Zobrazeno 1 - 10
of 76
pro vyhledávání: '"William G Kramer"'
Autor:
Michael R. Hodges, Eric Ople, Pamela Wedel, Karen J. Shaw, Abhijeet Jakate, William G. Kramer, Sjoerd van Marle, Ewoud-Jan van Hoogdalem, Margaret Tawadrous
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Fosmanogepix (FMGX, APX001), a first-in-class, intravenous (i.v.) and oral (p.o.) antifungal prodrug candidate is currently in clinical development for the treatment of invasive fungal infections. Manogepix (MGX, APX001A), the active moiety of FMGX,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8519ae4f2f641b726b374191c2ec7bea
https://doi.org/10.1128/aac.01623-22
https://doi.org/10.1128/aac.01623-22
Publikováno v:
Clinical Kidney Journal
Background Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is an oral potassium binder for the treatment of hyperkalemia in adults. SZC acts in the gastrointestinal tract and additionally binds hydrogen ions in acidic environments like the stomac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe8bd1779164cba5c66e72ec2ffb363
http://europepmc.org/articles/PMC8243284
http://europepmc.org/articles/PMC8243284
Autor:
Sidney L Weiss, William G. Kramer
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics
Purpose: Evaluate the ocular distribution, tolerability, and systemic exposure of cyclosporine (CsA) in New Zealand white rabbits following topical administration of OTX-101, a novel, clear aqueous nanomicellar solution developed for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe45a9e25eec42322a79b8b0e3b38f4
https://doi.org/10.1089/jop.2018.0106
https://doi.org/10.1089/jop.2018.0106
Autor:
Eric Lang, Peter G. Lacouture, Douglas A. Hamilton, William G. Kramer, Edward Liao, Cynthia C. Ernst, Atulkumar Ramaiya, Donna Madden, Daniel B. Carr
Publikováno v:
Clinical Pharmacology in Drug Development
Given their established analgesic properties, nonsteroidal anti‐inflammatory drugs (NSAIDs) represent an important postoperative pain management option. This study investigated: (1) the effects of mild or moderate renal insufficiency and mild hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb44e49f2ff12334a3f8f9769303097
https://doi.org/10.1002/cpdd.417
https://doi.org/10.1002/cpdd.417
Autor:
William G. Kramer, Julie Krop
Publikováno v:
Clinical Therapeutics. 39:2345-2354
Purpose The purpose of this study was to evaluate the bioavailability of hydroxyprogesterone caproate (HPC) administered as a subcutaneous injection in the back of the upper arm using a prefilled autoinjector syringe with a 27-gauge needle compared w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460cd0adf0c78121b58605805c9f7350
https://doi.org/10.1016/j.clinthera.2017.10.020
https://doi.org/10.1016/j.clinthera.2017.10.020
Autor:
Angela Justice, Sidney L Weiss, Josh Johnston, David G Evans, Paul M. Karpecki, Doug Devries, Abayomi Ogundele, April L Jasper, William G Kramer, Patrick O'Connor
Publikováno v:
Clinical Ophthalmology (Auckland, N.Z.)
Paul M Karpecki,1,2 Sidney L Weiss,3 William G Kramer,4 Patrick O’Connor,5 David Evans,6 Josh Johnston,7 April L Jasper,8 Angela Justice,9 Abayomi B Ogundele,9 Doug Devries10 1Kentucky Eye Institute, Lexington, KY, USA; 2Gaddie Eye Centers, Louisvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb248e873076d22e5075b3fa27a7602
https://pubmed.ncbi.nlm.nih.gov/31040639
https://pubmed.ncbi.nlm.nih.gov/31040639
Publikováno v:
Clinical Pharmacology : Advances and Applications
Neha Parikh,1 William G Kramer,2 Varun Khurana,1 Christina Cognata Smith,1 Santosh Vetticaden,1 1INSYS Therapeutics, Inc., Chandler, AZ, USA; 2Kramer Consulting LLC, North Potomac, MD, USA Background: Dronabinol, a pharmaceutical Δ-9-tetrahydrocanna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a5a7caf4f973d8e0ec65e809da66f7
https://doi.org/10.2147/cpaa.s115679
https://doi.org/10.2147/cpaa.s115679
Autor:
Daniel Dickerson, Eric P. Hoffman, Jesse M. Damsker, Miroslav Backonja, John M. McCall, Valerie Riddle, William G. Kramer, Heather Gordish-Dressman, Kanneboyina Nagaraju, Maxime A. Siegler
Publikováno v:
Steroids
Background Glucocorticoid drugs are highly effective anti-inflammatory agents, but chronic use is associated with extensive pharmacodynamic safety concerns that have a considerable negative impact on patient quality of life. Purpose Vamorolone (VBP15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6ffbabdddde709bb90032ce3ab288c
https://europepmc.org/articles/PMC6136660/
https://europepmc.org/articles/PMC6136660/
Publikováno v:
Journal of Clinical Pharmacology
In bioequivalence (BE) testing, it is the convention to identify tlast separately for each concentration‐vs‐time profile. Within‐subject differences in tlast between treatments can arise when assay sensitivity is reached during washout, causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89b95f3150f1e553b15bdebea55cc10
http://europepmc.org/articles/PMC5064724
http://europepmc.org/articles/PMC5064724
Publikováno v:
The Journal of Clinical Pharmacology. 55:1004-1011
Tasimelteon ([1R-trans]-N-[(2-[2,3-dihydro-4-benzofuranyl] cyclopropyl) methyl] propanamide), a novel dual melatonin receptor agonist that demonstrates specificity and high affinity for melatonin receptor types 1 and 2 (MT1 and MT2 receptors), is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb3f17619f74f13d9670f778c5ee2ea
https://doi.org/10.1002/jcph.507
https://doi.org/10.1002/jcph.507