Výsledky vyhledávání - "William G, Tracewell"

Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagement

Autor: Michelle Mellion, Sander Brooks, Diego Cadavid, Shane Raines, Michelle Hage, Geert Jan Groeneveld, Cécile Berends, William G Tracewell, Adefowope Odueyungbo, Lorin A. Thompson, Lucienne Ronco, Michiel J van Esdonk, Lisa Pagan, Umesh A. Badrising, Emilie M J van Brummelen, Baziel G.M. van Engelen

Publikováno v: British Journal of Clinical Pharmacology, 87(12), 4658-4669. WILEY

Aims Evaluate safety, tolerability, pharmacokinetics (PK) and target engagement (TE) of losmapimod in blood and muscle in facioscapulohumeral dystrophy (FSHD). Methods This study included Part A: 10 healthy volunteers randomized to single oral doses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc884dc6eac870563f6d4cc46fe9b44f
http://hdl.handle.net/1887/3248780

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Pharmacokinetics, metabolism and safety of deuterated L-DOPA (SD-1077)/carbidopa compared to L-DOPA/carbidopa following single oral dose administration in healthy subjects

Autor: Frank, Schneider, Lavi, Erisson, Hooman, Beygi, Margaret, Bradbury, Orit, Cohen-Barak, Igor D, Grachev, Serge, Guzy, Pippa S, Loupe, Micha, Levi, Mirna, McDonald, Juha-Matti, Savola, Spyros, Papapetropoulos, William G, Tracewell, Maria, Velinova, Ofer, Spiegelstein

Publikováno v: British journal of clinical pharmacology. 84(10)

SD-1077, a selectively deuterated precursor of dopamine (DA) structurally related to L-3,4-dihydroxyphenylalanine (L-DOPA), is under development for treatment of motor symptoms of Parkinson's disease. Preclinical models have shown slower metabolism o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a79b98d8baa7e8ab3ceb6e5e17bd386f
https://pubmed.ncbi.nlm.nih.gov/29959802

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Effects of Chlorophyll and Chlorophyllin on Low-Dose Aflatoxin B1 Pharmacokinetics in Human Volunteers

Autor: Carole Jubert, George S. Bailey, William G. Tracewell, Kenneth W. Turteltaub, Cliff Pereira, Roderick H. Dashwood, John E. Mata, Graham Bench, David E. Williams

Publikováno v: Cancer Prevention Research. 2:1015-1022

Chlorophyll (Chla) and chlorophyllin (CHL) were shown previously to reduce carcinogen bioavailability, biomarker damage, and tumorigenicity in trout and rats. These findings were partially extended to humans, where CHL reduced excretion of aflatoxin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe9a068fbae9c3b4ef1c5a32b4074c8
https://doi.org/10.1158/1940-6207.capr-09-0099

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Pharmacokinetics and Bioavailability of Aerosolized Tobramycin in Cystic Fibrosis

Autor: Bonnie W. Ramsey, William H. Pitlick, Pasqua A. Nardella, William G. Tracewell, David E. Geller

Publikováno v: Chest. 122:219-226

Study objectives To describe the pharmacokinetics and bioavailability of inhaled tobramycin (TOBI; Chiron Corporation; Seattle, WA), 300-mg dose, delivered by a nebulizer (PARI LC Plus; Pari Respiratory; Richmond, VA) and a compressor (Pulmo-Aide, mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7d746ee812bef8547bad43d3830ee3
https://doi.org/10.1378/chest.122.1.219

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Effect of a high-fat meal on thalidomide pharmacokinetics and the relative bioavailability of oral formulations in healthy men and women

Autor: Karin A. Kook, William G. Tracewell, David I. Stirling, Steve D. Thomas, Steve K. Teo, Michael R. Scheffler, Wayne A. Colburn

Publikováno v: Biopharmaceutics & Drug Disposition. 21:33-40

The effect of food on the oral pharmacokinetics of thalidomide and the relative bioavailability of two oral thalidomide formulations were determined in an open label, single dose, randomized, three-way crossover study. Five male and eight female heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ffcb6becfab82a47683a2902f28d3ea
https://doi.org/10.1002/1099-081x(200001)21:1<33::aid-bdd213>3.0.co

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Pharmacokinetics and Pharmacodynamics of Hydroxyurea

Autor: William G. Tracewell, Peter R. Gwilt

Publikováno v: Clinical Pharmacokinetics. 34:347-358

Hydroxyurea is used in the treatment of various forms of cancer, sickle-cell anaemia and HIV infection. Oral absorption of the drug is virtually complete, the volume of distribution is equivalent to total body water and elimination is through both re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e174c4f8786c17ee6580038f21a8fdc7
https://doi.org/10.2165/00003088-199834050-00002

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Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Autor: John E. Mata, Jennifer M. Simpson, Bernard Séguin, Kevin Marley, William G. Tracewell, Stuart C. Helfand, Shay Bracha, Lisa Brownlee

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR

Background Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e4af0ae573f774ddd1cc0f67438ca6
https://doi.org/10.1186/1756-9966-32-74

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Effect of colesevelam on lovastatin pharmacokinetics

Autor: Joanne M. Donovan, Mark R. Stiles, James C Kisicki, William G Tracewell, Steven K. Burke

Publikováno v: The Annals of pharmacotherapy. 36(3)

OBJECTIVE:To assess potential interactions of colesevelam hydrochloride and lovastatin in healthy volunteers when lovastatin alone was administered with dinner, both lovastatin and colesevelam were administered with dinner, and colesevelam was admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd62a744028f37ad572205e70de273f
https://pubmed.ncbi.nlm.nih.gov/11895049

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Pharmacokinetics and in vivo effects of a six-base phosphorothioate oligodeoxynucleotide with anticancer and hematopoietic activities in swine

Autor: John D. Jackson, John E. Mata, Shantaram S. Joshi, William G. Tracewell, Samuel J. Pirruccello, Barbara J. Murphy, Michael R. Bishop, Patrick L. Iversen

Publikováno v: Journal of hematotherapystem cell research. 9(2)

A short phosphorothioate oligodeoxynucleotide telomere mimic with the sequence 5'-d(TTAGGG)-3', TAG-6, has been shown to inhibit telomerase activity and have antineoplastic and hematopoietic stimulatory properties. In this study, three immature male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3f1225431dc82a79e24d00457c7a45
https://pubmed.ncbi.nlm.nih.gov/10813533

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Population pharmacokinetics of hydroxyurea in cancer patients

Autor: Peter R. Gwilt, William P. Vaughan, William G. Tracewell, Donald L. Trump, David C. Smith

Publikováno v: Cancer chemotherapy and pharmacology. 35(5)

The pharmacokinetics of hydroxyurea (HU) were investigated in cancer patients after intravenous infusion or oral administration. On the basis of the minimal value of the objective function (MVOF) and prior knowledge of the disposition of HU in animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d671f9bf2d10033a2da391bd2e75e7
https://pubmed.ncbi.nlm.nih.gov/7850924

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