul Heer, Boaz Politi, Nicole Zitzmann, Claire Strain-Damerell, Tika R. Malla, Oleg M. Michurin, Peter K. Eastman, Christopher J. Schofield, Matthew Wittmann, Jin Pan, Eric Jnoff, Shirly Duberstein, Mihaela D. Smilova, Haim Barr, Ronald P. van Rij, Joseph E. Coffland, Garrett M. Morris, Austin Clyde, Khriesto A. Shurrush, Einat B. Vitner, Ruby Pai, Alessandro Contini, St Patrick Reid, Jose Brandao Neto, Lisa Cox, Tatiana Matviiuk, Jiye Shi, Sam Horrell, Ioannis Vakonakis, Aaron Morris, Hadeer Zidane, Juliane Brun, Yfat Yahalom-Ronen, Hadas Tamir, R. Skyner, Tobias John, John D. Chodera, Nir Paran, Alex Dias, Dominic Rufa, Willam McCorkindale, Reut Puni, Hagit Achdout, Rachael Tennant, Holly Foster, Tim Dudgeon, Bruce A. Lefker, Rambabu N. Reddi, Marian V. Gorichko, Frank von Delft, Alpha A. Lee, Milan Cvitkovic, T. Krojer, Demetri Moustakas, Oleg Fedorov, Robert C. Glen, Jason C. Cole, Petra Lukacik, Matteo P. Ferla, Melissa L Bobby, Adam Smalley, Jim Bennett, Melody Jane Morwitzer, Alice Douangamath
Herein we provide a living summary of the data generated during the COVID Moonshot project focused on the development of SARS-CoV-2 main protease (Mpro) inhibitors. Our approach uniquely combines crowdsourced medicinal chemistry insights with high th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a6fcaab3434419d1e717fb7391e5b5c
https://doi.org/10.26434/chemrxiv.13158218.v1
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7
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors
Autor: von Delft F, Ronen Gabizon, Wild Cf, Anastassia L. Kantsadi, Peter W. Kenny, Koekemoer L, Matteo P. Ferla, Noam Erez, Sharon Melamed, Adam Smalley, Gijs J. Overheul, Jag Paul Heer, Shaikh A, Tika R. Malla, R.S. Fernandes, Christopher J. Schofield, Moustakas D, Pai R, MacLean B, T. Krojer, Finny S. Varghese, Elad Bar-David, Hagit Achdout, Gregory R. Bowman, Lefker Ba, Kovar B, Charlie Weatherall, Tennant R, Griffen Ej, Yfat Yahalom-Ronen, Louise Dunnett, Emma Cattermole, Bvnbs S, Chernyshenko E, Ripka Eg, Kim Donckers, Efrat Resnick, Nir Paran, J. L. Kiappes, Einat B. Vitner, Dotson Dl, Mark Daniel Calmiano, Juliane Brun, Victor L. Rangel, Matthew F. D. Hurley, Richard Foster, Garrett M. Morris, Vaschetto M, Austin Clyde, Shay Weiss, Pan J, Nir London, William McCorkindale, Dudgeon T, Martin A. Walsh, Borden B, Haim Barr, John Spencer, Zaidmann D, Alice Douangamath, Robinson Rp, Alexandre Dias, John D. Chodera, Morris A, Marian V. Gorichko, Oleg Fedorov, V.O. Gawriljuk, Petra Lukacik, Puni R, Pinjari J, Shafeev M, Dirk Jochmans, Assa Sittner, T.J. Gorrie-Stone, White Km, Amir Ben-Shmuel, Ioannis Vakonakis, Boaz Politi, Rambabu N. Reddi, Joseph E. Coffland, Itai Glinert, Matthew C. Robinson, Ferrins L, Tomasio S, Alpha A. Lee, Khriesto A. Shurrush, Holly Foster, A. Aimon, Boby Ml, Andrea Volkamer, Alessandro Contini, Voelz, Tobias John, Galit Cohen, A.M. Nakamura, Horrell S, G.D. Noske, Jim Bennett, Oleg M. Michurin, Nicholas A. Wright, Smilova, von Delft A, Ward W, Haim Levy, Tomer Israely, Fate G, McGovern Bl, Anna Carbery, David R. Owen, Zidane H, Cox L, Michael Fairhead, Psenak, Carina Gileadi, Wittmann M, Morwitzer Mj, Solmesky Lj, Anthony Tumber, Robert C. Glen, Eric Jnoff, Reid Sp, Sukrit Singh, Steven De Jonghe, Claire Strain-Damerell, Jason C. Cole, A.J. Powell, Rosales R, Nicole Zitzmann, D. Fearon, Nguyen L, Rodriguez-Guerra J, Shirly Duberstein, Andrew Thompson, Johan Neyts, Benjamin Ian Perry, van Rij Rp, Jose Brandao Neto, William G. Glass, Rufa D, Charline Giroud, Peter Eastman, Hannah E. Bruce Macdonald, Glaucius Oliva, Mark A. Hill, Laura Vangeel, Jiye Shi, Hadas Tamir, R. Skyner, Mikolajek H, Adolfo García-Sastre, Oleinikovas, Pingle M, Henry M, Cvitkovic M, Milne Bf, Hart Sh, Eyermann Cj, Thompson W, Matviiuk T, Andre S. Godoy, Swamy, P. Gehrtz, Jajack A
The COVID-19 pandemic was a stark reminder that a barren global antiviral pipeline has grave humanitarian consequences. Pandemics could be prevented in principle by accessible, easily deployable broad-spectrum oral antivirals. Here we report the resu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::378b6d7608ebe4f22cf964ef3c0dad99
https://doi.org/10.1101/2020.10.29.339317
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8
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Autor: Jitske Jansen, Katharina C. Reimer, James S. Nagai, Finny S. Varghese, Gijs J. Overheul, Marit de Beer, Rona Roverts, Deniz Daviran, Liline A.S. Fermin, Brigith Willemsen, Marcel Beukenboom, Sonja Djudjaj, Saskia von Stillfried, Larissa E. van Eijk, Mirjam Mastik, Marian Bulthuis, Wilfred den Dunnen, Harry van Goor, Jan-Luuk Hillebrands, Sergio H. Triana, Theodore Alexandrov, Marie-Cherelle Timm, Bartholomeus T. van den Berge, Martijn van den Broek, Quincy Nlandu, Joelle Heijnert, Eric M.J. Bindels, Remco M. Hoogenboezem, Fieke Mooren, Christoph Kuppe, Pascal Miesen, Katrien Grünberg, Ties Ijzermans, Eric J. Steenbergen, Jan Czogalla, Michiel F. Schreuder, Nico Sommerdijk, Anat Akiva, Peter Boor, Victor G. Puelles, Jürgen Floege, Tobias B. Huber, Ronald P. van Rij, Ivan G. Costa, Rebekka K. Schneider, Bart Smeets, Rafael Kramann, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Emma Cattermole, Eugene Chernychenko, John D. Choder, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alica Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Federov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, null Itai glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Micheal Henry, Michelle Hill, Sam Horrell, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J.L. Kiappes, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha A. Lee, Bruce A. Lefker, Haim Levy, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth Maclean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garret M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, David Owen, Vladimir Psenak, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Reut Puni, Victor L. Rangel, Ranbabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Sing, Assa Sittner, Rachael Skyner, Adam Smalley, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damarell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Susana Tomasia, Anthony Tumber, Ioannis Vakonakis, Laura van Geel, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andra Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
Publikováno v: Cell Stem Cell, 29, 217-231
Cell Stem Cell, 29(2), 217-231.e8. Cell Press
Cell stem cell, 29(2), 217-231.e8. CELL PRESS
Cell Stem Cell, 29, 2, pp. 217-231
Cell Stem Cell
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30090579eb88d0c8a1271dff5c588354
http://www.scopus.com/inward/record.url?scp=85123016842&partnerID=8YFLogxK
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10
IL-10 is pathogenic during the development of coxsackievirus B4-induced chronic pancreatitis
Autor: Andrew A. Reilly, Rui Gu, Anae Shampang, Arlene I. Ramsingh, Dusti Fisher, William G. Glass
Publikováno v: Virology. 395(1):77-86
Using a mouse model of coxsackievirus B4 (CVB4-V)-induced chronic pancreatitis, we investigated whether cytokines are involved in the progression of acute disease to chronic inflammatory disease. We show that IL-10 contributed to the development of c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0316a2b22a96fa6a559c842d2c334ea
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