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pro vyhledávání: '"William F. Huffaman"'
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo