Zobrazeno 1 - 10
of 51
pro vyhledávání: '"William G, Walton"'
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Samuel J. Pellock, Benjamin C. Creekmore, William G. Walton, Naimee Mehta, Kristen A. Biernat, Andrew P. Cesmat, Yamuna Ariyarathna, Zachary D. Dunn, Bo Li, Jian Jin, Lindsey I. James, Matthew R. Redinbo
Publikováno v:
ACS Central Science, Vol 4, Iss 7, Pp 868-879 (2018)
Externí odkaz:
https://doaj.org/article/b1ff0ac7279e4be986216bba4649e130
Autor:
Tongde Wu, Julianne Huang, Patrick J. Moore, Michael S. Little, William G. Walton, Robert C. Fellner, Neil E. Alexis, Y. Peter Di, Matthew R. Redinbo, Stephen L. Tilley, Robert Tarran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the
Externí odkaz:
https://doaj.org/article/c13d74cd6193402c97012e807c2d9c19
Autor:
Benjamin C. Creekmore, Josh H. Gray, William G. Walton, Kristen A. Biernat, Michael S. Little, Yongmei Xu, Jian Liu, Raad Z. Gharaibeh, Matthew R. Redinbo
Publikováno v:
mSystems, Vol 4, Iss 4 (2019)
ABSTRACT Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human M
Externí odkaz:
https://doaj.org/article/b1c52767175148238815600a394ac356
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203621 (2018)
SPLUNC1 is a multifunctional protein of the airway with antimicrobial properties. We previously reported that it displayed antibiofilm activities against P. aeruginosa. The goal of this study was to determine whether (1) the antibiofilm property is b
Externí odkaz:
https://doaj.org/article/30238aa73dd645489098a86c20b01ddb
Autor:
Pierre Jacob, Li Wan, Korina Kempthorn, William G. Walton, Zhen-Ming Pei, Matthew R. Redinbo, Adam D. Lietzan, Nak Hyun Kim, Farid El-Kasmi, Jeffery L. Dangl, Fei-Hua Wu, Oliver J. Furzer, Yuan Chi, Sruthi Sunil
Publikováno v:
Science. 373:420-425
Calcium signaling for host cell death In response to microbial pathogens, some plants kill off their own cells to limit further spread of infection. The Toll/Interleukin-1 receptor/Resistance class of nucleotide-binding leucine-rich repeat receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::489dd133253b1fe68ae529993c384d1c
https://doi.org/10.1126/science.abg7917
https://doi.org/10.1126/science.abg7917
Autor:
Benjamin C. Creekmore, Jeffrey Roach, Raad Z. Gharaibeh, M. Andrea Azcarate-Peril, William G. Walton, Ian D. Wilson, Matthew R. Redinbo, Jonathan R. Swann, R. Balfour Sartor, S.J. Pellock, Aadra P. Bhatt, Bret D. Wallace, Jose R. Roques, David B. Darr, Scott J. Bultman, Marine P.M. Letertre, Sean T. Bailey, Stephanie A. Montgomery, Kristen A. Biernat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cancer chemotherapy often causes side effects that require modulations in dosing, which then reduce anticancer efficacy. Here, we show that targeted inhibition of gut bacterial enzymes alleviates key stages of gut epithelial damage cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93892ba246e6d26c5938d33d034add6d
http://europepmc.org/articles/PMC7132129
http://europepmc.org/articles/PMC7132129
Autor:
Jonathan M, Conway, William G, Walton, Isai, Salas-González, Theresa F, Law, Chloe A, Lindberg, Laura E, Crook, Suzanne M, Kosina, Connor R, Fitzpatrick, Adam D, Lietzan, Trent R, Northen, Corbin D, Jones, Omri M, Finkel, Matthew R, Redinbo, Jeffery L, Dangl
Publikováno v:
Nature microbiology. 7(11)
Chemical signalling in the plant microbiome can have drastic effects on microbial community structure, and on host growth and development. Previously, we demonstrated that the auxin metabolic signal interference performed by the bacterial genus Vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1b971e96a176f1336e0231af2380ab7
https://pubmed.ncbi.nlm.nih.gov/36266335
https://pubmed.ncbi.nlm.nih.gov/36266335
Autor:
Bayarchimeg Mashbat, Evangelos Bellos, Stephanie Hodeib, Fadil Bidmos, Ryan S Thwaites, Yaxuan Lu, Victoria J Wright, Jethro A Herberg, Daniela S Klobassa, William G Walton, Werner Zenz, Trevor T Hansel, Simon Nadel, Paul R Langford, Luregn J Schlapbach, Ming-Shi Li, Matthew R Redinbo, Y Peter Di, Michael Levin, Vanessa Sancho-Shimizu
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Neisseria meningitidis (Nm) is a nasopharyngeal commensal carried by healthy individuals. However, invasive infections occurs in a minority of individuals, with devastating consequences. There is evidence that common polymorphisms are asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a4936390cffc2158502f6423cad364
https://doi.org/10.1093/cid/ciz600
https://doi.org/10.1093/cid/ciz600
Autor:
S.J. Pellock, Lianjie Wei, Andrew P. Cesmat, Matthew R. Redinbo, William G. Walton, Dorothy A. Erie, Bich Ngoc T. Tran, Marissa M. Bivins, Michael C. Snider, Ashutosh Tripathy, Aadra P. Bhatt, Kristen A. Biernat
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Bacterial β-glucuronidase (GUS) enzymes cause drug toxicity by reversing Phase II glucuronidation in the gastrointestinal tract. While many human gut microbial GUS enzymes have been examined with model glucuronide substrates like p-nitrophenol-β-D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d0a09c0c2f9611457c2fa2554c33f0
http://link.springer.com/article/10.1038/s41598-018-36069-w
http://link.springer.com/article/10.1038/s41598-018-36069-w