Zobrazeno 1 - 10
of 122
pro vyhledávání: '"William G Kerr"'
Autor:
Rajesh Somasundaram, Sandra Fernandes, Jasper J Deuring, Colin de Haar, Ernst J Kuipers, Lauran Vogelaar, Frank A Middleton, C Janneke van der Woude, Maikel P Peppelenbosch, William G Kerr, Gwenny M Fuhler
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182308 (2017)
SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytok
Externí odkaz:
https://doaj.org/article/438601c795fd434ca47b09f3b310e90a
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3565 (2008)
The SH2-containing-5'inositol phosphatase-1 (SHIP) influences signals downstream of cytokine/chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1/CXCL-12 and interleukin-3. We hypothesi
Externí odkaz:
https://doaj.org/article/c11661b05fa3438588b2a69428d0c924
Autor:
Shea T. Meyer, Sandra Fernandes, Robert E. Anderson, Angela Pacherille, Bonnie Toms, William G. Kerr, John D. Chisholm
Publikováno v:
Molecules, Vol 28, Iss 24, p 8048 (2023)
The SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) enzyme opposes the activity of PI3K and therefore is of interest in the treatment of inflammatory disorders. Recent results also indicate that SHIP1 promotes phagolysosomal degradation
Externí odkaz:
https://doaj.org/article/9a098d6bb6124f6f9847d93c7e2ed081
Autor:
Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Raki Sudan, Elizabeth A. Luke, Otto M. Dungan, Angela Pacherille, Shea T. Meyer, Shawn Dormann, Stéphane Schurmans, Benedict J. Chambers, John D. Chisholm, William G. Kerr
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106071- (2023)
Summary: Here we extend the understanding of how chemical inhibition of SHIP paralogs controls obesity. We compare different classes of SHIP inhibitors and find that selective inhibitors of SHIP1 or SHIP2 are unable to prevent weight gain and body fa
Externí odkaz:
https://doaj.org/article/193eb622fd5540ccb7390064bb00037e
Autor:
Raki Sudan, Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Shea T. Meyer, John D. Chisholm, Robert W. Engelman, William G. Kerr
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Humans homozygous for inactivating LRBA (lipopolysaccharide (LPS)-responsive beige-like anchor) mutations or with compound heterozygous mutations exhibit a spectrum of immune-related pathologies including inflammatory bowel disease (IBD). The cause o
Externí odkaz:
https://doaj.org/article/d24cd901c8a64d47832a28c49875040d
Autor:
Sandra Fernandes, Shea T. Meyer, Jigisha P. Shah, Arijit A. Adhikari, William G. Kerr, John D. Chisholm
Publikováno v:
Molecules, Vol 27, Iss 23, p 8451 (2022)
Inhibition of phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP) with small molecule inhibitors leads to apoptosis in tumor cells. Inhibitors that target both SHIP1 and SHIP2 (pan-SHIP1/2 inhibitors) may have benefits in these areas since
Externí odkaz:
https://doaj.org/article/87b28e05614c417d8cd52919f29322aa
Autor:
Sandra Fernandes-Denney, William G. Kerr, Brian C. Duffy, Otto M. Dungan, Daniel Effiong, Shawn Dormann, John D. Chisholm
Publikováno v:
Org Biomol Chem
AQX-1125 is an indane based SHIP1 agonist that has been evaluated in the clinic for the treatment of bladder pain syndrome/interstitial cystitis. To support our own studies on SHIP1 agonists as potential treatments for IBD and Crohn's disease, a new
Publikováno v:
FASEB J
Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155, a pro-inflammatory factor. Deletion of the SHIP-1 gene in mice caused spontaneous lung inflammation and fibrosis. However, the role and function of endothelial miR-155
Autor:
Chiara Pedicone, Sandra Fernandes, Alessandro Matera, Shea T. Meyer, Stewart Loh, Jeung-Hoi Ha, Denzil Bernard, John D. Chisholm, Rosa Chiara Paolicelli, William G. Kerr
Publikováno v:
iScience. 25(4)
Here, we describe the use of artificial intelligence to identify novel agonists of the SH2-containing 5' inositol phosphatase 1 (SHIP1). One of the compounds, K306, represents the most potent agonist identified to date. We find that K306 exhibits sel
Autor:
Fengrui Zhang, Xujun Ye, Zhou Zhu, Lihui Wang, Haiying Tang, Li Zhou, Tao Zheng, William G. Kerr, Zi Chen, Li Zhang, Yadong Wei
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP-1) regulates the intracellular levels of phosphotidylinositol-3, 4, 5-trisphosphate, a phosphoinositide 3–kinase (PI3K) product. Emerging evidence suggests that the PI3K pathway is i