Zobrazeno 1 - 10
of 18
pro vyhledávání: '"William G, Bernard"'
Autor:
Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 165-179 (2019)
Summary: Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these interplays at the molecular level remains challenging due to the lack of efficient methods allowing cell c
Externí odkaz:
https://doaj.org/article/1845b195505f44a78af9a9414bb07768
Autor:
Lay Ping Ong, Johannes Bargehr, Vincent R. Knight-Schrijver, Jonathan Lee, Maria Colzani, Semih Bayraktar, William G. Bernard, Silvia Marchiano, Alessandro Bertero, Charles E. Murry, Laure Gambardella, Sanjay Sinha
Ischemic heart failure is due to irreversible loss of cardiomyocytes. Preclinical studies showed that human pluripotent stem cell (hPSC)-derived cardiomyocytes could remuscularize infarcted hearts and improve cardiac function. However, these cardiomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720d1ce9eb3dd40eef88d734ab4e3771
https://hdl.handle.net/2318/1898773
https://hdl.handle.net/2318/1898773
Autor:
Berthold Göttgens, Vincent Knight-Schrijver, Sophie McManus, Maura A. Morrison, Laure Gambardella, Sanjay Sinha, William G. Bernard, Paul R. Riley, Agathe Delaune, Victoria Moignard, Nicholas Le Novère, Derya Sebukhan
Publikováno v:
Journal of Molecular and Cellular Cardiology. 140:30-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdc290cfddce6b8a7c9c554a27cd478
https://doi.org/10.1016/j.yjmcc.2019.11.071
https://doi.org/10.1016/j.yjmcc.2019.11.071
Autor:
Simon Andrews, Sanjay Sinha, Victoria Moignard, Sophie McManus, Berthold Göttgens, Paul R. Riley, Maura A. Morrison, Laure Gambardella, Derya Sebukhan, William G. Bernard, Nicolas Le Novère, Agathe Delaune
Publikováno v:
Development (Cambridge, England)
The murine developing epicardium heterogeneously expresses the transcription factors TCF21 and WT1. Here, we show that this cell heterogeneity is conserved in human epicardium, regulated by BNC1 and associated with cell fate and function. Single cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681767971f55fce640b11d10dc608ac
https://ora.ox.ac.uk/objects/uuid:57faa466-1682-42f3-8fed-f2fb99f7e078
https://ora.ox.ac.uk/objects/uuid:57faa466-1682-42f3-8fed-f2fb99f7e078
Autor:
William G. Bernard, Nichola Figg, Amy M. Martinson, Laure Gambardella, Shiv Bhandari, Dharini Iyer, Hongorzul Davaapil, Johannes Bargehr, Michael Regnier, Sanjay Sinha, Nicolas Le Novère, Andrea Leonard, Charles E. Murry, Peter Hofsteen, Fotios Sampaziotis, Alessandro Bertero, Florian Weinberger, Maria Colzani, Martin R. Bennett, L. Ong
Publikováno v:
Nature biotechnology
The epicardium and its derivatives provide trophic and structural support for the developing and adult heart. Here we tested the ability of human embryonic stem cell (hESC)-derived epicardium to augment the structure and function of engineered heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7bd773cb689a144f919e8a98a7c388
https://www.repository.cam.ac.uk/handle/1810/292922
https://www.repository.cam.ac.uk/handle/1810/292922
Autor:
Anthony P. Davenport, Sanjay Sinha, Rhoda E. Kuc, William G. Bernard, Janet J. Maguire, Thomas Williams, Robyn Macrae, Maria Colzani, Duuamene Nyimanu
Publikováno v:
Basic Science.
Introduction The apelin receptor is expressed throughout the cardiovascular system, including in cardiomyocytes. Receptor activation by either of its endogenous peptide ligands, apelin or Elabela, has a positive inotropic effect and promotes vasodila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c8593188d5e3c4890d16fcc2867c48
https://doi.org/10.1136/heartjnl-2019-bcs.210
https://doi.org/10.1136/heartjnl-2019-bcs.210
Autor:
L. Ong, Nichola Figg, Sanjay Sinha, M. Martinson, Shiv Bhandari, Dharini Iyer, Laure Gambardella, William G. Bernard, Martin R. Bennett, F. Weinberger, Peter Hofsteen, Fotios Sampaziotis, Charles E. Murry, Johannes Bargehr
Publikováno v:
European Heart Journal. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf2bd9b124d443aa74f0012a66caa50d
https://doi.org/10.1093/eurheartj/ehx493.5728
https://doi.org/10.1093/eurheartj/ehx493.5728
Publikováno v:
British Journal of Pharmacology. 169:1624-1634
Background and Purpose Histamine and prostaglandin E2 (PGE2), directly and via their effects on other cells, regulate the behaviour of vascular smooth muscle (VSM), but their effects on human VSM are incompletely resolved. Experimental Approach The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6eb1c1f0749a9e4c2a819ae778b09a0
https://doi.org/10.1111/bph.12239
https://doi.org/10.1111/bph.12239
Autor:
Priya Sastry, Sanjay Sinha, Madeline McNamara, Alessandra Granata, Felipe Serrano, Lucinda Low, William G. Bernard
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1. To investigate the pathogenesis of aortic aneurysms in MFS, we generated a vascular model derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b7f6e5565ce274714b28c0d1300cd4
Autor:
Lucinda Low, William G. Bernard, Johannes Bargehr, Martin R. Bennett, Christine Cheung, Sanjay Sinha, Laure Gambardella, Dharini Iyer
Vascular smooth muscle cells (SMCs) from distinct anatomic locations derive from different embryonic origins. Here we investigated the respective potential of different embryonic origin-specific SMCs derived from human embryonic stem cells (hESCs) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efc08887c194cf2dfcea41092f9deae
https://europepmc.org/articles/PMC4922852/
https://europepmc.org/articles/PMC4922852/