Zobrazeno 1 - 8
of 8
pro vyhledávání: '"William Francis Heath"'
Autor:
Lawrence M. Ballas, David Andrew Neel, Steven E. Hall, Matthew Baevsky, William Francis Heath, Stramm Lawrence E, Anita Melikian-Badalian, Michael R. Jirousek, Christopher John Rito, Upinder Singh, Cecile M. Gonzalez, Leonard L. Winneroski, Margaret M. Faul, Gillig James Ronald, John H. McDonald
Publikováno v:
Journal of Medicinal Chemistry. 39:2664-2671
Protein kinase C (PKC) is a family of closely related serine and threonine kinases. Overactivation of some PKC isozymes has been postulated to occur in several diseases states, including diabetic complications. Selective inhibition of overactivated P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69817961f6ca869303465bb56dacbef8
https://doi.org/10.1021/jm950588y
https://doi.org/10.1021/jm950588y
Autor:
Michael R. Jirousek, Margaret M. Faul, Steven E. Hall, Douglas D. O'Bannon, John H. McDonald, Leonard L. Winneroski, William Francis Heath, David Andrew Neel, Christopher John Rito, Anita Melikian-Badalian, Matthew Baevsky, Gillig James Ronald, Larwence M Ballas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2093-2096
The synthesis of a novel class of N-N′-macrocyclic bisindolylmaleimides is reported. The key step involves a remarkably efficient intramolecular cyclization reaction. The method was further developed to provide an efficient synthesis of this type o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c171761bd59708d8b1d3945c3726f55
https://doi.org/10.1016/0960-894x(95)00350-3
https://doi.org/10.1016/0960-894x(95)00350-3
Autor:
Christopher John Rito, Steven E. Hall, Leonard L. Winneroski, Michael R. Jirousek, Douglas D. O'Bannon, Gillig James Ronald, Margaret M. Faul, John H. McDonald, David Andrew Neel, Larwence M Ballas, William Francis Heath, Anita Melikian-Badalian, Matthew Baevsky
Publikováno v:
ChemInform. 27
The synthesis of a novel class of N-N′-macrocyclic bisindolylmaleimides is reported. The key step involves a remarkably efficient intramolecular cyclization reaction. The method was further developed to provide an efficient synthesis of this type o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22427f638b95b2a02119d7b7b344efba
https://doi.org/10.1002/chin.199602196
https://doi.org/10.1002/chin.199602196
Autor:
Joseph Manetta, J. Bue, J. R. Sportsman, K. L. Sundell, Lawrence J. Slieker, William Francis Heath, H. E. Osborne
Publikováno v:
Diabetes. 41:187-193
We used antibodies to the fat/muscle glucose transporter (GLUT4) and the liver glucose transporter (GLUT2) to measure levels of these proteins in various tissues of two rodent models of non-insulin-dependent (type II) diabetes mellitus: the obese spo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a8563b54fcd27f4b0aa5d0e585d993
https://doi.org/10.2337/diab.41.2.187
https://doi.org/10.2337/diab.41.2.187
Autor:
Joseph R. Williamson, E. Di Cera, Stramm Lawrence E, Alessandro Vindigni, Richard D. DiMarchi, Yasuo Ido, William Francis Heath, Katherine Chang, Ronald E. Chance
Publikováno v:
Science (New York, N.Y.). 277(5325)
C-peptide, a cleavage product from the processing of proinsulin to insulin, has been considered to possess little if any biological activity other than its participation in insulin synthesis. Injection of human C-peptide prevented or attenuated vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a02377c81631d22738c9e0894eab050
https://pubmed.ncbi.nlm.nih.gov/9254422
https://pubmed.ncbi.nlm.nih.gov/9254422
Autor:
William Francis Heath, S. Betty Yan, J.Richard Sportsman, Albert Dee, Chris J. Vlahos, Nara Margolin, Mei-Huei T. Lai, H. Edward Osborne, Joseph Manetta
Publikováno v:
Analytical biochemistry. 202(1)
A critical step in the replicative cycle of the human immunodeficiency virus HIV-1 involves the proteolytic processing of the polyprotein products Prgag and Prgag-pol that are encoded by the gag and pol genes in the viral genome. Inhibitors of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b986eb44ef7f0494734e3c689dba3d2
https://pubmed.ncbi.nlm.nih.gov/1621970
https://pubmed.ncbi.nlm.nih.gov/1621970
Autor:
Robert F. Bruns, William Francis Heath, Isami Takahashi, F.Dean Miller, Tatsuya Tamaoki, Ronald L. Merriman, Hirofumi Nakano, J. Jeffry Howbert, Eiji Kobayashi
Publikováno v:
Biochemical and biophysical research communications. 176(1)
Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, inhibits protein kinase C by competing at the binding site for diacylglycerol and phorbol esters. Calphostin C is a polycyclic hydrocarbon with strong absorbance in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ebd8e45bc227115e4a5c701ab1d6ce
https://pubmed.ncbi.nlm.nih.gov/1708246
https://pubmed.ncbi.nlm.nih.gov/1708246
Publikováno v:
Biochemistry. 19:2454-2465
Following the development of a nondestructive synthetic procedure for rapid production of des-Val1-myoglobin in large quantities, the synthesis of a series of myoglobin derivatives varying in structure and charge in the NH2-terminal region was accomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb6811fc1f4c529bd17230e8fce57f2
https://doi.org/10.1021/bi00552a025
https://doi.org/10.1021/bi00552a025