Zobrazeno 1 - 10
of 203
pro vyhledávání: '"William F. Stenson"'
Autor:
William F. Stenson, Matthew A. Ciorba
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
TLRs, key components of the innate immune system, recognize microbial molecules. However, TLRs also recognize some nonmicrobial molecules. In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. In neo
Externí odkaz:
https://doaj.org/article/ec7806572a784628b44c15d80186f6e3
Autor:
Thomas J. Hannan, Pacita L. Roberts, Terrence E. Riehl, Sjoerd van der Post, Jana M. Binkley, Drew J. Schwartz, Hiroyuki Miyoshi, Matthias Mack, Reto A. Schwendener, Thomas M. Hooton, Thaddeus S. Stappenbeck, Gunnar C. Hansson, William F. Stenson, Marco Colonna, Ann E. Stapleton, Scott J. Hultgren
Publikováno v:
EBioMedicine, Vol 1, Iss 1, Pp 46-57 (2014)
The spread of multidrug-resistant microorganisms globally has created an urgent need for novel therapeutic strategies to combat urinary tract infections (UTIs). Immunomodulatory therapy may provide benefit, as treatment of mice with dexamethasone dur
Externí odkaz:
https://doaj.org/article/06a88a77574746e8a4a2cabcd13ca808
Autor:
Emily J. Westover, Xiaobo Lin, Terrence E. Riehl, Lina Ma, William F. Stenson, Douglas F. Covey, Richard E. Ostlund, Jr.
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 11, Pp 2374-2381 (2006)
To probe the pathway and specificity of cholesterol absorption, the synthetic enantiomer of cholesterol (ent-cholesterol) and cholesterol were labeled with deuterium, gavaged into hamsters, and measured by negative ion mass spectrometry. Initial upta
Externí odkaz:
https://doaj.org/article/2d7c2dde6b9e4a6ebf1ee8f3ee4ac326
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 8, Pp 1453-1458 (1999)
While unphysiologically large cholesterol doses are known to reduce percent cholesterol absorption, smaller amounts are reported to have no effect in human subjects. To determine the dose–response relation between dietary cholesterol consumed and t
Externí odkaz:
https://doaj.org/article/840c0293a0644115b16158137fd54c68
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 2, Pp 302-308 (1999)
Abstract Percent cholesterol absorption was measured in 94 normal subjects aged 17–80 years while consuming diets generally low in cholesterol (mean intake = 226 ± 126 mg/day). A new dual stable isotope method was used where a cholesterol tracer c
Externí odkaz:
https://doaj.org/article/b4e5e08be65a411081f7645ca0416d19
Autor:
William F. Stenson, Matthew A. Ciorba, David M. Alvarado, Yan Yan, Baosheng Chen, Terrence E. Riehl, Sarbjeet Makkar
Hyaluronic acid (HA), a constituent of the extracellular matrix, promotes colorectal cancer growth. CD44 is a relevant HA receptor in this context. However, HA is also a ligand for TLR4, a receptor of significance in colorectal cancer. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb72cfd5b62a9f6f70c40c8c5d4eb1d
https://doi.org/10.1158/1535-7163.c.6539343
https://doi.org/10.1158/1535-7163.c.6539343
Autor:
William F. Stenson, Matthew A. Ciorba, David M. Alvarado, Yan Yan, Baosheng Chen, Terrence E. Riehl, Sarbjeet Makkar
supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34f4b275b472514b355ba5c9e31ae42
https://doi.org/10.1158/1535-7163.22509600
https://doi.org/10.1158/1535-7163.22509600
Autor:
Deliang Cao, Duan-Fang Liao, William F. Stenson, Mei Chris Huang, Jianghua Liu, Xuyu Zu, Laxiang Wan, Yingchun He, Yu Cao, Yiwen Bu, Chenfei Huang, John Gao, Wancai Yang, Xiaoning Li, Hongyan Ling, Ruilan Yan, Jun Ma, Yi Shen
Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7aa35704aa330e5e813dbe5e4ddae1
https://doi.org/10.1158/1078-0432.c.6523917
https://doi.org/10.1158/1078-0432.c.6523917
Autor:
Deliang Cao, Duan-Fang Liao, William F. Stenson, Mei Chris Huang, Jianghua Liu, Xuyu Zu, Laxiang Wan, Yingchun He, Yu Cao, Yiwen Bu, Chenfei Huang, John Gao, Wancai Yang, Xiaoning Li, Hongyan Ling, Ruilan Yan, Jun Ma, Yi Shen
Supplemental Figures S1-6, Tables S1-7. Figure S1. Targeted disruption of AKR1B8 gene. Figure S2. AKR1B and AKR1C subfamily expression. Figure S3. Deficiency of proliferation and self-renewal of colonic crypt cells in AKR1B8 -/- mice. Figure S4. DSS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac58dd7208294b177c0224ed74e2203
https://doi.org/10.1158/1078-0432.22458351.v1
https://doi.org/10.1158/1078-0432.22458351.v1
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 319:G63-G73
Hyaluronic acid (HA), a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously demonstrated that both CD44 and TLR4, but predominately TLR4, mediated HA stimulation of Lgr5+ stem cell proliferation