Výsledky vyhledávání - "William G, Allard"

Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data

Autor: Inger Johansson, Renee Baak-Pablo, Birgit A. L. M. Deiman, William G. Allard, Maaike van der Lee, Patrick Neven, Magnus Ingelman-Sundberg, Henk-Jan Guchelaar, Rolf H. A. M. Vossen, Jesse J. Swen, Maarten J. Deenen, Seyed Yahya Anvar, Roberta Menafra, Stefano Gastaldello

Publikováno v: Science Translational Medicine, 13(603). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 13(603):eabf3637. American Association for the Advancement of Science (AAAS)
Science Translational Medicine

Pharmacogenomics is a key component of personalized medicine that promises safer and more effective drug treatment by individualizing drug choice and dose based on genetic profiles. In clinical practice, genetic biomarkers are used to categorize pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0664d95ca1b3b663344e2cce145d90
https://hdl.handle.net/1887/3209082

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Toward predicting CYP2D6-mediated variable drug response from

Autor: Maaike, van der Lee, William G, Allard, Rolf H A M, Vossen, Renée F, Baak-Pablo, Roberta, Menafra, Birgit A L M, Deiman, Maarten J, Deenen, Patrick, Neven, Inger, Johansson, Stefano, Gastaldello, Magnus, Ingelman-Sundberg, Henk-Jan, Guchelaar, Jesse J, Swen, Seyed Yahya, Anvar

Publikováno v: Science translational medicine. 13(603)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce1cead6364dedef1d524ac7d00d9d56
https://pubmed.ncbi.nlm.nih.gov/34290055

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A unifying model to predict variable drug response for personalised medicine

Autor: Maarten J. Deenen, William G. Allard, Birgit A. L. M. Deiman, Renee Baak-Pablo, Rolf H. A. M. Vossen, Henk-Jan Guchelaar, Maaike van der Lee, Patrick Neven, Inger Johansson, Roberta Menafra, Magnus Ingelman-Sundberg, Jesse J. Swen, Seyed Yahya Anvar, Stefano Gastaldello

Pharmacogenomics is a key component of personalized medicine. It promises a safer and more effective drug treatment by individualizing the choice of drug and dose based on an individual’s genetic profile1,2. The majority of commonly prescribed drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e222f5dd2a9de910514e1a370eab5b

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Repurposing of Diagnostic Whole Exome Sequencing Data of 1,583 Individuals for Clinical Pharmacogenetics

Autor: Henk-Jan Guchelaar, Mariëtte J.V. Hoffer, Maaike van der Lee, Claudia A. L. Ruivenkamp, Sander Bollen, Marjolein Kriek, Gijs W. E. Santen, William G. Allard, Seyed Y Anvar, Jesse J. Swen

Publikováno v: Clinical Pharmacology and Therapeutics, 107, 3, pp. 617-627
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 107, 617-627
Clinical Pharmacology and Therapeutics. WILEY
Clinical Pharmacology & Therapeutics

Contains fulltext : 229047.pdf (Publisher’s version ) (Open Access) For ~ 80 drugs, widely recognized pharmacogenetics dosing guidelines are available. However, the use of these guidelines in clinical practice remains limited as only a fraction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b5d7848da038b11f77b0d6a34c091d
https://hdl.handle.net/2066/229047

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Flexible and Scalable Full‐Length CYP2D6 Long Amplicon PacBio Sequencing

Autor: Seyed Yahya Anvar, Henk P. J. Buermans, Henk-Jan Guchelaar, Rolf H. A. M. Vossen, Johan T. den Dunnen, William G. Allard, Tahar van der Straaten, Stefan J. White, Jesse J. Swen

Publikováno v: Human Mutation
Human Mutation, 38(3), 310-316

Cytochrome P450 2D6 (CYP2D6) is among the most important genes involved in drug metabolism. Specific variants are associated with changes in the enzyme's amount and activity. Multiple technologies exist to determine these variants, like the AmpliChip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ee17656a50a1ab9345b6ace8754fe1
http://europepmc.org/articles/PMC5324676

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